AOST06B1, A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
To collect tissue and peripheral blood samples of patients with osteosarcoma for use to analyze biological factors and to deposit in a tissue bank. Samples will be collected at the time of initial diagnosis, at the time of surgical procedure, at relapse/progression (if applicable) and at autopsy (if applicable). These samples will be obtained when other samples are obtained for standard care. These samples can be used for approved projects by laboratory-based investigators. The number of subjects to be enrolled on this study is unlimited.
All osteosarcoma patients seen at COG institutions are eligible. This includes:
a. newly diagnosed patients
b. patients with recurrent disease who were not enrolled at the time of diagnosis
Patients must be between the ages 0 x 21 years. All patients and/or their parents or legal guardians must sign a written informed consent. All institutional, FDA, and NCI requirements for human studies must be met.