Neuropsychological and Behavioral Testing in Younger Patients With Cancer

Study ID

Cancer Related

Healthy Volunteers

Study Sites

  • UT Southwestern-Other
  • Children’s Medical Center (Dallas, Plano, Southlake)

Natasha Anderson

Principal Investigator
Patrick Leavey, M.D.

Official Title

Neuropsychological, Social, Emotional, and Behavioral Outcomes in Children With Cancer

Brief Overview

This research trial studies neuropsychological (learning, remembering or thinking) and
behavioral testing in younger patients with cancer. Collecting information over time from a
series of tests may help doctors develop effective tests to measure neuropsychological and
behavioral function of patients with cancer.



I. To utilize a standardized battery of age-appropriate neuropsychological and behavioral
tests in conjunction with Children's Oncology Group (COG) Phase III clinical trials to
evaluate cognitive, social, emotional, and behavioral functioning over time.

II. To institute procedures to ensure a consistent, streamlined, and efficient
administration of the neuropsychological/behavioral tests in a cooperative group setting in
order to maximize compliance with a standardized assessment battery conducted at 3
standardized timepoints.


Parent and child participants complete the COG Standard Neuropsychological and Behavioral
Battery testing at 9, 30, and 60 months post-diagnosis in a 1-hour session conducted by a
neuropsychologist or psychologist. The Battery consists of tests of intelligence, processing
speed/attention, memory, language preference, general developmental progress, attention and
behavior/social/emotional function, executive function, adoptive function, and quality of
life. Additionally, parents complete a parent-report questionnaire to gather information
about patient's function in terms of attention, memory, executive abilities, and behavioral,
social, and emotional adaption.

Participant Eligibility

Inclusion Criteria:

- The patient must be currently be enrolled or plan to be enrolled on a COG therapeutic
study that aims to examine neuropsychological, social, emotional, and/or behavioral

- The patient must have receptive and expressive English language skills

Exclusion Criteria:

- Patients with a history of severe or profound mental retardation (i.e. intelligence
quotient [IQ] =< 50) are not eligible for enrollment; PLEASE NOTE: Children with a
prior history of attention deficit hyperactivity disorder (ADHD) or a specific
learning disability (e.g. dyslexia) are eligible for this study