Detection of Diffuse Beta-amyloid Plaques in TBI Patients Using PET Imaging

Study ID
STU 042011-055

Cancer Related

Healthy Volunteers

Study Sites

  • UT Southwestern-Other
  • Clements University Hospital
  • Zale Lipshy University Hospital
  • Parkland Health & Hospital System

Cari Stebbins

Principal Investigator
Joshua Gatson, Ph.D.


using the Positron emission Tomography we plan to measure the beta-amyloid brain levels in patients that have experienced a severe head injury. We will assess the plaque levels at the short (at hospital discharge [about 1 month post-injury]) and long-term (1, 2, and 5 years post-injury) time-points. These studies will help elucidate if patients that suffer severe head injuries and have good outcomes accumulate large amounts of amyloid plaques in the brain.

Participant Eligibility

1. Patients between the ages 18-50 years old
2. Both men and women
3. Patients that suffered a mild/moderate/severe head injury admitted to Parkland hospital with
a GCS between 3-15
4. GCS between 13 and 15 at the time of hospital discharge
5. GOS greater than or equal to 4
6. Subject or authorized representative has provided full written informed consent prior to
the performance of any protocol-specified procedure