Awards for July 2012

Federal Awards

Adinoff, Bryon, NIH, Striatal Dopamine Release in Response to Ultraviolet Light in Compulsive Tanners, $214,594; Alto, Neal, NIH, Type III Effector Regulation of Host GTPase Signaling, $380,842; Amatruda, James, NIH, Generation and Rapid Mapping of Low-Penetrance Disease Alleles in Zebrafish, $316,002; Beutler, Bruce, NIH, Genetic Analysis of Resistance to Viral Infection, $2,725,363; Brekken, Rolf, NIH, GPCR Regulation of Progenitor Cells in Pancreatic Cancer, $207,495; Brown, Kathlynn, NIH, Multilayered Valency: Novel Design of Peptidic Imaging Agents for alpha v beta6, $357,657; Brown, Kathlynn, NIH, Suite of Tumor Targeting Peptides for Personalized Therapy of Lung Cancer, $313,615; Brugarolas, James, NIH, Regulation of mTOR Pathway by Hypoxia and REDDI Protein, $316,002; Buszczak, Michael, NIH, Decoding Stem Cell Chromatin Using Drosophila, $292,364; Byerly, Matthew, Duke Univ./NIH, Comparison of Long-Acting Injectable Medications for Schizophrenia; ACLAIMS, $87,252.

Chalak, Lina, NIH, Cerebrovascular Dysfunction in Newborns with HIE During Hypothermia and Rewarming, $121,749; Cullum, Munro, UT Dallas/U.S. Dept. of Defense, Novel Treatment of Emotional Dysfunction in PTSD-Cullum, $99,207; Elias, Carol, NIH, Role of Leptin-Mediated P13 Kinase Signaling on Reproductive Control, $308,437; Elmquist, Joel, NIH, Interactions of Leptin and Central Serotonin Systems, $367,646; Falck, Russell, NIH, Novel Eicosanoids: Synthesis and Function, $403,524; Fitzgerald, John, Duke Univ./NIH, IPF-PANTHER: Idiopathic Pulmonary Fibrosis Clinical Research Network, $1,242; Gao, Jinming, NIH, Ultra-Responsive “On/off” Fluorescent Nanoprobes for Cancer Molecular Imaging, $366,725; Garg, Abhimanyu, U.S. FDA, Phase 2 Study of Orlistat and SLX-4090 for Type I Hyperlipoproteinemia, $397,162; Gill, Michelle, NIH, Effect of Atopy on Dendritic Cell Antiviral Responses, $397,124; Habib, Amyn, NIH, Role for RIP1 in Gliomagenesis, $307,720.

Hiesinger, Robin, NIH, Regulation of Synaptic Specificity in Visual System by Intracellular Trafficking, $373,032; Hobbs, Helen, NIH, Role of PNPLA3 in Fatty Liver Disease, $365,604; Hsieh, Jenny, NIH, Epigenetic Regulation of Adult Neurogenesis, $306,269; Hsieh, Jer-Tsong, NIH, Targeting Aggressive Prostate Cancer with Novel Theranostic Nanomedicine, $323,622; Hsieh, Jer-Tsong, U.S. Dept. of Defense, Molecular Innovations Toward Theranostics of Aggressive Prostate Cancer (Partnering with UT Southwestern X. Sun), $119,250; Igarashi, Peter, NIH, UT Southwestern O’Brien Kidney Research Core Center, $1,165,200; Igarashi, Peter, NIH, Regulation of Kidney-Specific Gene Expression, $345,825; Jacobe, Heidi, NIH, Assessment in Morphea for Establishment of Non-Cutaneous Disease (AMEND), $115,510; Jiang, Jin, NIH, Complex Regulation of Ci-Gli Proteins in Hedgehog Signal Transduction, $341,730; Jiang, Qiu-Xing, NIH, Obtaining 3-D Structures with Subnanogram Macromolecules, $253,896.

