Contributions of the Gut Microbiome to Anxiety Symptomatology

Study ID
STU 092015-039

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

  • UT Southwestern-Other

Contact
Brittany Mason
214/645-6957
BRITTANY.MASON@UTSouthwestern.edu

Principal Investigator
Brittany Mason, Ph.D.

Summary

Better physiological characterization of mood disorders will help in the diagnosis and treatment of these disorders. By analyzing the composition of the gut microbiome and relating it to the presentation of mood disorders, we may add a significant biological component to assist in designing personalized treatments. This pilot study will be conducted at uTSW as collaboration between Psychiatry and Microbiology and seeks to contribute novel markers for the characterization of mood disorders.

The primary aim for this project is to correlate the distribution of gut microbiota to anxiety symptoms in patients with mood disorders. The secondary aim is to correlate peripheral immune markers to the gut microbiome to determine if gut dysbiosis may play a role in modulating dysfunction in this system. any potential relationships determined by these analyses will be further examined with genetic information (such as Dna or Rna).

Participant Eligibility


* Adults, age 18-64

* Written informed consent obtained

* Outpatients with a current primary diagnosis of nonpsychotic MDD, GAD or Anxiety NOS per the SCID-IV or those that are psychologically healthy controls

* Having a QIDS-SR score of >=9 or GAD-7 of > 8 (unless healthy control)

* Agrees to all biological collection procedures (stool sample and blood draw)