Research Awards for September 2011

Federal Awards

Bachoo, Robert, NIH, Genetic Dissection of Glioblastoma: Cell of Origin, $340,837; Banerjee, Subhash, Univ. of Toledo/NIH, CORAL - Cardiovascular Outcomes in Renal Atherosclerotic Lesions (Banerjee), $260; Barton, Theresa, HRSA, Ryan White Program; Youth Angle, $405,008; Blount, Paul, NIH, Molecular Mechanisms of Mechanosensitive Channel Gating, $332,850; Bobulescu, Ion, NIH, Protein Phosphatase Regulation of Principal Renal Sodium Transporter NHE3, $86,847; Booth, Timothy, Natl. Childhood Cancer Fndtn./NIH, Study of Boost Irradiation and Craniospinal Radiotherapy in Medulloblastoma, $3,840; Castrillon, Diego, NIH, LKB1 Tumor Suppressor and Human Cancer, $801,002; Chan, Roger, McGill Univ./NIH, Design, Construction and Evaluation of Implants for Vocal Fold Alteration and Reconstruction, $109,201; Choi, Changho, NIH, In-Vivo Detection of 2-Hydroxyglutarate in Gliomas by Spectroscopic MRI, $172,369; Chook, Yuh Min, Rockefeller Univ./NIH, Nucleocytoplasmic Transport: Target for Cellular Control, $142,650.

Clegg, Deborah, Purdue Univ./NIH, Energy Dysregulation: Behavioral and Biological Signals, $20,532; Cowan, Christopher, NIH, Role of FMRP in Cocaine-Dependent Behavioral Plasticity, $237,750; Cullum, C. Munro, U.S. Dept. of Defense, Validation of Computerized Cognitive Assessment in Cross-Cultural Populations, $283,664; Farrar, John, NIH, Type 1 Interferon-Regulated T Helper Development - Admin Supplement, $169,032; Gazdar, Adi, U.S. Dept. of Defense, Blood Based Biomarkers for Lung Cancer Early Detection and Evaluation of CT Based Lesions, $422,667; Goodman, Joel, Columbia Univ./NIH, Summer Immunology Research Program for High School Science Teachers, $29,532; Green, Carla, NIH, Structure/Function Studies of Mammalian Circadian Clock Proteins, $317,000; Gumbo, Tawanda, NIH, Efflux Pump Inhibitors to Reduce Duration of Antituberculosis Therapy, $471,000; Gupta, Roopali, HRSA, Teaching Interprofessional Learners an Individualized Approach for Geriatric Previouslyentive Medicine, $74,991.

Hall, Christiana, Univ. of Virginia/NIH, Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial, $358,712; Hall, Christiana, Univ. of Cincinnati/NIH, Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH); Subaward #6883, $64,814; Hall, Christiana, Johns Hopkins Univ./NIH, Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR III), $7,850; Hennes, Halim, Baylor College of Medicine/HRSA, Integrating Evidence-Based Pediatric Prehospital Protocols into Practice, $55,118; Holper, Elizabeth, Univ. of Toledo/NIH, CORAL - Cardiovascular Outcomes in Renal Atherosclerotic Lesions (Holper), $800; Hsieh, Jer-Tsong, NIH, Targeting Aggressive Prostate Cancer with Novel Theranostic Nanomedicine, $337,563; Hsieh, Jer-Tsong, UT Arlington/Dept. of Defense, Temperature-Sensitive Polymer Magnetic Nanoparticles to Treat Prostate Cancer, $39,760; Hu, Ming, NIH, Klotho: Therapeutic Agent for Ischemia Reperfusion Induced Acute Kidney Injury, $396,250.

Huang, Hao, NIH, Structural Development of Human Fetal Brain, $383,838; Huber, Kimberly (J. Wilkerson, Fellow), NIH, Regulation of Synapse Elimination by FMRP, $54,734; Igarashi, Peter, NIH, UT Southwestern O'Brien Kidney Research Core Center-Summer Student Supplement, $38,880; Karandikar, Nitin, U.S. Dept. of Defense, Harnessing GPR17 Biology for Treating Demyelinating Disease (Partnering PI with Lu, R.), $158,500; Kowalske, Karen, U.S. Dept. of Education, North Texas Burn Rehabilitation Model System (NTBRMS), $362,499; Kraus, William, NIH, Activity of Nuclear Receptor Coregulators with Chromatin, $387,383; Kraus, William (X. Luo, Fellow), U.S. Dept. of Defense, Role of PARP-1 in Signal-Regulated Transcription in Breast Cancer Cells, $42,773; Lee, William, NIH, Multicenter Group to Study Acute Liver Failure, $1,976,819; Lee, William, NIH, North Texas Hepatitis B Consortium: Clinical Site for Hepatitis B Network, $341,742; Lee, William, NIH, UT Southwestern: Clinical Site for Drug-Induced Liver Injury Network (DILIN); Site 106, $259,664.

