Mouse Metabolic Phenotyping Core

The Mouse Metabolic Phenotyping Core (MMPC) provides state-of-the-art analytical and phenotypical measures to the scientific community both inside and outside UT Southwestern Medical Center.

Our goal is to expand the scope of techniques available to investigators, standardize key methodologies, and expedite the completion of research on metabolic disorders-related diseases (diabetes and obesity), cancer, aging neurological disorders, etc.

Services

  • Chemistry analysis using VITROS MicroSlide™ technology, ELISAs, and magnetic bead mapping multiplex technology
  • Tissue extraction of cholesterol and triglyceride level
  • Metabolic chambers that measure calorimetry, activity, and food/water consumption
  • Urine collection chamber
  • Body composition analysis (DEXA, MRI, or micro-CT)
  • Glucose-insulin clamp studies
  • Seahorse XF-24(3) Extracellular Flux Analyzer for cellular metabolism study
  • Primary hepatocyte and β-cell isolation from mice or rats
  • Sphingolipid profiling using LC-MS/MS technology
  • Treadmill for mice and rats