Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma

Study ID

Cancer Related

Healthy Volunteers

Study Sites

  • Children’s Medical Center (Dallas, Plano, Southlake)

Zain Rahimi

Principal Investigator
Patrick Leavey, M.D.

Official Title

A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens

Brief Overview

RATIONALE: Collecting and storing samples of tumor tissue and blood from patients to test in
the laboratory may help the study of cancer in the future.

PURPOSE: The purpose of this study is to collect and store samples of blood and tumor tissue
from patients with osteosarcoma.



- To collect biological specimens from patients with osteosarcoma at Children's Oncology
Group (COG) institutions.

- To provide a repository for long-term storage of osteosarcoma-related biological

- To make these specimens available to qualified researchers to understand the biology of
osteosarcoma and correlate these results with the patients' clinical data.

OUTLINE: After the initial submission of blood samples, patients may undergo open or closed
biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded
material. Patients who are enrolled at the time of initial diagnosis but then have a
definitive surgery or develop recurrent disease may submit additional samples (paraffin
block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor
samples may also be submitted.

Participant Eligibility


- All osteosarcoma patients seen at COG institutions are eligible, including the

- Newly diagnosed patients

- Patients with recurrent disease who were not enrolled at the time of diagnosis

- The following specimens from the initial biopsy (and/or definitive surgery if an
up-front resection is performed) are required:

- Paraffin embedded block OR 30 unstained slides

- Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized
whole blood

- Fresh and frozen tumor specimens


- Not specified


- Patients are not required to enter a therapeutic study to enroll on this study