Research Awards — Feb. 12-18, 2011

Federal Grants

Adinoff, Bryon, NIH, Stress, HPA Axis Dysfunction, and Relapse in Alcoholism, $317,311; Arnoldo, Brett, American Burn Assn./U.S. Dept. of Defense, Clinical Trial of Restrictive vs. Traditional Blood Transfusion Practices in Burn Patients, $2,000; Barton, Theresa, John Snow Inc./HRSA, Building Systems of Prevention through Health Promotion for Women and Girls, $2,500; Berry, Jarett, NIH, Magnetic Resonance Imaging of Carotid Artery Subclinical Artherosclerosis, $132,396.

Bibb, James, NIH, Regulation of Dopamine Neurotransmission by CDK5, $317,925; Bibb, James, NIH, Regulation of Dopamine Neurotransmission by CDK5-Diversity Suppl, $79,128; Bowens, Cindy, Children's Hospital of Philadelphia/NIH, Impact of Pharmacology on Duration of Ventilation in Patients with Respiratory Failure, $50,000; Brekken, Rolf (M. Dellinger, Fellow), U.S. Dept. of Defense, Delineating Effect of Novel Anti-VEGF-A Therapy on Lymphatic System of Immunocompetent Tumor Bearing Mice, $81,000; Brown, E. Sherwood, NIH, Citicoline for Bipolar Disorder and Cocaine Dependence, $314,254.

Byerly, Matthew, Columbia Univ./NIH, 2/2: Comparison of Long-Acting Injectable Medication for Schizophrenia (ACLAIMS), $4,000; Castrillon, Diego, NIH, Mouse Models and Translational Studies of Endometrial Cancer, $295,999; Castrillon, Diego, NIH, Mouse Models and Translational Studies of Endometrial Cancer-Diversity Supplement, $56,536; Cavanagh, Harrison, Jaeb Ctr. for Health/NIH, Cornea Donor Study, $75; Chen, David, NIH, Functions of WRN in Response to DNA Double-Strand Breaks, $293,198.

Chen, Peter, NIH, Epigenetic Gene Regulation by Ocular Environment, $279,774; Chen, Zhijian, NIH, Mechanisms of Protein Kinase Activation by Ubiquitin in NF-kB Pathways, $340,775; Chook, Yuh, NIH, Structures and Mechanisms of Nuclear Import and Export, $279,774; Cobb, Melanie, NIH, Regulation and Function of STE20-Related Protein Kinases, $430,055; Cohen, Jonathan, NIH, Genetic Determinants of Coronary Atherosclerosis, $392,500.

Conrad, Nicholas, NIH, Mechanisms of KSHV Post-Transcriptional Gene Regulation, $3,000; Corey, David, NIH, Recognition of Chromosomal DNA by Chemically Modified Oligonucleotides, $268,583; Crandall, Craig, National Space Biomedical Research Inst., Temperature Regulatory and Cardiovascular Responses to Exercise during Long Duration Space Flight, $54,975; Dowling, Michael, Washington Univ. in St. Louis/NIH, Silent Cerebral Infarct Multicenter Clinical Trial-Neurology Committee, $13,598; Drazner, Mark, Duke Univ./NIH, STICH-Surgical Treatment of Ischemic Heart Failure, $390.

Eisch, Amelia, NIH, Opiates and Adult Neurogenesis, $314,746; Eisch, Amelia, NIH, Opiates and Adult Neurogenesis-Diversity Supplement Rivera, $37,089; Farrar, John, NIH, Type 1 Interferon-Regulated T Helper Development, $320,963; Gardner, Kevin (B. Zoltowski, Fellow), NIH, Structural Dynamics of PAS Domain Containing Transcription Factors, $50,474; Hedayati, Susan, NIH, Randomized Trial of Sertraline Treatment of Depression in Chronic Kidney Disease, $344,738.

Hendrixson, David, U.S. Dept. of Agriculture, Regulation of Capsular Polysaccharide Production in Campylobacter Jejuni and Its Role in Host Interactions, $132,000; Herz, Joachim, NIH, Metabolism of the VLDL Receptor and ApoE Receptor 2, $396,250; Hobbs, Helen, NIH, Role of ABCG5 and ABCG8 in Sterol Metabolism, $398,575; Huber, Kimberly, NIH, Mechanisms of mGluR Function and Dysfunction in Mouse Autism Models, $419,137.

