Research Awards — May 2010

Federal Awards

Antich, Pietro, NIH/UNT Health Sci. Ctr., Hyaluronan-Mediated Regulation of Langerhans Cells, $17,501; Avery, Leon, NIH, Genetics of Nematode Pharyngeal Muscle Excitability, $297,900; Berry, Jarett, NIH, Magnetic Resonance Imaging of Carotid Artery Subclinical Atherosclerosis, $132,177; Bibb, James, NIH, Novel Signal Tranduction Mechanisms in Learning and Memory, $392,500; Bowens, Cindy Darnell, NIH/Children’s Hospital Boston, Clinical Coordinating Center for Clinical Research Network for Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome, $50,501; Bruick, Richard, NIH, Study of Iron-Responsive E3 Ligase Regulating Mammalian Iron Homeostasis, $314,000.

Burgess, Shawn, NIH, Factors Controlling Metabolic Flux in Liver by NMR Isotopomer Analysis, $28,260; Butovich, Igor, NIH, Biochemistry and Biophysics of Preocular Tear Film, $336,594; Cannon, Stephen, NIH, Molecular Physiology of Myotonia and Periodic Paralysis, $379,108; Chen, David, NIH, Roles of DNA-PK in DNA Double-Strand Break Repair, $40,947; Chook, Yuh Min (Fellow D. Xu), NIH, Database and Prediction Algorithm for Leucine-Rich Nuclear Export Signals, $47,606.

Chuang, David, NIH, Inborn Errors of Metabolism in Cell Culture: ARRA Stimulus Admin. Suppl., $78,860; Cobb, Melanie, NIH, Insulin-Regulated MAP Kinase Pathways: ARRA Stimulus Admin. Suppl., $99,852; Cobb, Melanie, NIH, MAP Kinase in Islet Function, $25,548; Coppari, Roberto, NIH, Physiological Relevance of SIRT1 in Brain on Energy and Glucose Homeostasis, $373,032; Crandall, Craig, NIH, Control of Skin Blood Flow and Sweating in Grafted Skin, $326,046.

de Lemos, James, NIH/Intelligent Optical Systems, Lateral Flow Immunoassay Platform for Multiplexed Cardiac Biomarkers Measurement, $19,986; DeMartino, George, NIH, Function and Regulation of Proteasome: ARRA Stimulus Admin. Suppl., $55,049; Dewey, Richard, NIH/Univ. of Rochester, Parkinson Disease Collaborative Study of Genetic Linkage (PROGENI), $5,275; Drazner, Mark, NIH/Duke Univ. Med. Ctr., STICH-Surgical Treatment of Ischemic Heart Failure, $130; Drazner, Mark, NIH/New England Research Inst., TOPCAT: Treatment of Preserved Cardiac Function Heart Failure With Aldosterone Antagonist, $2,150.

Elmquist, Joel, NIH/Oregon Health & Science Univ., Fat Induced Alterations in Gene Expression in NHP, $235,500; Feranchak, Andrew, NIH, Mechanosensitive ATP Release and Signaling in Cholangiocyte Secretion, $310,860; Fitz, J. Gregory, NIH, Cell Biology Research Improvements and Renovations: ARRA Stimulus Const. Support, $14,954,444; Fitzgerald, John, NIH/Duke Univ. Med. Ctr., Idiopath Pulmonary Fibrosis Clinical Research Network: IPFNET, $5,172; Freeman, Anne, CDC, Capacity-Building Assistance (CBA) to Improve Delivery and Effectiveness of HIV Prevention Services, $576,000.

Freeman, Anne, CDC, STD/HIV Prevention Training Centers, $706,905; Freeman, Anne, NIH/Univ. of Calif., San Francisco, Community-Level HIV Prevention Intervention for Young Black Men, $99,178; Fu, Qi, NIH, Vasomotor Sympathetic Activity During Early Pregnancy in Humans, $185,421; Garg, Abhimanyu, NIH, Genetic and Metabolic Basis of Familial Lipodystrophies, $590,898; German, Dwight, NIH/RW Johnson Fndtn., Angiotensin and Neurodegeneration, $13,472.