Kohler, Jennifer (N. Pham, Fellow), NIH, Sialic Acid Has Putative Signaling Roles in Muscle Disorders of Aging, $29,638; Konopka, Genevieve, NIH, FOXP2-Regulated Signaling Pathways Critical for Higher Cognitive Functions - Diversity Supplement, $66,686; Kraus, William, NIH, Activity of Nuclear Receptor Coregulators with Chromatin - Diversity Supplement, $59,173; Lee, William, U.S. FDA, Access to Serious Hepatotoxicity Surveillance Database, $134,692; Levine, Benjamin, Natl. Space Biomedical Research Inst., Team Leader for Cardiovascular Alterations Team, $60,000; Levine, Beth, NIH, Beclin 1-Bcl-2 Interactions: Effects on Autophagy, $308,934; Li, Bing, NIH, Mechanism for Chromatin Modification During Transcription Elongation, $299,001; Lin, Rueyling, NIH, CCCH Zinc-Finger Proteins and Transcriptional Repression in Germline Blastomeres in C. Elegans, $307,751; Liu, Zhi-Ping, NIH, Epigenetic Regulation of Cardiac Hypertrophy and Heart Failure, $397,291.

Lu, Hanzhang, NIH, Modulation of Brain Activity by Control of Inspired Air, $375,972; Lu, Hanzhang, Baylor Coll. of Medicine/NIH, Neurobehavioral Outcome of Head Injury in Children, $31,296; Lu, Hanzhang, UT Dallas/NIH, Neuroimaging of Dedifferentiation and Memory Across Lifespan, $19,356; Luo, Xuelian, NIH, Structure and Function of Spindle Checkpoint Proteins, $269,283; Malloy, Craig, NIH, Southwestern NMR Center for in Vivo Metabolism, $1,111,364; Marciano, Denise, NIH, Role of p120 Catenin in Metanephric Kidney Development, $148,500; Mendell, Joshua, NIH, c-Myc-Regulated microRNAs in Normal and Pathologic Cellular Physiology, $6,288; Miller, David, Gynecologic Oncology Group/NIH, Gynecologic Oncology Group Studies, $25,010; Morrison, Sean, NIH, Genetic Analysis of Stem Cell Maintenance in Vivo, $389,000; Nedzi, Lucien, American Coll. of Radiology/NIH, Radiation Therapy Oncology Group (RTOG); Agmt. #5915, $9,850.

Nesbitt, Shawna, Minneapolis Med. Research Fndtn./NIH, ASPirin in Reducing Events in Elderly, $10,980; Orth, Kim, NIH, Analysis of Newly Identified Adhesin Used by Pathogenic Gram-Negative Bacteria, $198,698; Otwinowski, Zbyszek, Argonne Natl. Lab/U.S. Dept. of Defense, Midwest Center for Structural Genomics Protein Structure Initiative: Biology, $129,850; Pandita, Tej, NIH, Chromatin Modifying Factor Control Radiation Response and Genomic Stability, $320,027; Pandita, Tej, NIH, Tumor-Cell-Specific Targets for Combined Hyperthermia and Radiation Effects, $319,944; Pedrosa, Ivan, NIH, Noninvasive Physiologic Predictors of Aggressiveness in Renal Cell Carcinoma, $297,635; Phillips, Margaret, NIH, Polyamine and Trypanothione Metabolism in Trypanosoma Brucei, $383,279; Powell, Craig, NIH, Striatal Synaptic Abnormalities in Models of Autism, $397,396; Powell, Craig, NIH, Novel Genetic Models of Autism, $337,875.