Karandikar, Nitin, NIH, Role of T Cells in Immune Modulation of Multiple Sclerosis, $279,774; Karandikar, Nitin, NIH, Role of T Cells in Immune Modulation of Multiple Sclerosis-Diversity Supplemental Mendoza, $12,357; Lee, William, NIH, Coordinating Ctr. for Drug-Induced Liver Injury Network (DILIN); Site 106, $25,000; Levine, Benjamin, National Space Biomedical Research Inst., Cardiovascular Imaging and Strategies to Mitigate Risk for Cardiac Events in Astronauts during Prolonged Spaceflight, $393,932.

Levine, Benjamin, NASA Johnson Space Ctr., Cardiac Atrophy and Diastolic Dysfunction During and After Long Duration Spaceflight-Core Echo Lab Supplement, $117,720; Martinez, Elisabeth, NIH, Characterization of Biological Activities of Novel Epigenetic Modulators, $295,999; Miller, David, Washington Univ. in St. Louis /NIH, Methylation Markers for Prognosis in Endometrioid Endometrial Cancers, $9,634; Millner, Lori, UT Medical Branch at Galveston/HRSA, Model State Supported Area Health Education Centers Program (MAHEC), $25,017.

Monteggia, Lisa, NIH, MeCP2 Dependent Transcriptional Repression & Neurotransmission, $317,925; Norgard, Michael, NIH, RpoN-RpoS Regulatory Pathway in Borrellia Burgdorferi, $356,625; Norgard, Michael, NIH, Structure and Function of Treponema Pallidum Lipoproteins, $349,718; Norgard, Michael, NIH, RpoN-RpoS Regulatory Pathway in Borrellia Burgdorferi, $3,750.

Orth-Taussig, Kimberly, NIH, Analysis of Orchestrated Cell Death Mediated by Vibrio Parahaemolytics T3SS1, $3,750; Otwinowski, Zbyszek, Argonne Natl. Laboratory/U.S. Dept of Energy, Midwest Center for Structural Genomics, $133,866; Parada, Luis, NIH, Genetic Mouse Models of Glioma, $372,956; Parada, Luis, Mount Sinai School of Medicine/NIH, Neural Substrates of Appetitive Behavior in Mood and Motivation-Project II, $108,252.

Peterson, Gail, Johns Hopkins Univ./NIH, Endogenous Cardiac Glycosides in Development of Cardiovascular Disease in African-Americans with Hypertensive Kidney Disease-ARRA Stimulus Funding, $35,515; Pfeiffer, Julie, NIH, Influence of Host Barriers on Viral Quasispecies Diversity and Pathogenesis, $314,746; Rizo-Rey, Jose, NIH, Synaptotagmin and C2-Domains: Structure & Function, $380,865; Rosenberg, Roger, Univ. of Washington/NIH, National Alzheimer's Coordinating Center, $4,350; Rutherford, Cynthia, UT Health Science Center at Houston/NIH, Prevention of Complications of Bleeding Disorders thru Hemophilia Treatment, $61,856.

Sagalowsky, Arthur, Univ. of Southern California/NIH, MVAC in Organ-Confined Bladder Cancer Based on p53 Status, $10,500; Sanchez, Pablo, RTI International/NIH, NICHD Cooperative Multicenter Neonatal Research Network-Capitation Payments, $6,150; Savani, Rashmin, NIH, ABCA3 and Response to Lung Injury, $392,500; Self, David, NIH, Role of Endogenous Opiate Systems in Cocaine Relapse After Long-Term Abstinence, $317,925; Self, David, NIH, Mechanisms of Altered Dopamine Signaling in Cocaine Addiction, $314,746.

Shay, Jerry, Georgetown Univ. School of Medicine/NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation-Project 1, $191,540; Shay, Jerry, Univ. of Nebraska Med. Ctr./NIH, SPORE in Gastrointestinal Cancer, $117,582; Shay, Jerry, Georgetown Univ. School of Medicine /NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation-Core D, $15,700; Shay, Jerry, Georgetown Univ. School of Medicine /NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation-Core B, $14,130; Shay, Jerry, Georgetown Univ. School of Medicine /NASA, NSCORS: Carcinogenesis and Central Nervous System Risks from Space Radiation-Core A, $7,065; Shay, Jerry (S. Wong, Fellow), U.S. Dept. of Defense, New Telomerase Inhibition Targets for Breast Cancer Therapy, $42,773.

