Publications for Jun Wu, Ph.D.

  1. Bogliotti YS*., Wu, J*#., Vilarino M., Okamura D., Soto DA., Zhong C., Sakurai M., Sampaio RV., Suzuki K., Izpisua Belmonte, JC#., Ross, PJ#. (2018) Efficient derivation of stable primed pluripotent embryonic stem cells from bovine blastocysts. Proc. Natl. Acad. Sci. U.S.A. (in press)
  2. Wang S., Wu, J#., Liu GH#. (2018) First stem cell transplantation to regenerate human lung. Protein Cell
  3. Wu, J*., Vilarino, M*., Suzuki, K*., Okamura, D., Bogliotti, YS., Park, I., Rowe, J., Bret McNabb, B., Ross, PJ#., Izpisua Belmonte, JC#. (2017) CRISPR-CAS9 mediated one-step disabling of pancreatogenesis in pigs. Scientific Report 7, Article number:10487.
  4. Ma, H*., Marti-Gutierrez, N*., Park, S.-W*., Wu, J*., Lee, Y., Suzuki, K., Koski, A., Ji, D., Hayama, T., Ahmed, R., et al. (2017). Correction of a pathogenic gene mutation in human embryos. Nature 548 (7668), 413-419.
  5. Gil, M.A., Martinez, C.A., Nohalez, A., Parrilla, I., Roca, J., Wu, J., Ross, P.J., Cuello, C., Izpisua, J.C., and Martinez, E.A. (2017). Developmental competence of porcine genome edited zygotes. Reprod. Dev. 84 (9), 814-821
  6. Takahashi, Y., Wu, J., Suzuki, K., Martinez-Redondo, P., Li, M., Liao, H.-K., Wu, M.-Z., Hernandez-Benitez, R., Hishida, T., Shokhirev, M.N., et al. (2017). Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells. Science 356, 503–508.
  7. Yang, Y*., Liu, B*., Xu, J*., Wang, J*., Wu, J*., Shi, C., Xu, Y., Dong, J., Wang, C., Lai, W., et al. (2017). Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell 169, 243–257.e25.
  8. Ren, R*., Deng, L*., Xue, Y*., Suzuki, K*., Zhang, W., Yu, Y., Wu, J., Sun, L., Gong, X., Luan, H., et al. (2017). Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research 27, 483–504.
  9. Wu, J., Platero-Luengo, A., Sakurai, M., Sugawara, A., Gil, M.A., Yamauchi, T., Suzuki, K., Bogliotti, Y.S., Cuello, C., Morales Valencia, M., et al. (2017). Interspecies Chimerism with Mammalian Pluripotent Stem Cells. Cell 168, 473–486.e15.
  10. Wu, J., Greely, H., Jaenisch, R., Nakauchi, H., Rossant, J., Izpisua Belmonte, J.C. (2016). Stem Cells and Interspecies Chimeras Nature 540, 51-59
  11. Kang, E., Wu, J., Gutierrez, N.M., Koski, A., Tippner-Hedges, R., Agaronyan, K., Platero-Luengo, A., Martinez-Redondo, P., Ma, H., Lee, Y., et al. (2016). Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations. Nature 540, 270-275
  12. Suzuki, K*., Tsunekawa, Y*., Hernandez-Benitez, R*., Wu, J*., Zhu, J., Kim, E., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., et al. (2016). In vivo genome editing via CRISPR-Cas9 mediated homology-independent targeted integration. Nature 540, 144-149
  13. Wu, J., Luengo, P., Gil, M.A., Suzuki, K., Cuello, C., Valencia, M.M., Parrilla, I., Martinez, C.A., Nohalez, A., Roca, J., et al. (2016). Reproduction in Domestic Animals 51(S2), 18-24
  14. Wu, J*., Ocampo, A*., Izpisua Belmonte, J.C. (2016). Cellular metabolism and induced pluripotency. Cell 166, 1371-1385
  15. Li, Z.W*., Araoka, T*., Wu, J*., Liao, K., Li, M., Lazo, M., Zhou, B., Sui, Y.H., Wu, M.Z., Tamura, I., et al. (2016). 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitor. Cell Stem Cell 19, 516–529.
  16. Suzuki A., Hrasaki M., Hishida T., Wu J., Okamura D., Nishimoto M., Nakachi Y., Mizuno Y., Okazaki Y., Matsui Y., et al. (2016). Identification of a molecular blockade of meiotic entry in ESCs. Nature Communications 7, 11056
  17. Wu J. and Izpisua Belmonte J.C. (2016). The molecular harbingers of early mammalian embryo patterning. Cell 165, 13-15.
  18. Fu, L., Xu, X., Ren, R., Wu, J., Zhang, W., Yang, J., Ren, X., Wang, S., Zhao, Y., Sun, L., et al. (2016). Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs. Protein Cell 7, 210-221
  19. Wu, J.# and Izpisua Belmonte J.C.# (2016). Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts. Transgenic Res 1–10.
  20. Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., et al. (2016). SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Research 26, 190–205.
  21. Duan, S*., Yuan, G*., Liu, X*., Ren, R., Li, J., Zhang, W., Wu, J., Xu, X., Fu, L., Li, Y., et al. (2015). PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nature Communications 6, 10068.
  22. Wu, J. and Izpisua Belmonte J.C. (2015). Metabolic exit from naive pluripotency. Nature Cell Biology 17, 1519–1521.
  23. Brennand, K.J*., Marchetto, M.C*., Benvenisty, N., Brüstle, O., Ebert, A., Izpisua Belmonte, J.C., Kaykas, A., Lancaster, M.A., Livesey, F.J., McConnell, M.J., McKay, R.D., Morrow, E.M., Muotri, A.R., Panchision, D.M., Rubin, L.L., Sawa, A., Soldner, F., Song, H., Studer, L., Temple, S., Vaccarino, F.M., Wu, J., Vanderhaeghen, P., Gage, F.H#., Jaenisch, R#., 2015. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. (2015). Stem cell reports 5, 933–945.