Raskin, Philip, Case Western Reserve Univ./NIH, Epidemiology of Diabetes Interventions and Complications (EDIC), $41,733; Roth, Michael, NIH, Novel Inhibitors of Viral Replication (MPI), $401,105; Roth, Michael, NIH, Using Chemical Biology to Interfere with Influenza Virus Life Cycle, $401,105; Rothermel, Beverly (D. Rotter, Fellow), NIH, Calcineurin's Role in Circadian Regulation of Cardiac Function and Remodeling, $388,575; Sadek, Hesham, NIH, Role of Meis1 in Regulation of Cardiomyocyte Proliferation, $397,291; Saha, Debabrata, U.S. Dept. of Defense, Enhancement of Radiation Therapy in Prostate Cancer by DNA-PKcs Inhibitor, $237,626; Sakhaee, Khashayar, Office of Naval Reserves, Pathophysiologic Mechanism of Ammonium Urate Nephrolithiasis in Navy Dolphins, $318,559; Scherer, Philipp, NIH, Novel Mechanisms Regulating Adipocyte-Brain-Hepatocyte Axis, $1,510,882; Scherer, Philipp, NIH, Endocrine and Metabolism Training Grant, $172,513.

Schiller, Joan, Eastern Coop Oncology Group/NIH, ECOG Clinical Trials – Federal Payments, $70,400; Schmid, Sandra, NIH, Mechanisms Regulating Clathrin-Mediated Endocytosis, $62,942; Smith, Dean, NIH, Genetic Analysis of Olfaction, $319,720; Story, Michael, UT Med. Branch at Galveston/NASA, NASA Specialized Center of Research on Radiation Carcinogenesis, $223,657; Tambar, Uttam, NIH, Stereoselective Rearrangements for Synthesis of Bioactive Small Molecules, $310,050; Toto, Robert, NIH, UT STAR - Bridge Funding, $5,339,719; Toto, Robert, NIH, UT-STAR - Bridge Funding - Mentored Career, $455,885; Trivedi, Madhukar, NIH, Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care: EMBARC, $1,964,156; Trivedi, Madhukar, NIH, Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care: EMBARC – Admin. Supplement, $414,116; Trivedi, Madhukar, NIH, Mood Disorders Clinical Intervention Training Program, $130,544.

Willson, James, NIH, Cancer Center Support Grant, $1,425,001; Wolf, Matthias, NIH, Role of Uromodulin in Regulation of Renal Calcium Channel TRPV5, $145,331; Xiao, Guanghua, NIH, Secondary Data Analyses for Substance Abuse Research, $311,627; Xiao, Guanghua, Univ. of North Texas/NIH, Blood-Based Screening Tool for Alzheimer's Disease, $17,313; Yan, Nan, NIH, Understanding Role of TREX1 in Innate Immunity and Autoimmune Diseases, $108,000; Zhang, Xuewu, NIH, Regulation Mechanisms for GTPase Activating Protein Domain of Plexins, $307,751; Zimmern, Philippe, New England Research Institutes/NIH, Urinary Incontinence Treatment Network (UITN); Site 171, $6,650.

Non-Federal Awards

Attanasio, Massimo, Satellite Healthcare, Role of Hedgehog Signaling in Kidney Apoptosis and Fibrosis, $50,000; Bibb, James, American Cancer Society, Development of New Treatment Strategies for MEN2 Cancer, $240,000; Bibb, James (Fellow S. Philibin), Brain & Behavior Research Fndtn., Exploration of Signaling Pathways Targeted by Antipsychotic Drugs, $30,000; Brekken, Rolf, American Cancer Society, Fibulin-5 as Regulator of Tumor Angiogenesis, $180,000; Brewington, Cecelia, Toshiba American Med. Systems, Feasibility of CT Perfusion (CTP) as Noninvasive Method for Characterizing Pulmonary Lesions as Benign or Malignant, $82,034; Buchanan, George (J. Barker, Fellow), PhRMA Fndtn., Zinc-Finger Nuclease Targeted Primary Fibroblasts as Vehicles for Systemic Protein Delivery in Mouse Model of Hemophilia A, $9,000; Burstein, Ezra, Crohn’s & Colitis Fndtn., COMMD Proteins and Regulation of Inflammation in IBD, $128,700; Buszczak, Michael (N. Shalaby, Fellow), American Heart Assn. Southwest, Using Drosophila to Study Role of Histone Deacetylation in Stem Cells, $40,000.