Gibson, Jay, NIH, Cortical Circuit Changes and Mechanisms in Mouse Model of Fragile X Syndrome, $290,266; Gill, Michelle, NIH/Univ. of Wisc. – Madison, Inner-City Asthma Consortium (ICAC): Immunologic Approaches to Reduce Asthma; PROSE Pilot Study, $262,505; Graff, Jonathan, NIH, Invertebrate Models of Fat Storage, $446,533; Green, Carla, NIH, Circadian Post-Transcriptional Regulatory Mechanisms, $158,188; Halm, Ethan, NIH, Long-Term Outcomes of Carotid Endarterectomy: Diversity Suppl., $140,554.

Halm, Ethan, NIH, Long-Term Outcomes of Carotid Endarterectomy, $557,923; Henkemeyer, Mark, NIH, Eph-Ephrin Bidirectional Signaling in Visual Development, $377,307; Hilgemann, Donald, NIH, Cardiac Function and PIP2, $381,100; Hill, Joseph, NIH, Foxo: Negative Regulator of Cardiac Hypertrophy, $392,500; Hsia, Connie, NIH, Mechanisms of Compensatory Lung Growth, $410,845.

Huber, Kimberly, NIH, Study of Fragile X Mental Retardation Protein in Synaptic Function and Plasticity: Diversity Suppl., $61,798; Huber, Kimberly, NIH, Study of Fragile X Mental Retardation Protein in Synaptic Function and Plasticity, $330,289; Husain, Mustafa, NIH, Prolonging Remission in Depressed Elderly (PRIDE), $206,304; Idris, Ahamed, NIH, Resuscitation Outcomes Consortium Regional Clinical Center: D/FW Center for Resuscitation, $158,500; Idris, Ahamed, NIH/Univ. of Wash., Hypertonic Resuscitation Following Traumatic Injury, $61,040.

Jiang, Li, NIH, Regulation of Adenylyl Cyclase VII and Its Function in Immune System (MPI), $318,632; Johnson, Jane (Fellow D. Meredith), NIH, Regulation of Ptf1a in Developing Nervous System, $28,080; Johnson, Jane (Fellow M. Borromeo), NIH, Functional Role of Ascl1 in Developing Spinal Cord, $28,272; Kliewer, Steven, NIH, Regulation of Metabolism by Hormone FGF15/19, $373,032; Koh, Andrew, NIH, Mucosal Colonization and Dissemination of P. aeruginosa, $93,536.

Kuro-o, Makoto, NIH, Effects of Klotho Protein on Aging and Metabolism, $312,259; Leitch, Ann Marilyn, NIH/Duke Univ. Med. Ctr., ACOSOG Admin. Coordinating Ctr.; Site 119, $6,000; Leitch, Ann Marilyn, NIH/National Surgical Adjuvant Breast & Bowel, STAR P-2 Trial Service Agreement, $1,200; Lin, Weichun, NIH, Patterning and Formation of Neuromuscular Junction, $340,004; Liu, Qinghua, NIH, Regulatory Mechanisms of RNA Interference, $279,774; Liu, Yi, NIH, Double-Stranded RNA-Mediated Signaling Pathway and Gene Silencing, $279,774.

Lu, Hanzhang, NIH/UT Dallas, Brain and Cognitive Changes After Reasoning or Physical Training in Cognitivity: ARRA Stimulus Challenge Grant, $47,100; Martinez, Elisabeth, NIH, Characterization of Biological Activities of Novel Epigenetic Modulators, $328,888; Mason, Ralph, NIH, UT Southwestern Small-Animal Imaging Resource (MPI), $446,998; McPhaul, Michael, NIH, Minority Predoctoral NLHBI Research Training at UT Southwestern, $118,364; McPhaul, Michael, NIH, Clinical and Basic NIDDK Research Training for Medical Students, $125,389.

Miller, David, NIH/Gynecologic Oncology Group, Gynecologic Oncology Group Studies (per Capita), $5,800; Miller, David, NIH/Gynecologic Oncology Group, Corpus Committee Chair Agreement, $13,200; Mohan, Chandra, NIH, Lupus Genes and B-Cell Signaling, $349,718; Nations, Sharon, NIH/Univ. of Kansas, Phase II Trial of Methotrexate in Myasthenia Gravis, $500; Norgard, Michael, NIH/UT Medical Branch at Galveston, Region VI Center for Biodefense and Emerging Infections; RP008, $367,713.

