James Amatruda, MD
Assistant Professor
Recent Publications
Shepard JL, Amatruda JF, Finkelstein D, Ziai J, Finley KR, Stern HM, Chiang K, Hersey C, Barut B, Freeman JL, Lee C, Glickman JN, Kutok JL, Aster JC, Zon LI. ,
"A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. "
Genes & Development ,
21(1):
55-59 ,
January 2007
Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub C, Pfaff KL, Tallarico JA, King RW and Zon LI ,
"Persynthamide suppresses bmyb-associated cell cycle defects via the intra-S checkpoint. "
Nature Chemical Biology ,
1(7):
366-70 ,
December 2005
Shepard JL*, Amatruda JF*, Stern HM, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Freedman M, Lee C, Spitsbergen J, Neuberg D, Glickman JN, Kutok JL, Aster J and Zon LI (*equal contribution) ,
"A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. "
Proc Natl Acad Sci ,
102(37):
13194-9 ,
September 2005
Patton EE, Widlund H, Kutok J, Kopani K, Amatruda JF, Murphey RD, Berghamans S, Mayhall E, Traver D, Fletcher CDM, Aster J, Granter S, Look AT, Lee C, Fisher DE, Zon LI ,
"BRAF mutations are sufficient to promote nevi formation, and cooperate with p53 in the genesis of melanoma "
Current Biology ,
15:
249-254 ,
February 2005
Amatruda, JF, Shepard JL, Stern HM, Zon, LI ,
"Zebrafish as a Cancer Model System "
Cancer Cell ,
1:
216-218 ,
2002
Significant Publications
Shepard JL*, Amatruda JF*, Stern HM, Finkelstein D, Ziai J, Finley KR, Pfaff KL, Hersey C, Zhou Y, Freedman M, Lee C, Spitsbergen J, Neuberg D, Glickman JN, Kutok JL, Aster J and Zon LI (*equal contribution) ,
"A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility "
Proc Natl Acad Sci ,
in press:
,
September 2005
Patton EE, Widlund H, Kutok J, Kopani K, Amatruda JF, Murphey RD, Berghamans S, Mayhall E, Traver D, Fletcher CDM, Aster J, Granter S, Look AT, Lee C, Fisher DE, Zon LI ,
"BRAF mutations are sufficient to promote nevi formation, and cooperate with p53 in the genesis of melanoma "
Current Biology ,
15:
249-254 ,
February 2005
Amatruda JF, Cooper JA ,
"Effect of Null Mutations and Overexpression of Capping Protein on Morphogenesis, Actin Distribution and Polarized Secretion in Yeast "
J Cell Biol ,
119:
11151-1162 ,
1992
Amatruda, JF, Cannon JF, Tatchell K, Hug C, Cooper JA ,
"Disruption of the actin cytoskeleton in yeast capping protein mutants "
Nature ,
344:
352-354 ,
1990
