Featured Publications

Monitoring FoxO1 localization in chemically identified neurons.

Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK J. Neurosci. 2008 Dec 28 50 13640-8

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis.

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK Neuron 2008 Nov 60 4 582-9

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress.

Lutter M, Sakata I, Osborne-Lawrence S, Rovinsky SA, Anderson JG, Jung S, Birnbaum S, Yanagisawa M, Elmquist JK, Nestler EJ, Zigman JM Nat. Neurosci. 2008 Jul 11 7 752-3

Central nervous system regulation of energy metabolism: ghrelin versus leptin.

Nogueiras R, Tschöp MH, Zigman JM Ann. N. Y. Acad. Sci. 2008 Apr 1126 14-9

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.

Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB Cell Metab. 2007 May 5 5 383-93

Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats.

Clegg DJ, Brown LM, Zigman JM, Kemp CJ, Strader AD, Benoit SC, Woods SC, Mangiaracina M, Geary N Diabetes 2007 Apr 56 4 1051-8

In search of an effective obesity treatment: a shot in the dark or a shot in the arm?

Zigman JM, Elmquist JK Proc. Natl. Acad. Sci. U.S.A. 2006 Aug 103 35 12961-2

Serotonin reciprocally regulates melanocortin neurons to modulate food intake.

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA Neuron 2006 Jul 51 2 239-49

Expression of ghrelin receptor mRNA in the rat and the mouse brain.

Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK J. Comp. Neurol. 2006 Jan 494 3 528-48

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis.

Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Elmquist JK, Lowell BB Neuron 2006 Jan 49 2 191-203