Carroll, Thomas, March of Dimes Fndtn., Delineating Role for Noncanonical WNT Signaling in Kidney Morphogenesis, $111,575; Carroll, Thomas (A. Das, Fellow), American Heart Assn. Southwest, Role of Wnt Signaling in Regulating Kidney Stem Cell Population, $42,000; Carroll, Thomas (X. Pan, Fellow), Natl. Kidney Fndtn., Characterize Cell Movements in Kidney Tubule Elongation, $50,000; Chen, Benjamin, UT Arlington/CPRIT, C2; Live Cell Imaging Core, $100,957; Cheng, Edaire, American Gastroenterological Assn., Differences in Eotaxin-3 Expression in Esophageal Epithelial Cells From Patients With Eosinophilic Esophagitis and Gastroesophageal Reflux Disease, $40,000; Chiang, Cheng-Ming, UT M.D. Anderson/CPRIT, Molecular Mechanisms & Functions of Epigenetic Regulators; Project 2, $97,577; Chook, Yuh Min, Leukemia & Lymphoma Society, Mechanisms of CRM1-Mediated Nuclear Export in Leukemia, $110,000; Cleaver, Ondine (S. Meadows, Fellow), American Heart Assn. Southwest, Elucidating Function of Annexim A3 during Cardiovascular Development, $50,048.

Clegg, Deborah, Klarman Family Fndtn., Estrogens Enhance Therapeutic Effects of Leptin Through Estrogen Receptor-Dependent Mechanisms, $200,000; Clegg, Deborah (R. Nafikov, Fellow), American Heart Assn. Southwest, 25-Hydroxycholesterol-Mediated Protection of Hypothalamic Neurons from High Fat Diet-Induced Oxidative Stress, $42,000; Crandall, Craig (R. Lucas, Fellow), American Heart Assn. Southwest, Cardiovascular, Autonomic and Thermoregulatory Responses to Postmenopausal Hot Flash, $46,796; DeBerardinis, Ralph, Damon Runyon Cancer Research Fndtn., Translational Studies in Cancer Metabolism, $150,000; Dutta, Amal, American Liver Fndtn., Regulation of Biliary Secretion and Bile Information by Ca2+-Activated Cl- Channel TMEM16A, $75,000; Elmquist, Joel (J. Sohn, Fellow), American Diabetes Assn., Identification of Central Serotonergic Pathways that Regulate Energy and Glucose Homeostasis, $42,750; Fish, Jason, UT System, Comparison of IHI Open School to Faculty-Led QI and Patient Safety Curriculum, $47,554.

Galindo, Rene (H. Jiang, Fellow), Howard Hughes Med. Inst., HHMI Medical Research Fellows Program, $39,000; Gao, Fan, American Heart Assn. Natl., Investigation of Effects of Motorized Facilitated Ankle Stretching, $74,662; Hill, Joseph (C. Morales, Fellow), American Heart Assn. Southwest, Histone Deacetylast-Dependent Regulation of Pathological Cardiac Autophagy, $25,000; Hsieh, Jenny (Z. Gao, Fellow), American Heart Assn. Southwest, Exploration of Transcriptional Repressor REST During Basal and Stroke-Induced Neurogenesis, $46,000; Jain, Raksha, Seattle Children’s Research Inst./Cystic Fibrosis, G551D Observational Study, $5,417; Joglar, Jose (M. Lo, Fellow), Medtronic Inc., Medtronic Fellowship, $30,000; Kenkel, Jeffrey, Aesthetic Surgery Education & Research Fndtn., Is Pre-Treatment with Fractional Laser a Safe and Effective Method of Analgesia for Facial Rejuvenation, $17,025; Kraus, William, UT M.D. Anderson/CPRIT, Lonestar Oncology Network for Epigenetics Therapy and Research - Project 1, $175,792.

