Dwain Thiele, MD

Professor

Recent Publications Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB and Thiele DL , "Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo " Proc Natl Acad Sci U S A , 100: 6221-6226 , 2003

Barrie MB, HW Stout, MS Abougergi, BC Miller and DL Thiele , "Anti-viral cytokines induce hepatic expression of the granzyme B inhibitors proteinase inhibitor 9 and serine proteinase inhibitor 6 " J Immunol , 172: 6453-6459 , 2004

Abougergi MC, SJ Gidner, DK Spady, BC Miller and DL Thiele , "Fas and TNFR1 but not cytolytic granule dependent mechanisms mediate clearance of liver adenovirus infection " Hepatology , 41: 97-102 , 2004

Stout-Delgado HW, Y Getachew, TE Rogers, BC Miller and DL Thiele , "The role of serpinB9 / serine protease inhibitor 6 in preventing granzyme B dependent hepatotoxicity " Hepatology , 45: In Press , 2007

74. Stout-Delgado HW, Y Getachew, BC Miller and DL Thiele , "Intrahepatic Lymphocyte Expression of Dipeptidyl Peptidase I Processed Granzyme B and Perforin Induces Hepatocyte Expression of Serine Proteinase Inhibitor 6 (Serpinb9/SPI-6). " J. Immunol. , 179: 6561-6567 , 2007

Significant Publications
Thiele DL, Eigenbrodt ML, Bryde SE, Eigenbrodt EH and Lipsky PE , "Intestinal graft versus-host disease is initiated by donor T cells distinct from classic cytotoxic T lymphocytes " J. Clin. Invest. , 84: 1947-1956 , 1989

Thiele DL and Lipsky PE , "The action of leucyl-leucine methyl ester on cytotoxic lymphocytes requires uptake by a novel dipeptide-specific facilitated transport system and dipeptidyl peptidase I mediated conversion to membranolytic products " J. Exp. Med. , 172: 183-194 , 1990

Thiele DL and Lipsky PE , "Regulation of cellular function by products of lysosomal enzyme activity: Elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes " Proc. Natl. Acad. Sci. USA , 82: 2468-2472 , 1985

McGuire MJ, Lipsky PE and Thiele DL , "Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I " J. Biol. Chem. , 268: 2458-2467 , 1993

Thiele DL, McGuire MJ and Lipsky PE , "A selective inhibitor of dipeptidyl peptidase I impairs generation of CD8(+) T cell cytotoxic effector function " J. Immunol. , 158: 5200-5210 , 1997