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|Graduate Students||Postdoctoral Fellows||Researchers / Staff||Principal Investigator|
Jonathan Cooper – Cancer Biology
Education B.S. – Biology, 2010, Dallas Baptist University
Research Interests: Exploring the intersection between cellular growth and renewal signaling pathways and their dysregulation in cancer. Specifically, I am interested in investigating the key players in cellular responses to nutrient availability and probing for selective vulnerabilities in cancers harboring aberrant nutrient sensing.
Cooper, J. M., Bodemann, B. O., and White, M. A. (2013). The RalGEF/Ral pathway: evaluating an intervention opportunity for Ras cancers. The Enzymes 34, 137-157.
Banu Eskiocak – Cancer Biology
Education: D.D.S. – Dentistry, 2007, Cukurova University, Adana, Turkey
Research Interests: Understanding the regulation of proliferation and survival signals in melanoma. As one of the most aggressive tumors, melanoma metastasis to distant organs correlates with less than 9 months of median survival. Molecular heterogeneity in melanoma limits the effectiveness of conventional therapies. This, together with fast development of resistance to next generation drugs, raises the need for additional therapeutic strategies. To help address this need, we are combining genome-wide RNAi screens in metastatic melanoma cell lines with whole genome copy number analyses of human melanoma samples in order to isolate compendiums of gene products responsible for the bypass of normal proliferation and survival restraints during melanomagenesis. Moreover, to be able to develop therapies against these targets, we apply regularized linear regression models that return sparse expression signatures predictive of target sensitivity, which by nature, may serve as molecular response predictors.
Eskiocak, B., Ali, A., and White, M.A. (2014). The Estrogen-Related Receptor alpha Inverse Agonist XCT 790 Is a Nanomolar Mitochondrial Uncoupler. Biochemistry 53, 4839-4846.
Kim, H.S., Mendiratta, S., Kim, J., Pecot, C.V., Larsen, J.E., Zubovych, I., Seo, B.Y., Kim, J., Eskiocak, B., Chung, H., McMillan, E., Wu, S., De Brabander, J., Komurov, K., Toombs, J.E., Wei, S., Peyton, M., Williams, N., Gazdar, A.F., Posner, B.A., Brekken, R.A., Sood, A.K., Deberardinis, R.J., Roth, M.G., Minna, J.D., White, M.A. (2013). Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell 155, 552-566.
Acharya, A., Baek, S.T., Huang, G., Eskiocak, B., Goetsch, S., Sung, C.Y., Banfi, S., Sauer, M.F., Olsen, G.S., Duffield, J.S., Olson, E.N., Tallquist, M.D. (2012). The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 139, 2139-2149.
Acharya, A., Baek, S.T., Banfi, S., Eskiocak, B., and Tallquist, M.D. (2011). Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney. Genesis 49, 870-877.
Mellgren, A.M., Smith, C.L., Olsen, G.S., Eskiocak, B., Zhou, B., Kazi, M.N., Ruiz, F.R., Pu, W.T., and Tallquist, M.D. (2008). Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circulation research 103, 1393-1401.
Ji Mi Kim – Cancer Biology
Education: B.S., 2004, Korea Advanced Institute of Science and Technology (KAIST); M.S., 2007, Seoul National University
Research Interests: Investigating selective dependency of NSCLC cell lines on nuclear transport machinery and unraveling target independent effect of siRNA.
Zhong, R*., Kim, J.*, Kim, H.S., Kim, M., Lum, L., Levine, B., Xiao, G., White, M.A., and Xie, Y. (2014). Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens. Nucleic acids research , DOI: 10.1093/nar/gku306 . *Joint First Authours
Kim H, Mendiratta S, Kim J, Pecot C, Larsen J, Zubovych I, Seo B, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs J, Wei S, Peyton M, Williams N, Gazdar A, Posner B, Brekken R, Sood A, Deberardinis R, Roth M, Minna M, and White M. A. (2013). Systematic identification of molecular subtype-selective vulnerabilities in non small cell lung cancer. Cell 155: 552-66.
