Collecting and Storing Samples of Bone Marrow and Blood From Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma

Study ID
AALL05B1

Cancer Related
Yes

Healthy Volunteers
No

Study Sites

  • Children’s Medical Center (Dallas, Plano, Southlake)

Contact
Alison Patterson
214-456-2726
alison.patterson@childrens.com

Principal Investigator
Tamra Slone, M.D.

Official Title

A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

Brief Overview


This research study is collecting and storing samples of bone marrow and blood from patients
with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and
storing samples of bone marrow and blood from patients with cancer to study in the
laboratory may help doctors learn more about cancer and help predict the recurrence of
cancer.

Summary


OBJECTIVES:

I. Establish a mechanism to bank specimens of tumor cells and host germline DNA from
patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.

II. Make these specimens available to qualified researchers to study the biology of ALL.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse
and/or at the end of the first month of treatment.

Patients are followed periodically for up to 10 years.

Participant Eligibility


Inclusion Criteria:

- Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin
lymphoma

- In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or
peripheral blood

- Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of
diagnosis of relapse

- No concurrent systemic antileukemic treatment administered for current relapse

- Intrathecal chemotherapy allowed

- On-therapy relapse allowed