Comparative Analysis of Chronobiological Changes in Burn, Trauma and Traumatic Brain Injury

Study ID
STU 012014-061

Cancer Related
No

Healthy Volunteers
No

Study Sites

  • Parkland Health & Hospital System

Contact
Peter Gales
214/648-7609
Peter.Gales@UTSouthwestern.edu

Principal Investigator
Steven Wolf, M.D.

Summary

in this study we will measure circadian biomarkers in the blood and urine of trauma, TBi and burn injured patients admitted to the intensive care unit. We propose to collect blood and urine samples every 6 hours for 24 hours within the first 24-48 hours after injury. We will then collect samples every 12 hours for 2 days, followed by daily collections for 4 days. Patients will be treated according to the standard of care in the iCu for light dark cycle. We will measure patient sleep wake cycles and ambient light levels with actigraphy. We will correlate the biomarker findings with clinically measured biometrics such as vital signs, other lab data as well as the patient outcomes documented in the electronic medical record.

Participant Eligibility

1. Study participants between the ages of 18-50. (Burn patients: n=10, Trauma patients: n=10, TBI patients: n=10, Control subjects: n=10)
2. Men only
3. Intensive care patient with estimated >20% TBSA burn, or CT documented TBI including intracranial haemorrhage, or traumatic injuries with no head injury admitted within 24 hours will be screened for participation
4. Subject (or LAR) has provided full written informed consent prior to the performance of any protocol-specified procedure