Min J., Choi E.S., Hwang K., Kim J., Sampath S., Venkitaraman A.R., Lee H. (2012), “The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis," J Biol Chem, 287(7):5091-101.
Choi E., Choe H., Min J., Choi J.Y., Kim J., Lee H. (2009), “BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis," EMBO J, 28(14), 1991-3.
Elizabeth McMillan – Cell Regulation with Supplemental Curricula in Computational, Systems Biology
Education: B.A. – Biology, B.A. – Mathematics, 2011, New York University College of Arts and Sciences/New York University Courant Institute of Mathematical Sciences
Research Interests: Oncogenic lesions arising during cancer progression provide an attractive target for chemical intervention strategies. The extreme molecular heterogeneity of tumors, however, makes it difficult to identify authentic intervention targets and to link patients to the most appropriate treatment. To confront this challenge, we launched a full scale investigation to identify the genetic lesions that arise during cancer progression together with a computational approach to link novel compounds to these lesions. A panel of 103 non-small cell lung cancer cell lines was screened with over 200,000 uncharacterized synthetic chemical compounds and natural products fractions in a tiered HTS approach. Statistical and machine learning procedures were then used to link drug activity to the complexity of cancer genomes by systematically assigning enrollment biomarkers to each compound from measures of gene expression, gene mutation, gene copy number, protein expression, and metabolomics datasets. Using this approach, we have found that genetic vulnerabilities that are not currently actionable can be linked to novel chemicals. Experimental mechanism of action hypotheses can be derived from these chemical/biomarker relationships and were validated for a subset. Notably, we are able to parse KRAS mutant cancers into multiple, distinct molecular subtypes defined by co-occurring mutations. This indicates that KRAS lung cancers are representative of diverse mechanistic subtypes, and we are able to identify putative novel compounds that may target each subtype. Collectively, we are using this approach as a data driven way to parse mechanistic cancer subtypes and identify a diverse cohort of therapies capable of contending with cancer heterogeneity together with enrollment biomarkers that can specify sensitivity.
Ekas, L. A., T. J. Cardozo, M. S. Flaherty, E. A. McMillan, F. C. Gonsalves and E. A. Bach (2010). "Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila." Dev Biol 344(2): 621-636.
Kim, H. S., S. Mendiratta, J. Kim, C. V. Pecot, J. E. Larsen, I. Zubovych, B. Y. Seo, J. Kim, B. Eskiocak, H. Chung, E. McMillan, S. Wu, J. De Brabander, K. Komurov, J. E. Toombs, S. Wei, M. Peyton, N. Williams, A. F. Gazdar, B. A. Posner, R. A. Brekken, A. K. Sood, R. J. Deberardinis, M. G. Roth, J. D. Minna and M. A. White (2013). "Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer." Cell 155(3): 552-566.
Osborne, J. K., M. L. Guerra, J. X. Gonzales, E. A. McMillan, J. D. Minna and M. H. Cobb (2014). "NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas." Mol Biol Cell 25(11): 1782-1792
Borkowski, R., Du, L., Zhao, Z., McMillan, E., Kosti, A., Yang, C., Suraokar, M., Wistuba, I., Gazdar, A., Minna, J., White, M.A.* and Pertsemlidis, A.*. 2014. Genetic mutation of p53 and suppression of the miR17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling. Cancer Research in press. *co-corresponding authors.
Witkiewicz, A.K., McMillan, E.A., Balaji, U., Baek, H., Lin, W., Mansour, J., Mollaee, M., Wagner, K., Koduru, P., Yopp, A., Choti, M., Yeo, C.J., McCue, P., White, M.A., and Knudsen, E.S. 2015. Whole exome sequencing of pancreatic ductal adenocarcinoma reveals hallmarks of disease etiology, prognosis, and targets for therapeutic intervention. Nature Communications 6:6744.
