Jaime Brugarolas, MD

Assistant Professor

Recent Publications Brugarolas, J , "Renal-Cell Carcinoma - Molecular Pathways and Therapies " NEJM , 356: 185-187 , January 2007

Brugarolas, J., K. Lei, R.L. Hurley, B.D. Manning, J.H. Reiling, E. Hafen, L.A. Witters, L.W. Ellisen, and W.G. Kaelin, Jr. , "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex " Genes Dev , 18: 2893-904 , 2004

Brugarolas, J. and W.G. Kaelin, Jr. , "Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes " Cancer Cell , 6: 7-10 , 2004

Majumder, P.K., P.G. Febbo, R. Bikoff, R. Berger, Q. Xue, L.M. McMahon,J. Manola, J. Brugarolas, T.J. McDonnell, T.R. Golub, M. Loda, H.A. Lane, and W.R. Sellers , "mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways " Nat Med , 10: 594-601 , 2004

Brugarolas, J.B., F. Vazquez, A. Reddy, W.R. Sellers, and W.G. Kaelin, Jr. , "TSC2 regulates VEGF through mTOR-dependent and -independent pathways " Cancer Cell , 4: 147-58 , 2003

Significant Publications
Brugarolas, J., B.F. Haynes, and J.R. Nevins , "Towards a genomic-based diagnosis " Lancet , 357: 249-50 , 2001

Brugarolas, J., K. Moberg, S.D. Boyd, Y. Taya, T. Jacks, and J.A. Lees , "Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation " Proc Natl Acad Sci U S A , 96: 1002-7 , 1999

Brugarolas, J., R.T. Bronson, and T. Jacks , "p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells " J Cell Biol , 141: 503-14 , 1998

Brugarolas, J. and T. Jacks , "Double indemnity: p53, BRCA and cancer " Nat Med , 3: 721-2 , 1997

Brugarolas, J., C. Chandrasekaran, J.I. Gordon, D. Beach, T. Jacks, and G.J. Hannon , "Radiation-induced cell cycle arrest compromised by p21 deficiency " Nature , 377: 552-7 , 1995