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Research

Research

Our laboratory investigates the molecular mechanisms underlying the pathogenesis of sepsis. We use the heart as a model, since cardiac dysfunction is a vital component of multi-organ failure during sepsis.

By combining approaches of molecular biology, biochemistry, histology, and physiology assessments, we aim to define the role of mitochondrial abnormality and production of reactive oxygen species (mtROS) in inciting cardiac inflammation and autophagy in preclinical models.

To explore therapeutic options, we are evaluating whether targeted inhibition of mtROS provides a powerful therapeutic potential for sepsis.