Potts, M.B., McMillan, E.A., Rosales, T. I., Kim, H.S., Ou, Y.H., Tooms, J.E., Brekken, R.A., Minden, M.D., MacMillan, J.B., and White, M.A. 2015. Exceptional responders to dedemnin B illuminate the mechanism of action and pharmacogenomics biomarkers for antineoplastic activity. Nature Chemical Biology
McNamara, R.P., Reeder, J.E., McMillan, E.A., Bacon, C.W., McCann, J.L., and D’Orso, I.D. KAP1 recruitment of the 7SK snRNP complex to promoters enables transcription elongation by RNA Polymerase II. (2015) Molecular Cell (in press)
Shields, B.B., Pecot, C.V., Gao, H., McMillan, E., Potts, M., Nagel, C., Purinton, S., Wang, Y., Ivan, C., Kim, H.S., Borkowski, R. J., Khan, S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Lea, J., Gazdar, A., Baggerly, K.A. Sood, A.K., and White, M.A. 2015. A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Molecular Systems Biology, 11: 842.
Young, J. H., Peyton, M., Kim, H., McMillan, E., Minna, J. D., White, M. A., and Marcotte, E. M. 2016. Computational discovery of pathway-level genetic vulnerabilities in non-small-cell lung cancer. Bioinformatics, in press.
Hensley, C.T., Yuan, Q.Y., Lev-Cohain, H., Kim, J., Liang, L., Eunsook, J., Skelton, R., Loudat, L., Wodzak, M., Cai, L., Klimko, C., McMillan, E.A., Butt, Y., Torrealba, J., Malloy, C., Kernstine, K., Leninski, R.E., and Deberardinis, R.J., (2015). “Heterogeneous glucose metabolism within and between human non-small cell lung tumors”. Cell (in press)
Chensu Wang – Biomedical Engineering
Education: B.S. – Biomedical Engineering, 2011, Southeast University, Nanjing, China
Research Interests: The interface between engineering and biology; in particular the design and development of nanotechnology tools that illuminate dynamic cell biological processes in space and time. My current project is the application of novel pH-responsive nanoprobes for analysis of autophagosome biogenesis at single organelle resolution. (Joint student with Professor Jinming Gao)
Aubhishek Zaman– Cancer Biology
Education: M.S. – Genetic Engineering and Biotechnology, University of Dhaka, Bangladesh
Research Interests: Cancer therapeutics and its mode of actions; key players in cellular growth, vesicular traffic and cellular responses to nutrient availability,.
Zaman A* and Razzaque S ‘Designing Novel Antibacterials: Application of Omics Science’ Klimik Dergisi. 2013; 26; 2-8
Islam MR, Zaman A, Jahan I, Chakravorty R, Chakraborty S*. ‘In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer's disease.’J Young Pharm. 2013 Dec;5(4):173-9.
Islam MR*, Hosen MI, Zaman A, Islam MO. ‘Structural, functional and molecular docking study to characterize GMI1 from Arabidopsis thaliana.’ Interdiscip Sci. 2013 Mar;5(1):13-22.
Zaman A*, Rahaman MH, Razzaque S. ‘Kaposi's sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis.’ Virus Genes. 2013 Apr;46(2):242-54. doi: 10.1007/s11262-012-0865-z. Epub 2012 Dec 25.
Zaman A*, Fancy NN. ‘A computational prediction of structure and function of novel homologue of Arabidopsis thaliana Vps51/Vps67 subunit in Corchorus olitorius.’ Interdiscip Sci. 2012 Dec;4(4):256-67.
Zaman A*. ‘Docking studies and network analyses reveal capacity of compounds from Kandelia rheedii to strengthen cellular immunity by interacting with host proteins during tuberculosis infection.’ Bioinformation. 2012;8(21):1012-20.
Islam R, Sakib M S, and Zaman A* ‘A Computational Assay to Design an Epitope-based Peptide Vaccine against Chikungunya Virus.’ Future Virology. 2012; 7 (10):1029–1042.
Zaman A* (2012) ‘Characterization of Coilin protein nucleotide binding region in Homo sapiens’ Online Journal of Bioinformatics, 13(2):314-330.