Sperandio, Vanessa, NIH, SdiA Regulation of EHEC Virulence, $343,659; Suel, Gurol, Cornell Univ./Natl. Science Fndtn., CD1 Type 1: Distilling Freeform Natural Laws from Experimental Data-ARRA Stimulus Funding, $90,000; Szmuk, Peter, Children’s Hospital Boston/U.S. Food & Drug Administration, GAS Study: Assessment of Long-Term Neurodevelopmental Outcomes in Pediatric Patients Administered Regional and General Anesthesia as Neonates or Infants, $4,000; Timaran, Carlos, Univ. of Medicine & Dentistry Of N.J./NIH, Carotid Revascularization Endarterectomy vs. Stent Trial (CREST), $8,300; Torres, Fernando, Duke Univ./NIH, Mechanisms of Beta Cell Responses in Autoimmune Disease, $247,721.

Tu, Benjamin, Johns Hopkins Univ./NIH, Coordinating Dynamics of Gene Expression with Cellular Metabolic State, $158,500; Vusirikala, Madhuri, Natl. Marrow Donor Program/NIH, RDSafe: Multicenter Study of Hematopoietic Stem Cell Donor Safety and Quality of Life, $750; Ward Ober, E. Sally, UT Dallas/NIH, Quantitative Aspects of Single Molecule Detection, $20,543; Wolfe, Gil, UNIV OF ALABAMA/NIH, Thymectomy in Non-Thymomatous MG Patients on Prednisone, $75,000; Wolfe, Gil, UNIV OF ALABAMA/NIH, Thymectomy in Non-Thymomatous MG Patients on Prednisone-Per Patient Payments, $500.

Womack, Kyle, Univ. of California, San Diego/NIH, Alzheimer's Disease Neuroimaging Initiative (ADNI), $2,750; Yarovinsky, Felix, NIH, Cellular and Molecular Mechanisms of Host Resistance to Toxoplasma Gondii, $356,625; Yarovinsky, Felix, NIH, Cellular and Molecular Mechanisms of Host Resistance to Toxoplasma Gondii, $3,750; Yu, Hongtao (K. Suel, Fellow), NIH, Uncovering Diverse Mitotic Roles of Cohesin by Induced Protein Inactivation, $50,474.

Non-Federal Grants

Abrams, John, CPRIT, Deconstructing Oncogenic Activity of p53 Mutations, $254,918; Alto, Neal, Welch Fndtn., Structural and Biochemical Analysis of Bacterial Protein Mimicry, $50,000; Altschuler, Steven, Welch Fndtn., Targeting Subpopulation Phenotypes Associated with Drug Resistance, $50,000; Amatruda, James, CPRIT, Identification of Novel Targets for Therapy of Pediatric Germ Cell Tumors, $363,928; Amatruda, James, CPRIT, Genetic Approach to Target EWS-FLI1 Oncoprotein in Ewing's Sarcoma, $97,890.

Bachoo, Robert, CPRIT, Unraveling Molecular Mechanisms and Biomechanics of Glioblastoma Invasion, $294,683; Cadeddu, Jeffrey, UT Dallas/Texas Emerging Technology Fund, Future Semiconductor Commercialization (FUSION), $100,000; Chang, Alice (D. Purohit, Fellow), Endocrine Fellows Fndtn., Effect of Anti-Androgen Therapy on Weight Loss and Adipose Cellularity in Women with Polycystic Ovary Syndrome Undergoing Gastric Band, $15,000; Chen, Zhijian, CPRIT, Biochemical Mechanisms of NF-kB Activation in Cancer Cells, $265,326. Chook, Yuh (X. Dong, Fellow), AMFAR AIDS Research, Structural Mechanisms for Nuclear Export of HIV-1 REV by CRM1, $62,500; Cleaver, Ondine, CPRIT, Lumen Formation During Blood Vessel Angiogenesis, $200,000; Cobb, Melanie, CPRIT, Dependence of Small Cell Lung Cancer on Basic Helix-Loop-Helix Transcription Factors Ascl1 and NeuroD1, $399,999; Conrad, Nicholas, CPRIT, Posttranscriptional Regulation of Noncoding RNAs Involved in Epigenetic Regulation of Gene Expression, $100,000; Coppari, Roberto, American Heart Assn. Natl. Ctr., Physiological Relevance of SIRT1 in Brain on Body Energy Metabolism, $77,000.

Cuthbert, Jennifer, UT System, Just Ask, $215,000; Haller, Ronald, Muscular Dystrophy Assn., Impaired Oxidative Capacity in McArdle Disease: Causes and Treatment, $127,700; Hamann, Heidi, Natl. Lung Cancer Partnership, Sex Differences in Stigma and Shame among Lung Cancer Patients, $50,000; Herz, Joachim, Univ. Of California, San Francisco, Consortium for Frontotemporal Dementia Research, $132,000; Huang, Jun-Shen, CPRIT, Inhibiting miR-451 as Novel Treatment Modality for Polycythemia, a Pre-Leukemia Disease, $100,000.

