Featured Publications

5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver.

Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK Nat. Neurosci. 2010 Dec 13 12 1457-9

Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus.

Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ Neuroscience 2010 Nov 170 4 1065-79

PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis.

Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK Cell Metab. 2010 Jul 12 1 88-95

A beta3-adrenergic-leptin-melanocortin circuit regulates behavioral and metabolic changes induced by chronic stress.

Chuang JC, Krishnan V, Yu HG, Mason B, Cui H, Cui H, Wilkinson MB, Zigman JM, Elmquist JK, Nestler EJ, Lutter M Biol. Psychiatry 2010 Jun 67 11 1075-82

Chronic social defeat stress disrupts regulation of lipid synthesis.

Chuang JC, Cui H, Mason BL, Mahgoub M, Bookout AL, Yu HG, Perello M, Elmquist JK, Repa JJ, Zigman JM, Lutter M J. Lipid Res. 2010 Jun 51 6 1344-53

Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility.

Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK Cell Metab. 2010 Apr 11 4 286-97

Ghrelin's Roles in Stress, Mood, and Anxiety Regulation.

Chuang JC, Zigman JM Int J Pept 2010 2010

Characterization of a novel ghrelin cell reporter mouse.

Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM Regul. Pept. 2009 Jun 155 1-3 91-8

Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention.

Davies JS, Kotokorpi P, Eccles SR, Barnes SK, Tokarczuk PF, Allen SK, Whitworth HS, Guschina IA, Evans BA, Mode A, Zigman JM, Wells T Mol. Endocrinol. 2009 Jun 23 6 914-24

Cardiovascular treatment gaps: closing, but slowly.

Selak V, Rafter N, Parag V, Tomlin A, Vander Hoorn S, Dovey S, Rodgers A N. Z. Med. J. 2009 Apr 122 1293 3564