Sherri Osborne-Lawrence, M.S.
Senior Research Scientist and Lab Manager
Sherri was born in Texas and has lived here all of her life. She received her B.A. degree in Biology from Austin College in Sherman, TX, and an M.S. degree in Molecular & Cell Biology from UT Dallas. She has worked in five laboratories at UT Southwestern Medical Center. Sherri's initial research projects involved positional cloning of genes involved in rheumatoid arthritis and early-onset familial breast cancer. After a few years assisting with the final stages of sequencing for the Human Genome Project, she focused on discovering how endothelial cell dysfunction leads to cardiovascular disease, with particular interests in estrogen modulation as well as the effects of C-reactive protein. Sherri joined the Zigman Lab in 2006 as Senior Research Scientist and Lab Manager, and has now expanded her interests to include ghrelin and its effects on metabolic pathways. Among many other contributions, Sherri has designed and generated several new mouse lines currently in use in the lab and by our collaborators.
Bharath Mani, Ph.D.
Bharath was born and raised in Namakkal, a small town in the southern state of Tamil Nadu, India. Bharath’s initial training was at Tamil Nadu Veterinary and Animal Sciences University in Chennai, India, where he earned a B.VS.c. in Veterinary Sciences and an M.S. in Pharmacology. Afterwards, Bharath worked as a research scientist in India, where he was involved in conducting pre-clinical efficacy and toxicity studies of new chemical entities to treat cardiovascular diseases. In July of 2006, Bharath moved to Chicago and enrolled in the pharmacology graduate program at Loyola University Chicago. Bharath worked in the laboratory of Dr. Kenneth Byron to understand the regulation of vascular tone by ion channels in smooth muscle cells to receive his Ph.D. in 2012. To complement his training in cardiovascular pharmacology, Bharath wanted a broad-based training in metabolic syndrome, an important contributor to cardiovascular risk. So, he joined the Zigman Lab in May 2012 and has been working to understand mechanisms regulating ghrelin secretion and action. Bharath spends a lot of time with his family and is interested in exploring different cultures and food. Bharath is a profound follower of cricket, the most revered sport in India.
Emily C. Bruggeman, M.S., Ph.D.
Postdoctoral Research Fellow
Emily grew up in the Blue Ridge mountains of Western North Carolina, and earned her B.A. in Psychology from the University of North Carolina at Asheville. She began her graduate studies in Dr. Marise Parent’s lab at Georgia State University in Atlanta, where she studied the memory-impairing effects of high-energy diets. Her projects were aimed at understanding the effects of a high fructose diet, as well as fish oil supplementation, on brain biochemistry and cognition. She earned her M.S. degree in Neuroscience in 2011, and then joined Dr. Bingzhong Xue’s lab to acquire more advanced molecular techniques with an emphasis on epigenetics. For her dissertation, Emily investigated the role of neuronal DNA methyltransferase 1 in energy homeostasis using transgenic mouse models, and she received her Ph.D. in Neuroscience in 2016. Emily joined the Zigman lab in July 2016 to continue studying energy regulation, targeting the role of ghrelin in central and peripheral tissues. When she is not in the lab, Emily enjoys cooking, trying new wines, and being outdoors.
Deepali Gupta, Ph.D.
Postdoctoral Research Fellow
Deepali was born in Chhattisgarh, a tribal state in the central part of India. She received her Bachelor in Pharmacy from Rajiv Gandhi Technical University in 2008 and Master in Pharmacy from BITS-Pilani, Pilani Campus, India in 2011. During her Master’s dissertation program mentored by Prof. Mahesh, she studied the role of serotonin signaling and hypothalamic-pituitary-adrenal axis dysregulation in depression. Later, she enrolled in the doctoral program at BITS-Pilani and continued to work under the guidance of Prof. Mahesh . Her doctoral research project was aimed at investigating the role of serotonin type-3 (5-HT3) receptor signaling in the pathogenesis of type-1 diabetes-induced depression and the antidepressant activity of novel 5-HT3 receptor antagonists. Deepali joined the Zigman lab in January 2017 to further explore pathogenic pathways involved in depression, in particular, those modulated by the ghrelin system. When not in the lab, she likes cooking and chatting with her family and friends.
Nathan Metzger, M.S.
Research Assistant I
Nathan was born and raised in Apple Valley, MN. He obtained his BS in Community Health (2012) and Biomedical Science (2012) and his MS in Cell and Molecular Biology (2014) from Saint Cloud State University in Saint Cloud, MN. His research background includes having studied the post-translational modifications of a family of proteins collectively known as PGC-1. Specifically, identifying modifiers, locating binding sites, and exploring their effects on PGC-1 expression and activity. He relocated to Fort Worth, TX in the summer of 2016, after which he joined Dr. Zigman's lab. When he is not in the lab exploring the mysteries of life, he enjoys playing League of Legends and spending time with his wife.