Biological Substrates of Impaired Neurocognitive Functioning: Understanding the Late Effects of Surviving a Pediatric Brain Tumor

Study ID
STU 072015-083

Cancer Related
Yes

Healthy Volunteers
Yes

Study Sites

  • Children’s Medical Center (Dallas, Plano, Southlake)

Contact
Rayna Ross-Smith
214/456-2826
RAYNA.ROSS@childrens.com

Principal Investigator
Nancy Rollins, M.D.

Summary

Survivors of pediatric brain tumors commonly struggle with progressive declines in attention
and memory that emerge following neurosurgery, chemotherapy and radiation.
unfortunately, little is known about the neurobiological substrates of these cognitive
dysfunctions. Consequently, the aim of this study is to identify the specific changes in
functional and structural brain connectivity that correlate with neurocognitive decline by
collecting advanced magnetic resonance imaging (MRi) and neuropsychological test data on
Survivors of pediatric benign and malignant posterior fossa brain tumors and comparing them
with healthy controls across 3 academic medical centers: Columbia university Medical
Center, Children's Medical Center-Dallas and Seattle Children's Hospital.

Participant Eligibility

Inclusion Criteria for Children Treated for Posterior Fossa Tumors:
1. Successfully completed all medical treatment for either an M0 posterior fossa medulloblastoma without dissemination or posterior fossa low-grade astrocytoma without relapse or evidence of residual disease.
2. Medulloblastoma survivors should have been previously treated with gross total resection, craniospinal irradiation with conformal posterior fossa boost radiotherapy and chemotherapy; whereas, low grade astrocytoma survivors should have been treated with gross total resection only and no chemotherapy or radiotherapy.
3. Subjects are between 1-4 years post completion of their medical treatment for their posterior fossa brain tumor and between the ages of 6 through 16 years at time of consent.
Inclusion Criteria for Healthy Control Participants:
1. No major medical illness, as determined by medical interview by study physician.
2. Subject is currently between the ages of 6-16 years of age.