Establishing a Database on the Plasma Level of Klotho in Humans, in Health and Disease

Study ID
STU 022011-126

Cancer Related
No

Healthy Volunteers
No

Study Sites

  • Children's Medical Center-Dallas
  • Children's Medical Center-Dallas
  • Children's Medical Center-Dallas
  • Children's Medical Center-Dallas
  • Children's Medical Center-Dallas
  • Parkland Health & Hospital System
  • Parkland Health & Hospital System
  • Parkland Health & Hospital System
  • Parkland Health & Hospital System
  • Parkland Health & Hospital System
  • UT Southwestern Ambulatory Services
  • UT Southwestern Ambulatory Services
  • UT Southwestern Ambulatory Services
  • UT Southwestern Ambulatory Services
  • UT Southwestern Ambulatory Services
  • UT Southwestern University Hospital– Zale Lipshy
  • UT Southwestern University Hospital– Zale Lipshy
  • UT Southwestern University Hospital– Zale Lipshy
  • UT Southwestern University Hospital– Zale Lipshy
  • UT Southwestern University Hospital– Zale Lipshy
  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern University Hospital—St. Paul
  • UT Southwestern-Other
  • UT Southwestern-Other
  • UT Southwestern-Other
  • UT Southwestern-Other
  • UT Southwestern-Other

Contact
De'Anica Gonzalez
214-648-6790
deanica.gonzalez@utsouthwestern.edu

Principal Investigator
Orson Moe

Summary

Subjects
Inclusion:
Aim 1: One hundred eighty adult subjects, age 18 or older will be equally distributed in the following age groups (years): 21-30, 31-40, 41-50, 51-60, 61-70 and and amp;gt;71. In each age group there will be 8 female and 8 male subjects. We also wish to collect serum ceruloplasmin in a subset (20 subjects) in healthy volunteers to use as a control for the serum ceruloplasmin collected in the dialysis patients from Aim 2. The additional enrollment (64)is to compensate for those subjects that have not completed the entire study. Ten pediatric subjects between the ages of 3 and 18 years of age. Siblings of pediatric renal disease or kidney stone patients will be recruited in the Renal and Urology Clinics at Children[Right Quote]s Hospital.
Aim 2: Two hundred adult patients 18 years of age with a history of renal disease, 100 female and 100 male, will be selected through consecutive sampling from the UTSW Renal Clinic, the University Hospitals and from the Renal Clinic, the Dialysis Unit, and from inpatient renal patients at Parkland Hospital. These patients will be equally distributed according to their eGFR among the five groups of eGFR. The eGFR groups are defined as: group1: eGFR and amp;gt;91 ml/min; groups 2: eGFR 60-89 ml/min; eGFR 3: 30-59 ml/min; eGFR 4: 15-29 ml/min; eGFR 5: and amp;lt;15 ml/min. eGFR will be calculated using the following formula: eGFR = 170 x [PCr]-0.999 x [Age]-0.176 x [0.762 if pt. is female] x [1.180 if pt. is black] x [SUN]-0.170 x [Alb]+0.318 as described previously [23]. Up to 10 pediatric patients will be recruited from the Pediatric Renal and Urology Clinics at Children[Right Quote]s Hospital.
Aim 3: Fifty adult subjects greater than 18 years with a history of calcium kidney stones from the Mineral Metabolism Clinic at Aston. The patients will be equally distributed in the following age groups: 18-30, 31-40, 41-50, 5 1-60, 61-70 and and amp;gt;71. Fifty adult subjects greater than 18 years with a history of uric acid kidney stones from the Mineral Metabolism Clinic at Aston. The patients will be equally distributed in the following age groups: 18-30, 31-40, 41-50, 5 1-60, 61-70 and and amp;gt;71.

Participant Eligibility

Aim 1: One hundred eighty adult subjects, age 18 or older will be equally distributed in the following age groups (years): 21-30, 31-40, 41-50, 51-60, 61-70 and >71. In each age group there will be 8 female and 8 male subjects. We also wish to collect serum ceruloplasmin in a subset (20 subjects) in healthy volunteers to use as a control for the serum ceruloplasmin collected in the dialysis patients from Aim 2. The additional enrollment (64)is to compensate for those subjects that have not completed the entire study. Ten pediatric subjects between the ages of 3 and 18 years of age. Siblings of pediatric renal disease or kidney stone patients will be recruited in the Renal and Urology Clinics at Children[Single Quote]s Hospital.
Aim 2: Two hundred adult patients 18 years of age with a history of renal disease, 100 female and 100 male, will be selected through consecutive sampling from the UTSW Renal Clinic, the University Hospitals and from the Renal Clinic, the Dialysis Unit, and from inpatient renal patients at Parkland Hospital. These patients will be equally distributed according to their eGFR among the five groups of eGFR. The eGFR groups are defined as: group1: eGFR >91 ml/min; groups 2: eGFR 60-89 ml/min; eGFR 3: 30-59 ml/min; eGFR 4: 15-29 ml/min; eGFR 5: <15 ml/min. eGFR will be calculated using the following formula: eGFR = 170 x [PCr]-0.999 x [Age]-0.176 x [0.762 if pt. is female] x [1.180 if pt. is black] x [SUN]-0.170 x [Alb]+0.318 as described previously [23]. Up to 10 pediatric patients will be recruited from the Pediatric Renal and Urology Clinics at Children[Single Quote]s Hospital.
Aim 3: Fifty adult subjects greater than 18 years with a history of calcium kidney stones from the Mineral Metabolism Clinic at Aston. The patients will be equally distributed in the following age groups: 18-30, 31-40, 41-50, 5 1-60, 61-70 and >71. Fifty adult subjects greater than 18 years with a history of uric acid kidney stones from the Mineral Metabolism Clinic at Aston. The patients will be equally distributed in the following age groups: 18-30, 31-40, 41-50, 5 1-60, 61-70 and >71.