Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma

Study ID
AOST06B1

Cancer Related
No

Healthy Volunteers
No

Study Sites

  • Children’s Medical Center (Dallas, Plano, Southlake)

Contact


Principal Investigator

Official Title

A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

Brief Overview


RATIONALE: Collecting and storing samples of tumor tissue and blood from patients to test in
the laboratory may help the study of cancer in the future.

PURPOSE: The purpose of this study is to collect and store samples of blood and tumor tissue
from patients with osteosarcoma.

Summary


OBJECTIVES:

- To collect biological specimens from patients with osteosarcoma at Children's Oncology
Group (COG) institutions.

- To provide a repository for long-term storage of osteosarcoma-related biological
materials.

- To make these specimens available to qualified researchers to understand the biology of
osteosarcoma and correlate these results with the patients' clinical data.

OUTLINE: After the initial submission of blood samples, patients may undergo open or closed
biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded
material. Patients who are enrolled at the time of initial diagnosis but then have a
definitive surgery or develop recurrent disease may submit additional samples (paraffin
block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor
samples may also be submitted.

Participant Eligibility


DISEASE CHARACTERISTICS:

- All osteosarcoma patients seen at COG institutions are eligible, including the
following:

- Newly diagnosed patients

- Patients with recurrent disease who were not enrolled at the time of diagnosis

- The following specimens from the initial biopsy (and/or definitive surgery if an
up-front resection is performed) are required:

- Paraffin embedded block OR 30 unstained slides

- Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized
whole blood

- Fresh and frozen tumor specimens

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Patients are not required to enter a therapeutic study to enroll on this study