Liu, Ning, American Heart Assn. Natl., MicroRNA Regulation of Cardiac Stem Cells During Regeneration and Repair, $77,000; Mammen, Pradeep (D. Canseco, Fellow), American Heart Assn. Southwest, Cytoglobin: Novel Hemoprotein Modulating Cardiomyocyte Homeostasis and Survival, $44,000; Marple, Bradley, American Geriatric Society, UT Southwestern Chief Resident Immersion Training Program, $37,500; Matulevicius, Susan, American Coll. of Cardiology, Integrated Assessment of Right-Sided Cardiovascular Performance in Left-Sided Chronic Heart Failure, $65,000; Millner, Lori, Susan G. Komen for the Cure, Ventanilla de Salud Breast Health Pilot Program, $50,000; Mohan, Chandra (S. Pathak, Fellow), Arthritis Fndtn., Novel Gene for Receptor Revision in Mature B-Cells, $50,000; Monteggia, Lisa (E. Na, Fellow), Brain & Behavior Research Inst., Mechanisms Underlying Fast-Acting Antidepressant Responses to Ketamine Using Animal Model of Depression, $30,000.

Morrison, Sean (R. Signer, Fellow), Leukemia & Lymphoma Society, Arf, Stem Cell Function, and Agina, $55,000; Parada, Luis (Y. Jiang, Fellow), Brain & Behavior Research Inst., Histone Methyltransferase Setdb 1 Regulates Depression Related Behavior in the Mouse, $30,000; Powell, Craig (H. Speed, Fellow), Autism Speaks, Preclinical Therapeutic Target Validation of Glutamate Receptors in Shank3 Models of Autism, $56,900; Ranganathan, Rama (F. Poelwijk, Fellow), Helen Hay Whitney Fndtn., Evolutionary Dynamics and Design of Natural Proteins, $50,000; Rothenfluh, Adrian, Brain & Behavior Research Inst., Drosophila as Model Organism for Schizophrenia Endophenotypes, $30,000; Rothermel, Beverly (D. Rotter, Fellow), American Heart Assn. Southwest, Role of RCAN1 in Adipogenesis and Metabolic Syndrome, $44,000; Scherer, Philipp (Q. Wang, Fellow), American Diabetes Assn., Adipocyte Birth, Death and Recruitment During Chronic Excess Caloric Intake, $42,750.

Scherer, Philipp (R. Ye, Fellow), American Heart Assn. Southwest, Adiponectin: Cardioprotective and Hypertrophic Effects, $40,000; Schiller, Joan, Eastern Coop Oncology Group/Frontier Science & Technology, ECOG Clinical Trials - Nonfederal Payments, $2,250; Sreeramoju, Pranavi, UT System, Trial of Positive Deviance for Surgical Inpatients to Reduce Hospital Infections, $40,227; Tamminga, Carol (E. Ivleva, Fellow), Brain & Behavior Research Inst., Examining Medial Temporal Lobe Functional Imaging Memory Phenotypes in Schizophrenia Relatives, $30,000; Thomas, Philip, Cystic Fibrosis Fndtn., Development of Methods and Reagents for Assessing CFTR Folding, $299,416; Umetani, Michihisa, American Diabetes Assn., Modulation of Adiposity 27-Hydroxycholesterol, the First Identified Endogenous SERM, $138,000; Velez, Larissa, Texas Higher Education Coordinating Board, Emergency and Trauma Care Education Partnership Program, $200,105.

Westover, Kenneth, CPRIT, Recruitment of First-Time, Tenure-Track Faculty Members, $869,922; White, Michael (M. Potts, Fellow), Susan G. Komen for the Cure, Genotype-Specific MicroRNA Function in Breast Cancer, $60,000; Winick, Naomi (K. Leger, Fellow), Conquer Cancer Fndtn., Evaluation of MicroRNAs as Novel Markers of Cardiotoxicity in Children Undergoing Anthracycline Therapy for Pediatric Cancer, $50,000; Xing, Chao, American Heart Assn. Natl., Identifying Less Frequent Variants With Large Effect Sizes in Genome-Wide Scans, $77,000; Zhang, Chun-Li, American Heart Assn. Natl., Nuclear Receptor TLX-Dependent Adult Neurogenesis After Stroke, $77,000.