Olson, Eric (Fellow D. Millay), NIH, Role of microRNA-206 in Skeletal Muscle Regeneration, $50,474; Olson, Eric (Fellow J. O’Rourke), NIH, MicroRNA-29 in Postnatal Skeletal-Muscle Development and Disease, $47,606; Orth-Taussig, Kimberly, NIH, Analysis of Orchestrated Cell Death Mediated by Vibrio Parahaemolytics T3SS1, $392,500; O’Suilleabhain, Padraig, NIH/Mass. General Hosp., Coenzyme Q10 in Huntington’s Disease, $10,110; Petroll, W. Matthew, NIH, Assessment of Corneal Fibroblast Biomechanical Behavior, $388,575.

Punaro, Marilynn, NIH/Duke Clin. Research Inst., APPLE 009: Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Lipitor (A vtorvastatin) in Reducing Progression of Carotid IMT in Early Childhood SLE, $21,000; Rao, Uma, NIH, Neuronal Risk Markers for Nicotine Dependence in Youth, $332,539; Rogers, Zora, NIH/St. Jude Children’s Research Hosp., Stroke With Transfusions Changing to Hydroxyurea, $107,411; Rosen, Michael, NIH, Structural Study of GTPase Regulators and Effectors, $27,052; Rosenberg, Roger, NIH/Univ. of Wash., National Alzheimer’s Coordinating Center, $4,350.

Rosenberg, Roger, NIH/Univ. of Wash., Genomewide Associate Analysis of Alzheimer’s Disease: ARRA Stimulus Funding, $4,790; Rosenfeld, Charles, NIH, Studies of Uteroplacental Circulation, $322,517; Sanchez, Pablo, NIH, NICHD Cooperative Multicenter Neonatal Research Network, $279,979; Scherer, Philipp (Fellow J. Rutkowski), NIH, Adiponectin Transport: Endothelial Modulation of Adipokine Function, $47,606; Scherer, Philipp (Fellow W. Holland), NIH, Synergistic Roles of Adiponectin and PPARgamma in Beta-Cell Survival/Proliferation, $46,268.

Schiller, Joan, NIH/Eastern Co-op. Oncology Grp. Coord. Ctr., ECOG Clinical Trials, $1,500; Seidel, Michelle, NIH, PDGF Receptor Signaling in Mammalian Development, $392,500; Self, David, NIH, Role of Endogenous Opiate Systems in Cocaine Relapse After Long-Term Abstinence, $353,250; Shaul, Philip, NIH, Estrogen Modulation of Endothelial Cell Phenotype, $238,497; Sternweis, Paul, NIH, Signal Transduction via Receptors and G Proteins, $45,035.

Takahashi, Joseph (Fellow V. Kumar), NIH, Characterization and Cloning of Response Psychostimulant Mutant Gridlocked, $57,686; Tamminga, Carol, NIH, Antipsychotic Influence on Altered MTL Neuronal Activity in Schizophrenia, $392,500; Terada, Lance, NIH, p47 Binding Partners in Endothelial Cell Function, $314,000; Thomas, Philip, NIH, Development of Membrane Protein Structure, $330,289; Timmerman, Robert, NIH/Amer. Coll. of Radiology, Radiation Therapy Oncology Group, $9,150.

Vitetta, Ellen (Fellow A. Case), NIH, Model to Develop Peptoid-Based Vaccines, $29,016; Wakeland, Edward, NIH, Defining Genetic Pathways to Severe Systemic Autoimmunity, $604,486; Weakley, David, NIH/JAEB Ctr. For Health, Pediatric Eye Disease Investigator Grp.: Amblyopia Treatment Study, $117; Williams, Kevin, NIH, Genetic Dissection of Endoplasmic Reticulum Stress in POMC Neurons, $116,154; Winick, Naomi, NIH/Natl. Childhood Cancer Fndtn., COG Chair Grant PCR; #1233, $27,300.

Winick, Naomi, NIH/Natl. Childhood Cancer Fndtn., COG Chair Grant; Methotrexate Suppl., $298,485; Womack, Kyle, NIH/Univ. of Calif., San Diego, Alzheimer’s Disease Neuroimaging Initiative, $3,187; Word, Ruth Ann, NIH, Elastic Fiber Homeostasis in Vaginal Wall, $312,259; Wright, Woodring, NIH, Mechanisms of Cellular Immortalization, $232,699; Xie, Xian-Jin, NIH/UTHSC Houston, Correlative Genetic Markers in Childhood Hepatoblastoma, $79,010.