Levine, Benjamin, NIH, Aging, Fitness & Failure: Mechanisms of Diastolic Dysfunction - Stability Testing Supplement #2, $13,710; Levine, Beth, UT Medical Branch at Galveston/NIH, Autophagy-Inducing Peptide as Novel Therapeutic for Intracellular NIAID Pathogens, $300,101; Lu, Richard, U.S. Dept. of Defense, Harnessing GPR17 Biology for Treating Demyelinating Disease (Partnering PI with Karandikar, N.), $158,500; Malloy, Craig, NIH, Clinical MR Scanner for Imaging Hyperpolarized Carbon-13, $2,237,277; Marciano, Denise, NIH, Role of p120 Catenin in Metanephric Kidney Development, $90,310; Mason, Ralph, NIH, UT Southwestern Small Animal Imaging Resource (MPI), $18,844; McCavit, Timothy, Washington Univ. in St. Louis/NIH, Silent Cerebral Infarct Multicenter Clinical Trial - ARRA Stimulus Supplement, $19,062; McKnight, Steven (R. Halfmann, Fellow), NIH, Contributions of Protein Aggregation to Gene Regulation and Phenotypic Diversity, $317,000.

Miller, David, Gynecologic Oncology Group/NIH, Gynecologic Oncology Group Studies (Per Capita), $30,070; Miller, David, Washington Univ. in St. Louis /NIH, Methylation Markers for Prognosis in Endometrioid Endometrial Cancers, $9,923; Miller, David, Gynecologic Oncology Group/NIH, Corpus Committee Chair Agreement, $924; Millner, Lori, UT Medical Branch at Galveston/HRSA, Model State Supported Area Health Education Centers Program (MAHEC), $86,189; Mohan, Chandra, NIH, Foreboding Lupus Nephritis in Minority Women, $446,797; Mosconi, Matthew, NIH, Motor Control and Cerebellar Maturation in Autism, $157,148; Pandita, Tej, NIH, 15th International Workshop on Ataxis-Telangiectasia and ATM - India, $10,000; Parada, Luis, NIH, Neurofibromatosis Research Center: From Animal Models to Therapeutics - Entire Project, $1,235,539; Parks, Elizabeth, NIH, TORS 06: Effect of Dietary Macronutrient Composition and Weight Loss on Liver Substrate Metabolism and Liver Fat Content in Humans - Admin Supplement, $75,000.

Pedrosa Moral, Ivan, NIH, Non-Invasive Physiologic Predictors of Aggressiveness in Renal Cell Carcinoma, $312,789; Phillips, Margaret, Medicines for Malaria Venture/NIH, Optimizing Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Malaria, $309,259; Ross, Elliott, NIH, G Protein-Coupled Receptors - Structure and Regulation - Interim Funding Supplement, $128,147; Sharifi, Nima, U.S. Dept. of Defense, Mechanisms of AR Activation with SOD2 Silencing and Implications for Castration-Resistant Prostate Cancer, $136,197; Shay, Jerry, Univ. of Nebraska Med. Ctr./NIH, SPORE in Gastrointestinal Cancer, $118,704; Skinner, Celette, NIH, Parkland-UT Southwestern PROSPR Center: Colon Cancer Screening in Safety Net, $1,248,741; Story, Michael, UT Medical Branch at Galveston/NASA, NASA Specialized Center of Research on Radiation Carcinogenesis, $192,144; Sweeney, John, U.S. Dept. of Defense, Family Studies of Sensorimotor and Neurocognitive Heterogeneity in Autism Spectrum Disorders, $188,387.

Thompson, Laurie, Houston Academy of Medicine/NIH, Health Literacy Outreach to Nurses, Librarians, Community Organizations, and General Public in Dallas and Northeast Texas, $14,988; Torres, Fernando, Johns Hopkins Univ./NIH, Molecular Determinants of Pulmonary Arterial Hypertension, $123,765; Toto, Robert, NIH, North and Central Texas Clinical and Translational Science Initiative - U54-Entire Project, $15,603; Toto, Robert, Univ. of Utah/NIH, Systolic Blood Pressure Intervention Trial (SPRINT) Clinical Center Networks (NHLBI) - ARRA Stimulus funding, $10,080; Trivedi, Madhukar, NIH, Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care: EMBARC, $1,965,463; Trivedi, Madhukar, NIH, Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care: EMBARC - Healthy Control Supplement, $701,690; Trivedi, Madhukar, NIH, Clinical Trial Network: North Texas Node - CTN0048 Cocaine Use Reduction with Buprenorphine, $254,716; Vazquez, Miguel, NIH, Improving CKD Detection and Care in High Risk Underserved Population, $339,551.

