Treatment for Calcium Phosphate Kidney Stone Disease

Study ID

Cancer Related

Healthy Volunteers

Study Sites

  • UT Southwestern-Clinical Translational Research Center (CTRC)
  • UT Southwestern Ambulatory Services
  • Zale Lipshy University Hospital
  • Parkland Health & Hospital System

Ashlei Johnson-Wilder

Principal Investigator
Naim Maalouf, M.D.

Official Title

Pharmacological Therapy for Calcium Phosphate Urolithiasis

Brief Overview

The investigators will examine in two studies whether citric acid or potassium citrate can
reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

Participant Eligibility

Inclusion Criteria:

Aim 1

- Hypocitraturic CaP stone formers

- urine citrate <320mg/d

- elevated pH as 24-hr urine pH above 6.40

- >21 years

Aim 2

- Hypercalciuric CaP stone formers

- 24hr urine calcium >250mg/d in women and >300mg/d in men prior to indapamide use

- high pH as >6.40 in the absence of urinary tract infection

- >21 years