Comprehensive assessment of gait and balance in patients with neurologic disease.

Study ID
STU 112013-037

Cancer Related

Healthy Volunteers

Study Sites

  • UT Southwestern Ambulatory Services

Ashley Gerald

Principal Investigator
Pravin Khemani, M.D.


This is a prospective, observational study of gait in patients with neurologic disease. To recruit the initial cohort we will query uTSW clinical ePiC database to identify ambulatory patients with atypical parkinsonian conditions and early alzheimer's disease and invite them to join the study. We expect to contact approximately 40 patients with each disease (80 total) to identify 40 who agree to come in for the initial gait evaluation. We plan to conduct subsequent gait evaluations every 12 months during regular clinical appointments to minimally inconvenience the patients and maintain high retention rate. The gait lab is conveniently located in the clinical area. We will enroll additional patients from the clinic as they present for routine appointments. There are about 100 atypical parkinsonian patients seen every year in uTSW aston Movement Disorders clinic (including established patients). Since many patients are non-ambulatory, some may not wish to participate, we estimate additional 10 patients will be enrolled per year. We will utilize existing database (PD Biomarker study) to obtain gait parameters for patients with PD and healthy controls. We may enroll additional PD and control patients (typically patients' spouses) to achieve appropriate age- and severity-matched comparison with atypical parkinsonism and early alzheimer's disease patients. additional patients will be recruited during regular clinic visits.

Participant Eligibility

a. Diagnosis of atypical parkinsonian condition established in the UTSW Clinical Center for Movement Disorders
b. Diagnosis of idiopathic Parkinson[Single Quote]s disease established in the UTSW Clinical Center for Movement Disorders
c. Diagnosis of Alzheimer[Single Quote]s disease or mild cognitive impairment established in the UTSW Clinical Center for Memory Disorders
d. Diagnosis of any neurologic condition suspected to cause gait impairment established in the UTSW Clinical Center for Movement Disorders
e. Healthy controls
f. Ability to walk at least 10 feet independently (without using a walking device)
g. Ability to comply with simple commands during testing (stand, walk, sit, etc).