Kim, Mee, Natl. Ataxia Fndtn., Determination of Secondary Structure of Ataxia-3 by X-ray Crystallography, $30,000; Kliewer, Steven, Welch Fndtn., Role of FGF21 in Mediating Antidiabetic Actions of Thiazolidinedione Drugs, $80,000; Kohler, Jennifer, CPRIT, Role of ST6GALNAC5's Sialoside Products in Breast Cancer Metastasis to the Brain, $166,950; Li, Bing, Welch Fndtn., Biochemical Characterization of Binding of Rpd3S Histone Deacetylase Complex to Methylated Chromatin, $50,000; Mangelsdorf, David, Welch Fndtn., Ligand Binding Properties of Nematode Orphan Nuclear Receptors, $80,000.

Mao, Weihua, CPRIT, Personalized Online Adaptive Radiation Therapy, $381,010; McCulley, James, Research To Prevent Blindness, RPB Unrestricted Research Grant-2011, $100,000; Mineo, Chieko, American Diabetes Assn., Role of Pentraxins and Endothelial Fegamma Receptor 11B in High-Fat Diet-Induced Insulin Resistance, $103,500; Naseem, Rao, American Heart Assn. Natl. Ctr., Calcineurin-Dependent Electrical Remodeling in Cardiac Hypertrophy, $77,000; Norgard, Michael, Welch Fndtn., Biophysical Characterization of Novel Bacterial TRAP Transporter, $60,000.

Olson, Eric (M. Carrer, Fellow), American Heart Assn. South Central, Role of microRNA 378 in Cardiac Metabolism and Hypertrophy, $25,000; Orth-Taussig, Kimberly, Welch Fndtn., Enzymatic and Structural Characterization of AMPylator, Vibrio VopS, $80,000; Pieper, Andrew, NARSAD, Investigation of Efficacy of Small, Drug-Like Pro-Neurogenic Molecules in Animal Model of Schizophrenia, $30,000; Ranganathan, Rama, Welch Fndtn., Principles of Allosteric Control in Proteins, $80,000; Rubin, Craig, Donald W. Reynolds Fndtn., Comprehensive Programs to Stregthen Physician Training in Geriatrics, $494,985.

Sadek, Hesham, Gilead Sciences Inc., Glycolytic Cardiac Stem Cells, $65,000; Scherer, Philipp, UT Dallas/Juvenile Diabetes Research Fndtn., Non-Invasive Imaging Pancreatic Beta Cells Using Novel GLP-1 Constructs, $60,500; Sperandio, Vanessa, Burroughs Wellcome Fund, Interkingdom Signaling in Bacterial Pathogenesis, $40,000; Starr, Adam, Orthopaedic Trauma Assn., Early Psychiatric Intervention after Orthopaedic Trauma: Prosp Rand Double-Blind Placebo Controlled Trial, $49,602; Sun, Xiankai, UT Dallas/ Juvenile Diabetes Research Fndtn., Non-Invasive Imaging of Pancreatic Beta Cells Using Novel GLP-1 Constructs, $110,000.

Timaran, Carlos, American Heart Assn. Natl. Ctr., Community-Based Detection and Treatment of Peripheral Arterial Disease in Hispanics, $77,000; Tu, Benjamin, Damon Runyon Cancer Research Fndtn., Novel Strategy for Attacking Tumors Based on Identification of Fundamental Carbon-Source Signal Driving Cell Growth, $150,000; Tu, Benjamin, CPRIT, Novel Strategy for Attacking Tumors Based on Identification of Fundamental Carbon-Source Signal Driving Cell Growth, $100,000; Walsh, Jennifer, American Academy Of Pediatrics, Transitioning Youth with Special Healthcare Needs, $11,533.

Ward Ober, E. Sally, CPRIT, Targeting HER2 for Cancer Therapy, $391,229; Wight-Carter, Mary, Univ. of North Texas Health Science Ctr./GRADALIS, Analysis of Tissue for Pathology or Abnormality-Agreement for Services, $82,500; Willson, James, American Cancer Society, Institutional Research Grant, $150,000; Winkler, Wade, CPRIT, Bacterial Antitermination Elements as Synthetic Tools that Improve Production of Anticancer Compounds, $100,000; Word, Ruth A. (S. Pathi, Fellow), American Urogynecologic Society Fndtn., Recovery of Anal Sphincter Complex from Birth Trauma: Role of Mesenchymal Stem Cells, $15,000.