  24. Wu, J. and Izpisua Belmonte, J. C. (2015). Dynamic Pluripotent Stem Cell States and Their Applications. Cell Stem Cell 17, 509–525.
  25. Ma, H., Folmes, C.D.L., Wu, J., Morey, R., Mora-Castilla, S., Ocampo, A., Ma, L., Poulton, J., Wang, X., Ahmed, R., et al. (2015). Metabolic rescue in pluripotent cells from patients with mtDNA disease. Nature 524, 234–238.
  26. Izpisua Belmonte, J.C., Callaway, E.M., Caddick, S.J., Churchland, P., Feng, G., Homanics, G.E., Lee, K.-F., Leopold, D.A., Miller, C.T., Mitchell, J.F., Mitalipov, S., Moutri, A.R., Movshon, J.A., Okano, H., Reynolds, J.H., Ringach, D., Sejnowski, T.J., Silva, A.C., Strick, P.L., Wu, J., Zhang, F., (Authors in alphabetical order). Brains, Genes, and Primates. (2015). Neuron 86, 617–631.
  27. Wu, J*., Okamura, D*., Li, M., Suzuki, K., Luo, C., Ma, L., He, Y., Li, Z., Benner, C., Tamura, I., et al. (2015). An alternative pluripotent state confers interspecies chimaeric competency. Nature 521, 316–321.
  28. Reddy, P*., Ocampo, A*., Suzuki, K., Luo, J., Bacman, S.R., Williams, S.L., Sugawara, A., Okamura, D., Tsunekawa, Y., Wu, J., et al. (2015). Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing. Cell 161, 459–469.
  29. Deng, L*., Ren, R*., Wu, J*., Suzuki, K., Izpisua Belmonte, J.C., Liu, G-H., (2015). CRISPR/Cas9 and TALE: beyond cut and paste. Protein Cell 6, 157-159.
  30. Wang, L., Wu, J., Fang, W., Liu, G.-H., Izpisua Belmonte, J.C. (2015). Regenerative medicine: targeted genome editing in vivo. Cell Research 25, 271–272.
  31. Wu, J. and Izpisua Belmonte, J.C. (2014). Stem cells: A designer’s guide to pluripotency. 516, 172-173
  32. Yan, H.-X., Wu, H.-P., Zhang, H.-L., Ashton, C., Tong, C., Wu, J., Qian, Q.-J., Wang, H.Y., Ying, Q.L., (2013). DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats. Oncogene 32, 4565–4571.
  33. Masuda, S., Wu, J., Hishida, T., Pandian, G.N., Sugiyama, H., Izpisua Belmonte, J.C., (2013). Chemically induced pluripotent stem cells (CiPSCs): a transgene-free approach. Journal of Molecular Cell Biology 5, 354–355.
  34. Kim, H*., Wu, J*., Ye, S*., Tai, C.-I., Zhou, X., Yan, H., Li, P., Pera, M., Ying, Q.-L., (2013). Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nature Communications 4, 2403.
  35. Stamp, L.A*., Braxton, D.R*., Wu, J*., Akopian, V*., Hasegawa, K*., Chandrasoma, P.T., Hawes, S.M., McLean, C., Petrovic, L.M., Wang, K., Pera, M.F., (2012). The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin. Stem Cells 30, 1999–2009.
  36. Wu, J*., Cho, H.P*., Rhee, D.B., Johnson, D.K., Dunlap, J., Liu, Y., Wang, Y., (2008). Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication. The Journal of Cell Biology 181, 475–483.
  37. Zou, Y., Wu, J., Giannone, R.J., Boucher, L., Du, H., Huang, Y., Johnson, D.K., Liu, Y., Wang, Y., (2007). Nucleophosmin/B23 Negatively Regulates GCN5-dependent Histone Acetylation and Transactivation. Journal of Biological Chemistry 283, 5728–5737.
  38. Giannone, R.J., McDonald, W.H., Hurst, G.B., Huang, Y., Wu, J., Liu, Y., Wang, Y., (2007). Dual-tagging system for the affinity purification of mammalian protein complexes. BioTechniques 43, 296–298– 300
  39. Jackson, M.R., Beahm, R., Duvvuru, S., Narasimhan, C., Wu, J., Wang, H.-N., Philip, V.M., Hinde, R.J., Howell, E.E., (2007). A Preference for Edgewise Interactions between Aromatic Rings and Carboxylate Anions:  The Biological Relevance of Anion−Quadrupole Interactions. Phys. Chem. B 111, 8242–8249.
  40. Gomez, M., Wu, J., Schreiber, V., Dunlap, J., Dantzer, F., Wang, Y., Liu, Y., (2006). PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres. Biol. Cell 17, 1686–1696.
  41. Wang, Y., Erdmann, N., Giannone, R.J., Wu, J., Gomez, M., Liu, Y., (2005). An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres. Natl. Acad. Sci. U.S.A. 102, 10256–10260.
  42. Strader, M.B., Chopra, S., Jackson, M., Smiley, R.D., Stinnett, L., Wu, J., Howell, E.E., (2004). Defining the Binding Site of Homotetrameric R67 Dihydrofolate Reductase and Correlating Binding Enthalpy with Catalysis. Biochemistry 43, 7403–7412.

* Co-first authors
# Co-corresponding authors)