Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Study ID
STU 042011-034

Cancer Related

Healthy Volunteers

Study Sites

  • Clements University Hospital
  • UT Southwestern Ambulatory Services
  • Zale Lipshy University Hospital

Safee Ahmed

Principal Investigator
Amit Sawant

Official Title

Investigating the Feasibility of Using Rapid Cine-MRI for Monitoring Moving and Deforming Tumors

Brief Overview

In this study, the researchers investigate the feasibility of using rapid cine MR imaging to
provide both offline and online soft-tissue-based image guidance. Such images will provide a
significantly more complete picture of the spatial and temporal changes in thoracic anatomy.
This more complete information will lay the groundwork for better radiotherapy planning and
dose delivery in the presence of respiratory motion.


Rapid MRI scans from Stage I-IV non-small-cell lung cancer (NSCLC) patients will be
acquired. MR acquisition will be performed without extrinsically administered contrast,
using a balanced turbo field echo (TFE) sequence and commercially available coils.

Participant Eligibility

Inclusion Criteria:

- AJCC Stage I, II, III or IV non-small-cell lung cancer to be treated using
radiotherapy will be eligible for this study.

- Any types and amounts of prior therapy will be allowed for this study.

- Subjects must be greater than or equal to 18 years of age. There are no gender or
ethnic restrictions.

- Ability to understand and the willingness to sign a written informed consent

- Able to tolerate supine position

- ECOG performance status of 3 or less

Exclusion Criteria:

- MRI-incompatible metallic implants, embedded metallic objects, implanted biomedical
devices e.g., cardiac pacemakers

- Women who are pregnant or trying to get pregnant

- Pain in supine position