Association between Brain Blood Flow Regulation, Cognition and Balance in Concussion

Study ID
STU 062016-098

Cancer Related

Healthy Volunteers

Study Sites

  • UT Southwestern-Other

Candice Osborne

Principal Investigator
Kathleen Bell


a prospective case-control design will include 50 student athletes, both men and women, between 18-27 years following a sport-related concussion. Fifty gender and sport-matched healthy controls will also be included. Healthy controls will be assessed only once. athletes with concussion will undergo assessment three times, each measure will be repeated on day-3, day-21 and month-3 following concussion. each visit will be approximately three hours long. all recruitment and procedures will take place on the SMu campus in Dallas. Data analysis will take place on SMu and uTSW campuses.

Test instruments: Cognition will be assessed using Sport Concussion assessment Tool 3rd version (SCaT3), Trail Making Test a and B, and n-Back tests. Subjects will complete questionnaires regarding neurological symptoms, health history, sports injury, sleep and depression. neurological assessments will include the King Devick test, an eye-tracking test (oculogica), and postural sway using a force plate. Blood biomarkers of neuronal damage will be assessed. no genome testing will occur. CBF regulation will be examined from continuous measurements of heart rate (3-lead electrocardiogram), arterial blood pressure (finger photoplethsmography), cerebral blood flow velocity (transcranial Doppler ultrasonography) and end-tidal carbon dioxide (capnography) during various physiologic maneuvers.

Participant Eligibility

-Student athlete at SMU
-Actively participating in any NCAA sports or recreational sports
-Willing to provide informed consent for participation in the study