Validation of a Short Memory Tool (ECA) Designed Specifically for use During and After Electroconvulsive Therapy (ECT)

Study ID
STU 072015-040

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

  • UT Southwestern-Other
  • Zale Lipshy University Hospital

Contact
Aatika Parwaiz
214/648-2806
Aatika.Parwaiz@UTSouthwestern.edu

Principal Investigator
Mustafa Husain, M.D.

Summary

Protocol was developed by the leading center at emory university. There are differences between emory university's protocol and the one to be conducted at the uT Southwestern. The differences are in: 1, the number of enrolled participants; 2, groups of participants to be enrolled; emory site is amending the protocol and adding a Quick inventory of Depressive Symptomatology -self report (QiDS-SR). QiDS is designed to access severity of depression. uTSW site will be giving participants QiDS-SR to complete.
uTSW will enroll 50 depressed individuals with Major Depressive Disorder or Bipolar Disorder who will be receiving electroconvulsive (eCT) treatment; in addition 25 healthy volunteers will be enrolled.
Montreal Cognitive assessment (MoCa) will be administered as a memory test per standard of care. in addition to MoCa, the electroconvulsive Cognitive assessment (eCa) will be administered. Participant's severity of depression will be assessed by self administration of the Quick inventory of Depressive Symptomatology (QiDS-SR). Three instruments (MoCa, eCa and QiDS) will be administered at three points in the study: baseline-pre eCT treatment, before 6th eCT treatment and one week after the last eCT treatment. Healthy volunteers will be evaluated at the same time intervals with the same tests.
eCa is a short memory test intended to evaluate cognitive side effects during and after the use of eCT. it is a quick and simple test targeted to the specific memory domains compromised in eCT. it covers important cognitive domains compromised in eCT; it can be administered in less than10 minutes, and fits on one page. it is a brief tool feasible to be used in a clinical setting, where assessment time is often limited.


Participant Eligibility

1. Men and women age 18 and older
2.Be willing and able to provide informed consent
3.Diagnosed with major depressive disorder or bipolar disorder and referred to receive electroconvulsive therapy
4. Healthy volunteers for healthy control group