UT Southwestern Medical Center researchers have identified an ion channel required for brain cells to suppress eating behavior in response to the hormone leptin or to the anti-obesity drug lorcaserin.
Ion channels are tunnel-shaped passageways on the surface of neurons through which charged particles, or ions, can travel in and out of the cell.
A deeper understanding of this brain-metabolism relationship could someday lead to new, better targeted treatments for obesity or diabetes, said lead author Dr. Kevin Williams, Assistant Professor of Internal Medicine at UT Southwestern and senior author of the study, published recently in Cell Reports.
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