Zaman A* ‘Drug Designing Approaches Using In-Silico Techniques’ Lambert Academic Press (LAP). 2012; ISBN: 978-3-659-15283-2
Martin Dietrich, M.D., Ph.D. - Cancer Biology
Education: M.D. – Medicine 2006, University of Heidelberg; Ph.D. – Genetics 2006, University of Heidelberg; Ph.D. – Molecular Biology 2010, UT Southwestern
Research Interest: My research interest is in the field of personalized approaches for lung cancer. The identification of ALK rearrangements and EGFR mutations changed the landscape for a subset of patients. However, the vast majority of lung cancer patient still does not benefit from this progress and undergo conventional chemotherapy. Like a fingerprint, each lung cancer provides its own unique signature of molecular changes. My work at the bench and in clinic focuses on identifying and exploiting genetic vulnerabilities of thoracic malignancies, in particular cancers of the lung. Currently, most clinical trials that substantiate our clinical treatment are a “one size fits all” approach, with little understanding about which patients will actually benefit from chemotherapy treatment. My greater goal is to understand the individual tumor biology, taking into account genetic, epigenetic and metabolic changes, and providing patients with personalized treatment strategies.
Kidd S, Spaeth E, Dembinski JL, Dietrich M, Watson K, Klopp A, et al. Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells. 2009 Oct;27(10):2614-23.
Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, et al. Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood. 2008 Apr 1;111(7):3742-50.
Ling X, Konopleva M, Zeng Z, Ruvolo V, Stephens LC, Schober W, et al. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer Res. 2007 May 1;67(9):4210-8.
Ling X, Wang Y, Dietrich MF, Andreeff M, Arlinghaus RB. Vaccination with leukemia cells expressing cell-surface-associated GM-CSF blocks leukemia induction in immunocompetent mice. Oncogene. 2006 Jul 27;25(32):4483-90.
Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.
Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, et al. Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by antiinflammatory treatment. Cytotherapy. Sep;12(5):615-25.
Dietrich MF, Karner CM, Johnson EB, Kappesser N, Tennert C, Percin F, et al. Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome. PLoS One.5(4):e10418.
Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J, Adams DJ. Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS One.5(4):e9960.
Dieckmann M, Dietrich MF, Herz J. Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family. Biol Chem. Nov;391(11):1341-63
Rachel Vaden, Ph.D. – Chemistry
Education: B.S. – Chemistry, 2008, University of West Georgia; PhD – Chemistry, 2015, University of Utah
Research interest: The use of molecular tools to probe biological systems can provide insight into complex cellular processes and disease states. My research is focused on understanding how genetic mutations acquired during tumor progression can confer sensitivity to novel bioactive compounds. Not only can these studies facilitate clinical therapeutic development by identifying patient populations that are likely to be sensitive a specific treatment, but they can also provide direct mechanistic information about cancer signaling pathways that may be used to inform additional treatment design strategies.
Vaden RM, Gligorich KM, Jana R, Sigman MS, & Welm BE (2014) The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress. Breast Cancer Res 16(6):472.
Gligorich KM*, Vaden RM*, Shelton DN, Wang G, Matsen CB, Looper RE, Sigman, MS, & Welm BE (2013) Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells. Breast Cancer Res 15(4):R58.
Pathak TP, Osiak JG, Vaden RM, Welm BE, Sigman MS (2012) Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles. Tetrahedron 68(26):5203.
Caroline Diep, Ph.D. – Cancer Biology
Education: B.A. – Art History 2003, University of Arizona; B.S. – Molecular Cellular Biology 2005, University of Arizona; Ph.D. – Microbiology, Immunology, and Cancer Biology 2015, University of Minnesota.
Research interest: I am interested in identifying and understanding the master molecular drivers and/or regulators of squamous lung carcinoma biology. Insights gained will be leveraged into novel and efficacious therapeutic strategies to precisely treat tumors.