Yin, Helen, NIH, Phosphoinositide Regulation of Golgi - Diversity Suppl., $5,429; Yu, Gang, NIH, Mechanism and Function of Sequential Proteolysis in Health and Disease, $281,033; Yu, Hongtao, NIH, Regulation of Anaphase-Promoting Complex by Spindle Checkpoint: Admin. Suppl., $101,631; Zhang, Rong, NIH, Arterial Aging, Brain Perfusion and Exercise: Impact on Brain Structure and Function, $581,579; Zhang, Rong, NIH/UT Dallas, Impact of Exercise and Engagement on Cognition in Older Adults: ARRA Stimulus Challenge Grant, $153,380.

Zhao, Dawen, NIH, Dynamic Multimodal Imaging of Tumor Hypoxia and Vascular Profiles in Glioblastoma, $8,444; NIH, Ghrelin’s Role in Mood, $392,500.

Nonfederal Awards

Devous, Michael, Alzheimer’s Assn./UT Dallas, Amyloid Deposition, Aging and Neurocognitive Function, $15,625; Gimpel, Nora, UT System/UT San Antonio, Community Medicine Education and Research Training: Innovative Pipeline for Future Primary-Care Physicians, $7,500; Scherer, Philipp, Juvenile Diabetes Research Fndtn., In Vivo Regeneration of Beta Cell Mass After Targeted Apoptosis in Islet, $146,590; Scherer, Philipp, New York State DOH/Albert Einstein Coll. of Med., Identification of Adipocyte Cells in Adipose Tissue Turnover and Obesity, $60,000.

Industry-Sponsored Awards, dollar amounts not available

Choy, H., Phase I, Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases; Gerber, D., A Randomized Phase 2 Study of a Human Anti-PDGFRа Monoclonal Antibody (IMC-3G3) With Paclitaxel/Carboplatin or Paclitaxel/Carboplatin Alone in Previously Untreated Patients With Locally Advanced or Metastatic Non-Smal-Cell Lung Cancer; Haley, B., A Prospective, Randomized, Double-Blind, Stratified, Multi-Center, 2-Arm Trial of the Continued Efficacy and Safety of Zometa (Every Four Weeks vs. Every 12 Weeks) in Patients With Documented Bone Metastases From Breast Cancer.

Hall, C., A Prospective, Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy and Safety of Clazosentan in Reducing Vasospasm-Related Morbidity and All-Cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Endovascular Coiling; Journeycake, J., A Prospective, Multicenter, Open-Label, Phase 3b Study of Human Plasma-Derived Factor XIII Concentrate in Subjects With Congenital Factor XIII Deficiency; Modur, P., A Historical-Controlled, Multicenter, Double-Blind, Randomized Trial to Assess the Efficacy and Safety of Conversion to Lacosamide 400mg/day Monotherapy in Subjects With Partial-Onset Seizures.

Modur, P., A Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel-Group Study to Evaluate the Efficacy and Safety of E2007 Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures; Novakovic, R., The START Trial: Clinical Outcome in Acute Stroke Treatment After Image Guided Patient Selection for Interventional Revascularization Therapy; Patel, A., A Phase 2, Open-Label, Multicenter Study to Assess the Safety and Efficacy of Certolizumab Pegol in Children and Adolescents With Active Crohn’s Disease (NURTURE Study).

Race, E., A Phase 2b, Randomized, Double-Blinded, 48-Week, Multicenter, Dose-Response Study of Ibalizumab Plus an Optimized Background Regimen in Treatment-Experienced Patients Infected With HIV-1 (Amended to 24-Week Study); Raskin, P., Skin Fluorescence and Type 1 Diabetes Complications: A New Marker of Complications Risk; Raskin, P., A Multicenter, Open-Label, Randomized, Parallel Group, Dose-Ranging, Pharmacodynamic Phase II Trial to Determine the Effects of Bardoxolone Methyl (RTA 402, Amorphous Dispersion) on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease (eGFR 15-45 mL/min/1.73M2).

Stoll, M., CARRA Enhanced Drug Safety Surveillance Project in Juvenile Rheumatoid and Idiopathic Arthritis; Torres, F., A 12-Week, Double-Blind, International, Multicenter, Dose-Response Study of the Safety and Efficacy of Beraprost Sodium Modified Release in Patients With Pulmonary Arterial Hypertension; Torres, F., An Open–Label Extension of BPS-MR-PAH-203 in Pulmonary Arterial Hypertension Patients; Zerwekh, J., Potassium Magnesium Citrate Bioavailability After Single Dose Oral Ingestion of 60 mEq Potassium, 30 mEq Magnesium, 90 mEq of Citrate.