Wu, Lani, Welch Fndtn., Signal Processing by Neutrophil Chemotaxis Pathway, $50,000; Wyckoff, Myra (J. Sparks, Fellow), American Academy Of Pediatrics, Randomized, Controlled Pilot Study of Asynchronous Compression and Ventilation Cycles vs. Standard NRP CPR for Resuscitation in Neonatal Swine Asphyxia Model, $9,394; Zhang, Chun-Li, Whitehall Fndtn. Inc., Cellular Plasticity of Adult Brain, $75,000; Zhang, Chun-Li, Welch Fndtn., Biochemical Regulation of Orphan Nuclear Receptor TLX, $50,000.

Industry-Sponsored Awards, dollar amounts not available

Arnold, Susan, Study w/Open-Label Extn Phase to Evaluate Effect of Perampanel (E2007) on Cognition, Growth, Safety, Tolerability and Pharmocokinetics when Administered as Adjunctive Therapy in Adoles (12 to less than 18 yrs) with Inadequately Controlled Partial-Onset Seizures; Bowers, Daniel, Transfusional Iron Overload in Children Treated for Cancer; Byerly, Matthew, Clinical and Biomarker Assessment of Efficacy of Cognitive Remediation in Patients with Schizophrenia Stabilized on Lurasidone.

Castro Borrero, Wanda, Study in Subjects w/Relapsing-Remitting Multiple Sclerosis to Evaluate Safety of 240 mg BG00012 TID Admin as Add-On Therapy to Beta Interferons (IFNB) or Glatiramer Acetate (GA); Crary, Shelley, SIPPET: Inhibitor Development in Previously Untreated Patients or Minimally Blood Component-Treated Patients when Exposed to vonWillebrand Factor-Containing Factor VIII Concentrates and to Recombinant Factor VIII Concentrates; Emslie, Graham, Study of Escitalopram in Children 7-11 yr w/Major Depressive Disorder; Euhus, David, I-SPY2 Trial (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging and Molecular Analysis 2)-FNIH Funding.

Joshi, Girish, Airway Responses During Desflurane Anesthesia via a Laryngeal Mask Airway: Effects of Fentanyl Pretreatment; Khera, Amit, Clinical Outcomes Study of Darapladib vs. Placebo in Subjects Following Acute Coronary Syndrome to Compare Incidence of Major Adverse Cardiovascular Events (MACE) (SOLID-TIMI 52); McCavit, Timothy, Study of Efficacy, Safety and Pharmocokinetics of GMI-1070, a Pan0-Selectin Inhibitor, in Subjects Hospitalized for Sickle Cell Vaso-occlusive Crisis.

McPhaul, Michael, Study of Double-Blind Pasireotide LAR 40 mg and Pasireotide LAR 60 mg vs Open-Label Octreotide LAR or Lanreotide ATG in Patients w/Inadequately Controlled Acromegaly; Miller, Bonnie, Activation of Nrf2 Modulates mRNA Levels of Genes Involved in Lipogenesis; Pandya, Amit, Ascd Dose-Finding Study to Evaluate Preliminary Safety, Efficacy, Toler, Pharmacokinetics and Pharmacodynamics of CC-11050 in Subjects w/Discoid Lupus Erythematosus and SCLE.

Petroll, Matthew, Corneal Rostock Heidelberg Instrument Upgrade; Rockey, Don, Cicletanine in Sinusoidal Endothelial Cells and Portal Hypertension; Szmuk, Peter, Study to Charac Pharmacokinetics and Safety of Oxycodone Hydrochloride q12h Controllrd-Release Tablets (ORF) in Pediatric Patients 6-16 Yrs. Inclusive, who Require Opioid Analgesia; Szmuk, Peter, Study of Safety of Twice Daily Oxycodone Hydrochloride Controlled-Release Tablets in Opioid Experienced Children 6-16 Yrs Inclusive, w/Moderate-Severe Malignant and/or Non-Malignant Pain Requiring Opioid Analgesic.

Timmerman, Robert, Study of Cyberknife Partial Breast Irradiation (PBI) for Early Stage Breast Cancer; Torres, Fernando, AMBITION: Study of First-Line Ambrisentan and Tadalafil Comb Therapy in Sbjs w/Pulmonary Arterial Hypertension; Zellers, Thomas, Melody Transcatheter Pulmonary Valve Post-Approval Study.