Diep CH, Knutson TP, Lange CA. Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Mol Cancer Res. Nov 17, 2015. PMID: 26577046
Whatcott CJ, Diep CH, Jiang P, Watanabe A, Lobello J, Sima C, Hostetter G, Shepard M, Von Hoff DD, Han H. Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer. Clin Cancer Res. 2015 Aug 1;21(15):3561-8. PMID: 25695692
Diep CH, Daniel AR, Mauro LJ, Knutson TP, Lange CA. Progesterone action in breast, uterine, and ovarian cancers. J Mol Endocrinol. 2015; 54(2):R31-53. PMID: 25587053
Dressing GE, Knutson TP, Schiewer MJ, Daniel AR, Hagan CR, Diep CH, Knudsen KE, Lange CA. Progesterone receptor-cyclin D1 complexes induce cell cycle-dependent transcriptional programs in breast cancer cells. Mol Endocrinol. 2014; 28(4):442-57. PMID: 24606123
Diep CH, Charles NJ, Gilks CB, Kalloger SE, Argenta PA, Lange CA. Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle. 2013; 12(9):1433-49. PMID: 23574718
Diep CH, Zucker K, Hostetter G, Watanabe A, Hu C, Munoz RM, Von Hoff DD, Han H. Down-regulation of Yes-Associated Protein 1 (YAP1) expression reduces cell proliferation and clonogenicity of pancreatic cancer cells. PLoS One. 2012; 7(3):e32783. PMID: 22396793
Diep CH, Munoz RM, Choudhary A, Von Hoff DD, Han H. Synergistic effect between erlotinib and MEK inhibitors in K-Ras wildtype human pancreatic cancer cells. Clin Cancer Res. 2011; 17(9):2744-56. PMID: 21385921
Jeon Lee, Ph.D. – Computational Biology
Education: Ph.D. – Biomedical Engineering, 2006, Yonsei University, South Korea; Postdoctoral Fellow, 2013-2014, Johns Hopkins University School of Medicine
Research Interests: Data fusion for anti-cancer drug response prediction, machine learning algorithms for cancer biology and biomedical image and signals, physiological signal analytics, arrhythmia diagnosis and prognosis algorithms, finding links between sleep apnea and arrhythmia, scientific approaches to traditional Korean/Chinese medicine, and clinical trials.
Lee, C. H, Park, K. H, Nam, J. H, Lee, J., Choi, Y. J., Kong, E. J. Son, J. W., Kim, U., Park, J. S., Kim, Y. J., and Shin, D. G (2015). Increased Variability of the Coupling Interval of Premature Ventricular Contractions as a Predictor of Cardiac Mortality in Patients with Left Ventricular Dysfunction. Circulation Journal, 79(11), 2360-2366.
Lee, J., Kim, S. J., Chen, R., and Herskovits, E. H. (2015, August). Brain tumor image segmentation using kernel dictionary learning. In Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE (pp. 658-661). IEEE.
Kim, J. U., Lee, Y. J., Lee, J., and Kim, J. Y. (2015). Differences in the Properties of the Radial Artery between Cun, Guan, Chi, and Nearby Segments Using Ultrasonographic Imaging: A Pilot Study on Arterial Depth, Diameter, and Blood Flow. Evidence-Based Complementary and Alternative Medicine.
Lee, J., & Finkelstein, J. (2014). Evaluation of a portable stress management device. Studies in health technology and informatics, 208, 248-252.
Lee, J., and Finkelstein, J. (2014). Consumer sleep tracking devices: a critical review. Studies in health technology and informatics, 210, 458-460.
Choi, Y. J., Park, K. H., Lee, C. H., Lee, S. H., Park, J. S., Kim, U., Son, J. W., Lee, J., Kim, J. R., and Shin, D. G. (2014). “Optimal” cutoff value of heart rate; appraisal based on heart rate variability and C-reactive protein. International journal of cardiology, 176(2), 497-499.
Lee, H. K., Lee, J., Kim, H., Ha, J. Y., and Lee, K. J. (2013). Snoring detection using a piezo snoring sensor based on hidden Markov models. Physiological measurement, 34(5), N41.
