Ken Westover Lab

Targeted Therapy for Cancer

We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.

Drugging RAS

Drug hunters struggled for decades to target RAS. We were among the first to develop irreversible KRAS G12C inhibitors.

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RAS Structure

RAS mutations are found in many malignant tumors, but not all RAS mutations work alike. We study how mutations impact RAS protein dynamics.

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Drugging Kinases

Protein kinase inhibitors are a major class of targeted therapies, especially for cancer. We are working to expand the arsenal of kinase inhibitors.

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