B lymphocytes, Antigen receptors, Immunoglobulin isotype switch recombination, NK Cells, Cell-cell interactions
My laboratory is interested in understanding the cellular and molecular regulation of immunoglobulin production in response to pathogens. The broad aim of our studies is to further the understanding of the regulatory circuits between two arms of the immune system.
Specifically, we are investigating the mechanism by which signals transmitted by natural killer (NK) cells, an important component of the innate immune system, modulate the activation and further differentiation of B lymphocytes, a key player of the specific immune system. Conversely we are also studying the effect of B lymphocytes on NK cell cytokine secretion.
Ongoing studies also probe into the transcriptional control of immunoglobulin gene expression during B cell differentiation.