Weakley, David, Emory Univ./NIH, Infant Aphakia Treatment Study (IATS), $8,596; Weakley, David, Emory Univ./NIH, Infant Aphakia Treatment Study (IATS), $1,260; Willson, James, U.S. Dept. of Defense, Nanotechnology in Cellular Therapies, $1,398,000; Willson, James, NIH, Cancer Center Support Grant - Data Registration Supplement, $75,000; Willson, James, NIH, Cancer Center Support Grant - Leadership Award Supplement, $50,000; Winick, Naomi, Natl. Childhood Cancer Fndtn./NIH, COG Chair Grant PCR; #1233, $10,000; Wolfe, Gil I., NIH, Network of Excellence in Neuroscience Clinical Trials (NEXT), $317,000; Wright, Woodring, Boston Biomedical Research Inst./NIH, Biomarkers for Therapy of FSHD, $149,069; Wright, Woodring (J. Robin, Fellow), Boston Biomedical Research Inst./NIH, Biomarkers for Therapy of FSHD - PreDoc Fellowship, $17,835; Yin, Helen, NIH, Phosphoinositide Regulation of Golgi, $28,342; Yin, Helen, NIH, Phosphoinositide Regulation of Golgi - Diversity Supplement Lorente, $7,503; Yin, Helen, NIH, Phosphoinositide Regulation of Golgi - Diversity Supplement Gipson, $1,451; Zhang, Chun-Li, NIH, Neurogenesis de Novo in Adult Central Nervous System, $471,000. 

Non-Federal Awards

Abrams, John, Ellison Med. Fndtn., Chromatin Interactions Assembled Through Long-Range p53 Enhancer Activity in Normal and Pathologic Aging, $198,125; Attanasio, Massimo, Satellite Healthcare, Role of Hedgehog Signaling in Kidney Apoptosis and Fibrosis, $50,000; Castrillon, Diego, Texas Higher Education Coordinating Board, Role of Foxo1 in Testicular Stem Cell Maintenance and Differentiation, $90,000; Coppari, Roberto (T. Fujikawa, Fellow), Juvenile Diabetes Research Fndtn., Unraveling Neurocircuitries Mediating Leptin's Anti-Type 1 Diabetes Actions, $48,124; Euhus, David, CPRIT, Cancer Genetics Services for Rural and Underserved Populations in Texas, $539,311; Frohman, Elliot, Cleveland Clinic Fndtn./Natl. Multiple Sclerosis Society, Validation Study of Diffusion Tensor Imaging as Physiologically Relevant Biomarker of Brain Tissue Integrity, $125,400; Galindo, Rene, Burroughs Wellcome Fund, Genetic Dissection of Rhabdomyosarcoma Initiator PAZ-FKHR and PAX-Related Signaling in Skeletal Muscle Development, $140,000.

Goldberg, Matthew, Michael J. Fox Fndtn., Regulation of LRRK2 Membrane Association - Entire Project, $125,000; Goodman, Joel, Howard Hughes Med. Inst., STARS Science Triathlon, $175,620; Huang, Chou-Long, Genzyme Corp., Klotho Protection of Glomerular Proteinuria via TRPC6, $50,000; Kramer, Helmut, Texas Higher Education Coordinating Board, Systems Approach to Define a Novel Pathway Regulating Autophagy, $100,000; Kuro-o, Makoto, Texas Higher Education Coordinating Board, Suppression of Aging and Chronic Kidney Disease by Reducing Intestinal Phosphate Absorption, $80,000; Le, Lu, Burroughs Wellcome Fund, Cell of Origin and Tumor Microenvironment in NF1-Associated Neurofibroma Development, $140,000; MacMillan, John, Texas Higher Education Coordinating Board, Enzyme Catalyzed Halogenation Reactions Using Marine Derived Bacteria, $100,000; Mirzaei, Hamid, CPRIT, Recruitment of Missing Links, $78,942; Monteggia, Lisa, NARSAD, Synaptic Basis of Rapid Antidepressant Action, $50,000.

