Research Awards - December 2011

Federal Awards

Babb, Tony, NIH, Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss, $381,533; Banerjee, Subhash, Univ. of Toledo/NIH, CORAL - Cardiovascular Outcomes in Renal Atherosclerotic Lesions, $1,070; Beutler, Bruce, Scripps Research Inst./NIH, Systems Approach to Immunity and Inflammation, $2,536,076; Beutler, Bruce, NIH, Mutagenic Analysis of LPS Response, $778,879; Beutler, Bruce, Scripps Research Inst./NIH, Discovery and Analysis of Synthetic TLR Agonists and Antag, $123,828; Bibb, James, NIH, Novel Signal Transduction Mechanisms in Learning and Memory, $353,431; Bowens, Cindy, Children’s Hosp. of Philadelphia/NIH, Impact of Pharmacology on Duration of Ventilation in Patients with Respiratory Failure, $75,000; Browning, Jeffrey, NIH, Role of Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease, $382,177; Burma, Sandeep, NIH, Molecular Mechanisms of GBM Radioresistance and Strategies for Radiosensitization, $296,311.

Chen, Zhijian, NIH, Mechanisms of Protein Kinase Activation by Ubiquitin in NF-kB Pathways, $307,021; Corey, David (K. Gagnon, Fellow), NIH, Activating Gene Expression with Antigene RNAs to Treat Genetic Diseases, $53,042; Courtney, Ardith, Univ. of California, Los Angeles/NIH, Combination Trial of Copaxone plus Estriol in Relapsing Remitting MS - ARRA Stimulus Funding, $3,170; Dewey, Richard, NIH, Clinical Center for Neuroprotection in Parkinson Disease, $111,046; Eisch, Amelia, NASA, Molecular and Cellular Mechanisms of Space Radiation-Induced Changes in Hippocampal-Dependent Behavior, $444,859; Elmquist, Joel, NIH, Leptin Action and Central Melanocortin Systems, $382,793; Falck, J. Russell, New York Medical Coll./NIH, Hormonal Regulation of Blood Pressure, $136,665; Hsia, Connie, NIH, Nanoparticle Drug Delivery in Post-Pneumonectomy Compensatory Lung Growth, $690,051; Idris, Ahamed, NIH, Resuscitation Outcomes Consortium Regional Clinical Center - DFW Center for Resuscitation, $158,709.

Jain, Mamta, Fred Hutchinson Cancer Research Ctr./NIH, FHCRC HVTN 505 Protocol Site Expansion, $1,070,971; Kavalali, Ege (D. Ramirez, Fellow), NIH, Role of SNARE Proteins Vti1a and VAMP7 in Central Synaptic Transmission, $51,326; Kramer, Helmut, NIH, Genetics of Endocytic Trafficking in Drosophila Eye, $285,600; Kraus, William, Univ. of Rochester/NIH, Environmental Influences on Epigenetic Immune Programming, $18,869; Kurian, Benji, Feinstein Inst. for Medical Research/NIH, Recovery After Initial Schizophrenic Episode (RAISE), $203,240; Mahony, Lynn, New England Research Inst./NIH, Pediatric Heart Disease Clinical Research Network, $70,642; Mason, Ralph, NIH, Hypoxia and Radiotherapy: Evaluation and Mitigation in Tumors, $287,345; McAdams, Carrie, NIH, Neurobiology of Social Thinking in Anorexia, $171,492; Michaely, Peter, NIH, Characterization of Role of ARH on LDLR Function, $237,938; Mumby, Marc, NIH, Cell Cycle Regulation by Protein Phosphatase 2A, $276,976.

Olson, Eric (D. Patrick, Fellow), NIH, Regulation of Cardiac Hypertrophy by microRNA-21, $27,630; Paulk, Mary, Dana-Farber Cancer Inst./NIH, Comprehensive Minority Institution/Cancer Center Partnership, $72,618; Perez-Fontan, Julio, NIH, Antecedants Sequelae of Childhood Onset Disease, $432,000; Punaro, Marilynn, Duke Univ. Medical Ctr./NIH, CARRANet: Accelerating Toward Evidence Based Culture in Pediatric Rheumatology - ARRA Stimulus Funding, $442; Raskin, Philip, Case Western Reserve Univ./NIH, Epidemiology of Diabetes Interventions and Complications - Clinical Coordinating Center (EDIC/CC), $22,504; Rosenberg, Roger, Univ. of Washington/NIH, National Alzheimer’s Coordinating Center, $25,000; Ross, Elliott, NIH, G Protein-Coupled Receptors - Structure and Regulation, $396,666; Seemann, Joachim, NIH, Cell Cycle Regulation of Golgi Membrane Dynamics, $285,601; Seidel, Michelle (C. Smith, Fellow), NIH, Analysis of PDFR Alpha Signaling in Cardiac Fibroblast Development and Function, $15,080.