Industry Sponsored Awards, dollar amounts not available – July 2012

Addo, Tayo, Trial of Otamixaban With Unfractionated Heparin + Eptifibatide in Patients With Unstable Angina/Non-ST Segment Elevation Myocardial Infarction Scheduled for Early Invasive Strategy; Bird, John, Study of Viaskin Peanut for Treating Peanut Allergy in Children and Adults; Bowman, Robert, Clinical Investigation of AcrySof IQ ReSTOR Multifocal Toric IOL Model SND1T2; Byerly, Matthew, Study of Hospitalization Rates in Adult Subjects with Schizophrenia Treated for Six Months with Aripiprazole IM Depot Compared With Six Months Retrospective Treatment With Oral Antipsychotics in Naturalistic Community Setting; Chong, Benjamin, Study of AMG 557 in Subjects with Subacute Cutaneous Lupus Erythematosus; Collins, Robert, Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry; Elliott, Jeffrey, RNS60 Compassionate Use in Single Patient with ALS; Gerber, David, Understanding Mechanisms of Acquired Resistance to BIBW2992: Pilot Study; Jain, Mamta, Trial of Maraviroc + Darunavir/Ritonavir vs. Emtricitabine/ Tenofovir + Darunavir/Ritonavir for Antiretroviral-Naive HIV Pts with CCR5-Tropic HIV-1.

Joglar, Jose, Collection of ElectroMagnetic Interference Signals Induced by Electrosurgery Device in Patients with ICDs or CRT-Ds (CollectEMI Study); Lee, William, Follow-up Study of Subjects Achieving Sustained Virologic Response in Gilead-Sponsored Trials in Subjects With Chronic Hepatitis C Infection; Lee, William, Follow-up Study of Subjects Not Achieving Sustained Virologic Response in Gilead-Sponsored Trials in Subjects with Chronic Hepatitis C Infection; Lee, William, Ph3 Study of Boceprivir/Peninterferon Alfa-2a/ribavirin in Chronic HCV Genotype 1 IL28B CC Subjects; Lee, William, Ph4 Study of Telaprevir, Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) in Subjects With Genotype 1 Chronic Hepatitis; Lingvay, Ildiko, Adding Liraglutide to High-Dose Insulin: Breaking the Cycle; Mayo, Marlyn, Ph3 Trial and Long-Term Safety Extension of Obeticholic Acid in Patients With Primary Biliary Cirrhosis; McCulley, James, Study Coordinator Agreement; Meyer, Jeffrey, Ph1 Study of Phosphatidylserine-Targeting Antibody Bavituximab in Combination With Capecitabine and Radiation Therapy for Stage II and III Rectal Adenocarcinoma; Quiceno, Mary, Ph3 Study of Immune Globulin IV 10% for Treatment of Mild to Moderate Alzheimer’s Disease.

Quigley, Raymond, Ph3 Study of Paricalcitol Capsules in Pediatric Subjects Age 10-16 with Stage 5 Chronic Kidney Disease Receiving Peritoneal Dialysis; Reimold, Andreas, Study of Secukinumab at 24 Weeks and Up to Two Years in Patients With Active Rheumatoid Arthritis With Inadequate Response to Anti-Tnfa Agents; Rohrich, Rodney, Evaluation of Pure Hydration With Zinc vs. Placebo for Scar Reduction in Bilateral Breast Surgery Subjects; Sharifi, Nima, Protocol to Provide Expanded Access to MDV3100 and Monitor Its Safety in Patientts With Progressive Castration-Resistant Prostate Cancer Prevention Treated With Docetaxel-Based Chemotherapy; Szmuk, Peter, Study of IV Acetaminophen for Treatment of Acute Pain in Pediatric Patients; Tamminga, Carol, Lurasidone Effects on Tissue Glutamate in Schizophrenia; Toto, Robert, Study of Bardoxolone Methyl in Subjects With Chronic Kidney Disease and Type 2 Diabetes; Verma, Udit, Ph3b Study of Regorafenib in Patientts With Metastatic Colorectal Cancer Who Have Progressed After Standard Therapy; Wise, Carol, Studies of Biology of Identified Genes.