Clinical and Immunological Studies of Vitiligo

Study ID
STU 032013-069

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

Contact
Vanessa James
214-648-7010
vanessa.james@utsouthwestern.edu

Principal Investigator
Amit Pandya

Summary

This is a case-control study of adult and pediatric vitiligo patients.
our prospective aims are to compare patients with vitiligo to each other and to normal and immune-mediated disease control patients, comparing clinical characteristics, autoimmune blood markers, autoimmune disorders, and family history of autoimmune disorders. This vitiligo cohort, including adult and pediatric patients will be followed prospectively (patients will be followed over time) and will be reevaluated longitudinally to investigate the natural history, presence of co-morbidities, and response to treatment.

Some patients will be recruited retrospectively via chart review of the Pi's own patients. our retrospective aims are to compare patients with vitiligo to each other and to prospectively obtained normal and immune-mediated disease control patients, comparing clinical characteristics, autoimmune blood markers, autoimmune disorders, and family history of autoimmune disorders. We will also be comparing results of treatment modalities in the vitiligo patients.

Participant Eligibility

Vitiligo Patient Study Group

* Diagnosed with vitiligo by clinical findings

* Patients of any age

* Male or Female

* All ethnic groups

* Patient or legal guardian must be able to speak and read English or Spanish at a 6th grade reading level (a translator will be available with additional consent forms in Spanish)

* Ability to give written informed consent

* Relationships to proband: A subject[Single Quote]s family history will be reviewed and if there is a family history of vitiligo, then we will give the study subject the investigator[Single Quote]s contact information and request the subject ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so.

Disease Control Group:

* Diagnosed with an immune-mediated skin disease (i.e. psoriasis or eczema) by clinical, laboratory, and/or histopathological findings

* Patients of any age

* Male or Female

* All ethnic groups

* Ability to speak and read English or Spanish at a 6th grade reading level (a translator will be available with additional consent forms in Spanish)

* Ability to give written informed consent

Normal Control Group:

* Negative history of autoimmune diseases

* Patients of any age

* Male or Female

* All ethnic groups

* May include first degree relatives of patients diagnosed with vitiligo

* Ability to speak and read English or Spanish at a 6th grade reading level (a translator will be available with additional consent forms in Spanish)

* Ability to give written informed consent

* Surgical procedure that resulted in creation of surgical waste by no other action than the surgery itself