Skapek, Stephen, NIH, ARF Controls Vascular Regression During Eye Development, $277,793; Sternweis, Paul, NIH, Signal Transduction via Receptors and G Proteins, $450,667; Willson, James, Case Western Reserve Univ./NIH, Case GI Spore, $98,268; Zigman, Jeffrey, NIH, Ghrelin’s Role in Mood, $353,431.

Non-Federal Awards

Abrams, John, CPRIT, Deconstructing Oncogenic Activity of p53 Mutations, $262,424; Abrams, John, Welch Fndtn., Apoptosome Control by Tango7/EIF3M Proteins, $50,000; Amatruda, James, CPRIT, Identification of Novel Targets for Therapy of Pediatric Germ Cell Tumors, $350,004; Amatruda, James, CPRIT, Genetic Approach to Target EWS-FLI1 Oncoprotein in Ewing’s Sarcoma, $99,675; Bachoo, Robert, CPRIT, Unraveling Molecular Mechanisms and Biomechanics of Glioblastoma Invasion, $323,682; Bai, Xiaoying, CPRIT, Recruitment of First-Time, Tenure-Track Faculty Members, $800,526; Beutler, Bruce, Bill and Melinda Gates Fndtn., Screen for Proteins with Non-Redundant Function in Immuno-Adjuvant, $1,079,590; Bruick, Richard, Welch Fndtn., Characterization of Iron- and Oxygen-Sensing Switch Regulating Cellular Iron Homeostasis, $50,000; Chalak, Lina, Gerber Fndtn., Rewarming Phase of Hypothermia Therapy to Optimize Outcomes Hypoxic-Ischemic Encephalopathy (HIE), $60,000.

Chen, Zhijian, CPRIT, Biochemical Mechanisms of NF-kB Activation in Cancer Cells, $273,286; Chen, Zhijian, Welch Fndtn., Biochemical Mechanism of NF-kB Inhibition by Deubiquitination Enzymes, $80,000; Chuang, David, Welch Fndtn., Mitochondrial Signaling by Reversible Phosphorylation, $60,000; Cleaver, Ondine, CPRIT, Lumen Formation During Blood Vessel Angiogenesis, $200,000; Cobb, Melanie, CPRIT, Dependence of Small Cell Lung Cancer on Basic Helix-Loop-Helix Transcription Factors Ascl1 and NeuroD1, $399,738; Conrad, Nicholas, CPRIT, Posttranscriptional Regulation of Noncoding RNAs Involved in Epigenetic Regulation of Gene Expression, $100,000; Conrad, Nicholas, Welch Fndtn., Biochemical Analysis of Viral RNA Stability Element with Its Cellular Cofactor, hnRNP C, $50,000; DeBerardinis, Ralph, Welch Fndtn., Dynamic Nuclear Polarization of Small Molecule Metabolic Probes: Novel Reagents for Monitoring Cancer Cell Metabolism, $50,000; DeMartino, George, Welch Fndtn., Mechanisms and Regulation of 26S Proteasome Assembly and Activation, $50,000.

Elmquist, Joel (J. Sohn, Fellow), American Heart Assn. SW, Identification of TRPC Channel Subunits Mediating Serotonin 2C Receptor Action in Hypothalamic POMC Neurons, $45,000; Grishin, Nick, Welch Fndtn., Regulation of Flavocoenzyme Homeostasis, $50,000; Hiesinger, Peter, Welch Fndtn., Role of V0 ATPase SNARE-Mediated Membrane Fusion, $50,000; Hill, Joseph (P. Battiprolu, Fellow), American Heart Assn. SW, Diabetic Cardiomyopathy: Role of Metabolic Stress-Induced Fox01 Activation, $47,000; Holland, William, American Heart Assn. SW, Cardioprotective Effects of Adiponectin-Induced Ceramidase Activity, $70,000; Hsieh, Jenny, Welch Fndtn., Chemical Regulation of Adult Hippocampal Neurogenesis, $50,000; Huang, Jun-Shen, CPRIT, Inhibiting miR-451 as Novel Treatment Modality for Polycythemia, a Pre-Leukemia Disease, $100,000; Jiang, Qiu-Xing, American Heart Assn. SW, Buttressed Lipid Bilayers for Studying Cholesterol Effects on Voltage-Gated Ion Channels, $75,000.

