Exercise in Burn Survivors

Study ID
STU 042014-060

Cancer Related
No

Healthy Volunteers
Yes

Study Sites

  • Advanced Imaging Research Center (AIRC)
  • CTRC Outpatient
  • Clements University Hospital
  • IEEM at Presbyterian Hospital of Dallas
  • UT Southwestern-Other

Contact
Amy Adams
214/345-4619
AmyAdams3@texashealth.org

Principal Investigator
Craig Crandall, Ph.D.

Summary

Both uninjured control and well-healed burned subjects will be recruited to participate in a 6 month exercise training protocol. The effects of this exercise training regimen will be evaluated by comparing pre/post exercise training response for the variables indicated in Table 1 (the number of days will vary depending on scheduling and availability; see page 2 of the protocol for Table 1).

Primary outcome Variables
The primary outcome variables are maximal aerobic capacity, muscle histology and biochemistry, and cardiovascular responses to steady state exercise.

Study endpoints
Data collection will end when 12 subjects per group (i.e., non-burned control, 20-35% BSa burned, 36-55% BSa burned, and [Greater Than]55% BSa burned) have completed the protocol.

Participant Eligibility

Inclusion Criteria for uninjured control subjects:

* 18-60 years of age

* Healthy, although subjects with controlled hypertension or hypercholesterolemia will be permitted to participate

* Male and female


Inclusion Criteria for burned subjects:

* 18-60 years of age

* Healthy, although subjects with controlled hypertension or controlled hypercholesterolemia will be permitted to participate

* Male and female

* Experienced a burn injury covering at least 20% of their BSA

* Hospitalization of at least 15 days due to their burn injuries

* Well healed burn injuries