Hippocampal Neurogenesis in Human Subjects (Pilot Study)

Study ID
STU 032012-021

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

  • UT Southwestern-Other
  • UT Southwestern-Clinical Translational Research Center (CTRC)

Contact
Julianne Price
214-645-6901
julianne.price@utsouthwestern.edu

Principal Investigator
Bryon Adinoff

Summary

Preliminary data will be obtained in cocaine-addicted subjects who are actively using cocaine and those who are recently abstinent (three to seven months abstinent) as well as age-, race-, and gender-similar control participants (matched to active cocaine subjects). Ten recently using and ten recently abstinent cocaine-addicted and ten age-, race-, gender similar healthy control subjects will each undergo one 3T scan at the aiRC. each scanning session will consist of Magnetic Resonance Spectroscopy and Vascular-Space-occupancy imaging scans to measure the number of nPCs in the brain. each session will last approximately two hours. Data from each session will be sent to Dr. Maletic-Savatic at Baylor College of Medicine in Houston for analysis.

Participant Eligibility

For Recent Cocaine-addicted patients:
1. any race and either gender.
2.between the ages of 18-55 years old.
3. meet DSM-IV criteria for cocaine abuse or dependence and must identify cocaine as their present primary drug of use.
4. actively using cocaine on a regular basis (within 1 week from last use to study scan).

For Recent abstinent Cocaine patients:
1. any race and either gender.
2.between the ages of 18-55 years old.
3. meet DSM-IV criteria for cocaine abuse or dependence and must identify cocaine as their present primary drug of use.
4. Abstinent from cocaine for a duration of the past 3-7 months

For controls that are age-, sex-, and gender-matched with cocaine-addicted subjects
1. any race and either gender.
2. 18-55 years old