Lee, J., Song, M. H., Shin, D. G., and Lee, K. J. (2012). Event synchronous adaptive filter based atrial activity estimation in single-lead atrial fibrillation electrocardiograms. Medical & biological engineering & computing, 50(8), 801-811.
Kiran Kaur, Ph.D. – Adjunct Instructor / Lab Manager
Education: M.S., 1982, University of Kentucky; Ph.D. 1994, Southern Methodist University
Saurabh Mendiratta – Research Scientist
Education: M.S. – Biotechnology, 2003, MS University, Baroda, India; M.S. – Cell and Molecular Biology, 2006, University of Texas at Dallas
Research Interests: High throughput SiRNA and chemical compound screening to identify gene targets selectively required for cancer cell survival.
Kim, H. S., Mendiratta S., J. Kim, C. V. Pecot, J. E. Larsen, I. Zubovych, B. Y. Seo, J. Kim, B. Eskiocak, H. Chung, E. McMillan, S. Wu, J. De Brabander, K. Komurov, J. E. Toombs, S. Wei, M. Peyton, N. Williams, A. F. Gazdar, B. A. Posner, R. A. Brekken, A. K. Sood, R. J. Deberardinis, M. G. Roth, J. D. Minna and M. A. White (2013). "Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer." Cell 155(3): 552-566.
Potts, M.B., Kim, H.S., Fisher, K.W., Hu, Y., Carrasco, Y., Bulut, G.B., Ou, Y.-H., Herrera-Herrera, M.L., Cubillos, F., Mendiratta, S., Xiao, G., Hofree, M., Ideker, T., Xie, Y., Huang, L.J.-S., Lewis, R.E., MacMillan, J.B., and White, M.A. (2013). Using Functional Signature Ontology (FUSION) to identify mechanisms of action for natural products. Sci. Signal., 6(297), ra90.
Ward S.E., Kim H.S., Komurov K. Mendiratta S., Tsai P.L, Schmolke M., Satterly N., Manicassamy B., Forst C.V., Roth M.G., García-Sastre A., Blazewska K.M., McKenna C.E., Fontoura B.M., White M.A., "Host Modulators of H1N1 Cytopathogenicity," PLoS One, 2012;7(8):e39284. Epub 2012 Aug 2.
Goldsmith E.J., Mendiratta S., Akella R., Dahlgren K., "Natural language query in the biochemistry and molecular biology domains based on cognition search™," Summit on Translat Bioinforma, 2009 Mar 1;2009:32-7.
Garcia-Rodriguez J., Mendiratta, S., White, M. A., Xie, X.-S., and De Brabander, J. K. 2015. Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs. Bioorganic and Medical Chemistry Letters, 25:4393-4398.
Li, Y., Mendiratta, S., Ehrhardt, K., Kashyap, N., White, M. A., Bleris, L. 2015. Exploiting the CRSPR/Cas9 PAM constraint for single-nucleotide resolution interventions. Plos One, 11:e0144970.
Jean René Clemenceau - Research Assistant I
Education: B.S. - Informatics, 2013, Baylor University
Role: I am the administrator for the lab's databases and servers. I also develop and mantain the lab's different software tools. These include web user interfaces used to access and analyze the data produced and gathered by the lab and fellow contributors within our different projects. I strive to create user-friendly tools that can increase the efficiency of drug discovery out of massive amounts of data.
Gurbani Makkar - Research Technician II
Education: B.S. - Neuroscience, 2015, University of Texas at Dallas
Michael A. White, Ph.D. – Professor, Cell Biology
Grant A. Dove Chair for Research in Oncology
The Sherry Wigley Crow Cancer Research Endowed Chair in Honor of Robert Lewis Kirby, M.D.
Education: University of Iowa (1986), Undergraduate; University of North Carolina at Chapel Hill (1992), Graduate
Research Interests: Cancer, molecular architecture of growth regulatory signal transduction cascades, oncogenes, signal transduction and tumor suppressors
Publications: 1992 – 2015