Morrison, Sean, CPRIT, Recruitment of Established Investigators, $2,000,000; Morrison, Sean (I. Shimada, Fellow), American Heart Assn. Natl. Ctr., Regulation of Reactive Astrocyte Formation by Gamma-Secretase Cleavage Products after CNS Injury, $40,000; Olson, Eric, Donald W. Reynolds Fndtn., MicroRNA Control of Heart Disease: From New Biology to New Therapeutics, $1,080,000; Potts, Ryan, CPRIT, Recruitment of First Time Tenure Track Faculty Members, $515,000; Scott, Daniel, Fndtn. For Surgical Fellowships, Bariatric and Minimally Invasive Surgery, $59,000; Suel, Gurol, James S. McDonnell Fndtn., Nonlinear Systems Dynamics in Differentiation Circuits, $87,717; Sun, Xiankai, Juvenile Diabetes Research Fndtn., Imaging Assessment of Pancreatic Beta-Cell Mass and Function, $251,394; Taurog, Joel, U.S.-Israel Bi-Natl Science Fndtn, Sequence Analysis of Peptides Bound to HLA-B27 in Patients and Transgenic Rats with Spondyloarthritis, $25,000.

Weissler, Jonathan (H. Hatoum, Fellow), Will Rogers Inst., Research Fellowship Program, $80,000; Yu, Gang, Alzheimer’s Assn., Models, Imaging and Drugs for TDP-43 Pathobiology, $66,666; Zhang, Chun-Li, Ellison Med. Fndtn., Genetics Approach to Understanding Neural Stem Cell Aging, $100,000; Zigman, Jeffrey, Univ. of Copenhagen/Novo Nordisk, Enteroendocrine Brain Interactions Controlling Metabolism, Motivation and Mood, $288,135. 

Industry Sponsored Awards
(dollar amounts not available)

Bartolome, Sonja, Evaluation of Safety and Efficacy of Adding UT-15C SR to Pulmonary Arterial Hypertension Patients Currently Receiving Tyvaso; Bartolome, Sonja, Study to Assess Respiratory Tract Adverse Events in Pulmonary Arterial Hypertension Patients Treated with Tyvaso (Treprostinil) Inhalation Solution; Bartolome, Sonja, Study to Assess Safety and Efficacy of Treprostinil to Facilitate Liver Transplantation in Patients with Portopulmonary Hypertension; Collins, Robert, Ph2 Study of Effectiveness of RCHOP with/without VELCADE in Previously Untreated Patients with Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma; Fitzgerald, John, Study to Evaluate Safety, Tolerability and Efficacy of FG-3019 in Subjects with Idiopathic Pulmonary Fibrosis; Gerber, David, Ph2 Study of Erlotinib Plus ARQ197 vs. Single Agent Chemotherapy in Previously Treated KRAS Mutation Positive Subjects with Locally Advnced or Metastasis Non-Small Cell Lung Cancer; Gerber, David, Ph1 Study of Safety and Pharmacokinesis of Escalating Doses of DNIB0600a in Patients with Non-Small Cell Lung Cancer and Platinum-Resistant Ovarian Cancer.

Haley, Barbara, Ph2 Study of Ramucirumab (IMC 1121B or 18F1) in Combination with Capecitabine or Capecitabine Monotherapy in Breast Cancer Previously Treated with Anthracycline and Taxane Therapy; Haley, Barbara, PhII Study of Gemcitabine, Carboplatin and Poly (ADP-Ribose) Polymerase (PARP) Inhibitor BSI-201 (Iniparib) in Neoadjuvant Treatment of Triple-Negative or BRCA Mutation-Associated Breast Cancer; Hennes, Halim, Assessment of AppyScore Rapid Test with Clin PTP Assessment Model for Clinical Management of Children and Adolescents with Symptoms of Acute Appendicitis; Husain, Mustafa, Evaluation of Low Emission NeoSync EEG Synchronized TMS Technology for Treatment of Major Depressive Disorder; Kim, Roy, Random, Controlled Trial of Recombinant IGF-1 for HIV Lipodystrophy; Lee, William, Ph3 Study of Once Daily BI201335 120mg for 24 Weeks and BI201335 240 mg for 12 Weeks in Combination with Pegylated Interferon-a and Ribavirin in Treatment-Naive Patients with Genotype 1 Chronic Hepatitis C Infection; Lee, William, Trial of Efficacy and Safety of DEB025/Alisporivir in Combination with Standard of Care in Hepatitis C Genotype 1 Treatment-Naive Patients.

Raskin, Philip, Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON); Raskin, Philip, Comparison of Long-Acting Basal Insulin Analog LY2963016 to Lantus in Combin with Mealtime Insulin Lispro in Adult Patients with Type 1 Diabetes Mellitus: ELEMENT Study; Raskin, Philip, Study of Dose Effectiveness and Frequency of Administration of AMG 151 in Subjects with type 2 Diabetes Mellitus; Shaul, Philip, Impact of Estradio, SERMs and TSECs on Body Weight Regulation and Insulin Sensitivity in Mice; Thorpe, Philip, Vascular Targeting Agents for Treatment of Diseases.