Jiang, Youxing, Welch Fndtn., Structural and Functional Studies of RCK-Regulated Potassium Channel, $60,000; Kim, James, Natl. Lung Cancer Partnership, Stromal Activity of Hedgehog Signaling Pathway in Lung Adenocarcinoma Bearing Mutant K-Ras, $67,777; Kohler, Jennifer, CPRIT, Role of ST6GALNAC5's Sialoside Products in Breast Cancer Metastasis to the Brain, $173,084; Kraus, William (B. Gibson, Fellow), American Heart Assn. SW, PARP-1 Activation and Gene Regulation During TNF Alpha-Stimulated Pro-Inflammatory Response in Cardiomyocytes, $25,000; Liu, Xin, CPRIT, Recruitment of First-Time, Tenure-Track Faculty Members, $500,000; Lum, Lawrence, Welch Fndtn., Modulation of Canonical Wnt Pathway Activity Using Small Molecules, $50,000; Lutter, Michael (H. Cui, Fellow), American Heart Assn. SW, Lateral Hypothalmic Area MC4R Signaling Pathway in Regulation of Diet-Induced Obesity and Food Reward, $45,000.

MacMillan, John, CPRIT, Bacterial Antitermination Elements as Synthetic Tools that Improve Production of Anticancer Compounds, $100,000; Mao, Weihua, CPRIT, Personalized Online Adaptive Radiation Therapy, $362,134; Michaely, Peter, UT M.D. Anderson, Determine Which Domains of Beta2-Spectrin Are Necessary for TGF-beta Signaling, $50,000; Minna, John, Vanderbilt Univ./Lungevity Fndtn., Biomarkers for Personalizing Adjuvant Therapy in NSCLC - Increasing Cures, $100,000; Morrison, Sean (R. Signer, Fellow), Leukemia & Lymphoma Society, Arf, Stem Cell Function, and Agina, $55,000; Rizo-Rey, Jose, Welch Fndtn., NMR Methods to Study membrane Proteins in Lipid Bilayers, $50,000; Russell, David, Welch Fndtn., Structure-Function in Mammalian Etherase Enzymes, $50,000; Scherer, Philipp, Juvenile Diabetes Research Fndtn., Novel Pathways for Expansion of Beta-Cell Mass, $150,000; Sharifi, Nima, Amer Cancer Society, Challenging Assumptions about Castration-Resistance in Prostate Cancer, $157,822.

Shaul, Philip (V. Ulrich, Fellow), American Heart Assn. SW, Role of ApoE and ApoER2 in Regulation of Endothelial Call Pheontype, $25,000; Suel, Gurol, Welch Fndtn., Functional Differences Between Redundant Feedback Loops, $50,000; Tambar, Uttam, Welch Fndtn., Asymmetric Carbon-Carbon Bond Formation with Low Valent Iron Catalysts, $50,000; Terman, Jonathan, Welch Fndtn., Chemistry and Enzymology of MICAL Family Oxidoreductases, $50,000; Tu, Benjamin, David and Lucille Packard Fndtn., Packard Fellowship 2010, $175,000; Tu, Benjamin, CPRIT, Novel Strategy for Attacking Tumors Based on Identification of Fundamental Carbon-Source Signal Driving Cell Growth, $100,000; Wan, Yihong, Welch Fndtn., Biochemical Characterization of Lipid Toxicity Mediated by Maternal PPARy Deficiency, $50,000; Ward Ober, Sally, CPRIT, Targeting HER2 for Cancer Therapy, $402,965; White, Michael, Welch Fndtn., Analysis of Functional Significance of Complex Protein/Protein Interactions, $80,000.

Wu, Jiang, Whitehall Fndtn. Inc., Chromatin Regulation of Neuronal Gene Expression and Function, $75,000; Yanagisawa, Hiromi, American Heart Assn. Natl. Ctr., Role of Fibulin-7, New Member of Fibulin ECM Proteins, in Development and Disease, $80,000; Zhang, Rong (M. Ayaz, Fellow), American Heart Assn. SW, Oxygen Saturation in Brain Vessels Using Susceptibility Mapping, $43,000; Zou, Hui, Welch Fndtn., In-Vivo Assay to Determine Separase Activity in Across the Cell Cycle, $50,000.

Industry Sponsored Awards,
dollar amounts not available

Harker-Murray, Paul, Multicenter Study of Decitabine as Epigenetic Priming w/Induction Chemotherapy in Pediatric Acute Myelogenous Leukemia (AML) Subjects; Hughes, Randall, Ph1/2 Study of PX-866 and Docetaxel in Patients with Solid Tumors; Reimold, Andreas, Ph3 Study to Eval Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE); Schiller, Joan, Ph1-2 Trial of MM-121 in Combination w/Erlotinib in 3 Groups of Patients w/Non-Small Cell Lung Cancer.