James Willson, MD

Professor

Recent Publications Bardelli A, Parsons DW, Silliman N, Ptak J, Szabo S, Saha S, Markowitz S, Willson JK, Parmigiani G, Kinzler KW, Wogelstein B, Velculescu VE , "Mutational analysis of the tyrosine kinome in colorectal cancers " Science , 300/5621: 949 , May 2003

Black JD, Brattain MG, Krishnamurthi SA, Dawson DM, Willson JKV , "ErbB family targeting. " Curr Opin Investig Drugs , 4(12): 1451-4 , December 2003

Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE , "High frequency of mutations of the PIK3CA gene in human cancers. " Science , 304/5670: 554 , April 2004

Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Wogelstein B, Velculescu VE , "Mutational analysis of the tyrosine phosphatome in colorectal cancers. " Science , 304/5674: 1164-6 , May 2004

Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Lui G, Hensold J, Tai HH, Wilson K, Markowitz SD , "15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-Β-induced suppressor of human gastrointestinal cancers. " Proc Natl Acad Sci USA , 101/50: 17468-73 , December 2004

Significant Publications
Markowitz S, Wang J, Myeroff l, Parons R, Sun LZ, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson JKV , "Inactivation of the type II TGF-Β receptor in RER colon cancers with microsatellite instability. " Science , 268: 1336-8 , Spring 1995

Spiro TP, Gerson SL, Liu L, Majka S, Haaga J, Hoppel CL, Ingalls ST, Willson JKV , "O6-Benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. " Cancer Research , 59: 2402-10 , May 1999

Ye SC, Foster JM, Li WH, Liang JR, Zborowska E, Venkateswarlu S, Gong JG, Brattain MG, Willson JKV , "Contextual effects of TGF-Β on the tumorigenicity of human colon carcinoma cells. " Cancer Research , 59: 4725-31 , September 1999

Dowlati A, Haaga J, Remick SC, Spiro TP, Gerson SL, Liu L, Berger SJ, Berger NA, Willson JKV , "Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. " Clinical Cancer Research , 7: 2971-6 , October 2001

Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE , "High frequency of mutations of the PIK3CA gene in human cancers. " Science , 304/5670: 554 , April 2004