Current Extramural Funding

Noninvasive Assessment of Pancreatic Beta-Cell Mass

Grant Period: 09/01/2011–08/30/2016
Principal InvestigatorsXiankai Sun, Ph.D.Orhan K Öz, M.D., Ph.D.
Funding Agency: National Institutes of Health
Grant Number: NIH 1 R01 DK092163-01
Project Goal: To develop a practical PET-CT imaging approach with clinically acceptable accuracy and reproducibility for noninvasive assessment of pancreatic beta-cell mass.

Acquisition of Biomedical Cyclotron and Development of Comprehensive Positron Emission Tomography Program at UT Southwestern for Cancer Research

Grant Period: 08/01/2011–07/31/2016
Principal InvestigatorXiankai Sun, Ph.D.
Funding Agency: Cancer Prevention Research Institute of Texas
Grant Number: RP110771
Project Goal: To acquire a biomedical cyclotron and develop a comprehensive PET program for cancer research projects at UT Southwestern.

Targeting Aggressive Prostate Cancer with Novel Theranostic Nanomedicine

Grant Period: 09/30/2011–08/29/2016
Co-InvestigatorJ.T. Hsieh, Ph.D.
Funding Agency: National Institutes of Health
Grant Number: NIH R01CA159144-01
Project Goal: To construct dendrimer-based nanoconjugates presenting three functional molecules for prostate cancer treatment.

Targeting Tumor Microenvironment for Cancer Imaging and Therapy: Renal Clearable and pH Responsive Gold Nanoparticles

Grant Period: 12/01/2011 –11/30/2014
Co-Principal Investigators: Jie Zheng, Ph.D.Xiankai Sun, Ph.D.
Funding Agency: Cancer Prevention Research Institute of Texas
Grant Number: RP120588
Project Goal: To design and synthesize a gold nanoparticle-based system for cancer detection and treatment by targeting the tumor microenvironment.

Engineering Anti-Phosphatidylserine Antibodies for Cancer Therapy

Grant Period: 07/01/2011–06/30/2016
Co-Investigator: E. Sally Ward, Ph.D.
Funding Agency: Cancer Prevention Research Institute of Texas
Grant Number: RP110549
Project Goal: To develop a novel immunotherapy for cancer.

Noninvasive PET Assessment of Pancreatic Beta-Cell Mass and Function 

Grant Period: 05/01/2012–04/30/2015
Principal InvestigatorXiankai Sun, Ph.D.
Funding Agency: Juvenile Diabetes Research Foundation International
Grant Number: 37-2011-632
Project Goal: To develop a noninvasive imaging technique for the assessment of beta-cell function (BCF) in the context of gradual loss of beta-cell mass (BCM) during the type I diabetes progression.

Multi-Layered Valency: Novel Design of Peptidic Imaging Agents for avb6

Grant Period: 09/01/2012–08/31/2017
Principal Investigators: Kathlynn Brown, Ph.D., Xiankai Sun, Ph.D.
Funding Agency: National Institutes of Health
Grant Number: NIH R01 EB014244-01A1
Project Goal: To construct multi-valent PET imaging probes that target integrin avb6 for non-small cell lung carcinoma

Molecular Innovations toward Theranostics of Aggressive Prostate Cancer

Grant Period: 09/01/2012–08/31/2015
Principal InvestigatorXiankai Sun, Ph.D. (Partner PIs: J.T. Hsieh, Ph.D./Eric Simanek, Ph.D.)
Funding Agency: Department of Defense (PCRP Synergistic Idea Award)
Grant Number: DOD-PC111721
Project Goal: To construct biocompatible theranostic agents containing specific targeting molecules, therapeutic agents, and an imaging moiety for detection and therapy of advanced prostate cancer.