Jeffrey Zigman, MD
Assistant Professor
Recent Publications
M. Lutter, I. Sakata, S. Osborne-Lawrence, S.A. Rovinsky, J.G. Anderson, S. Jung, S. Birnbaum, M. Yanagisawa, J.K. Elmquist, E.J. Nestler, J.M. Zigman ,
"The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress "
Nature Neuroscience ,
11:
752-753 ,
June 2008
Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM ,
"Characterization of a novel ghrelin cell reporter mouse "
Reg Peptides ,
55:
91-98 ,
2009
Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK ,
"Mice lacking ghrelin receptors resist the development of diet-induced obesity "
J Clin Invest ,
115:
3564-3572 ,
2005
Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK ,
"Expression of Ghrelin Receptor mRNA in the Rat and the Mouse Brain "
J Comp Neurol ,
494:
528-548 ,
2006
Zigman JM, Elmquist JK ,
"Minireview: From anorexia to obesity -- the yin and yang of body weight control "
Endocrinology ,
144:
3749-3756 ,
2003
Significant Publications
Sakata I*, Yang J*, Lee CE, Osborne-Lawrence S, Rovinsky SA, Elmquist JK, Zigman JM ,
"Co-localization of ghrelin O-acyltransferase (GOAT) and ghrelin in gastric mucosal cells "
AJP Endo Metab ,
297:
E134-E141 ,
2009
R. Nogueiras, M.H. Tschoep, J.M. Zigman ,
"Central nervous system regulation of energy metabolism: ghrelin versus leptin "
Ann NY Acad Sci ,
1126:
14-19 ,
2008
Zigman JM, Elmquist JK ,
"In search of an effective obesity treatment: A shot in the dark or a shot in the arm? "
PNAS ,
103:
12961-12962 ,
August 2006
Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua Jr. S, Elmquist JK, Lowell BB ,
"Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis "
Neuron ,
49:
191-203 ,
2006
Clegg DJ, Brown LM, Zigman JM, Kemp CJ, Strader AD, Benoit SC, Woods SC, Mangiaracina M, Geary N ,
"Estradiol-dependent decrease in the orexigenic potency of ghrelin in food intake "
Diabetes ,
56:
1051-1058 ,
2007
