Dr. Yingfei Wang obtained her Ph.D. degree in neuroscience at the University of Magdeburg in Germany and completed her postdoctoral training at the Johns Hopkins School of Medicine. In December 2014, Dr. Wang became an assistant professor in the Department of Pathology and Neurology at UT Southwestern.
Dr. Wang studies the molecular and cellular mechanisms of neuronal cell death in neurologic diseases. The nuclear enzyme poly(ADP-ribose) polymerase- 1 (PARP-1) plays an important role in cell death through a caspase-independent manner after ischemia-reperfusion injury, glutamate excitotoxicity and various inflammatory responses, as well as neurodegenerative diseases.
Dr. Wang uses a combination of tools, including epigenetics, bioinformatics, proteomics and mouse genetics, to study the cell signaling and regulation of PARP-1 dependent DNA damage and cell death in stroke and other neurologic diseases. Her overall goals are to identify novel therapeutic targets and translate the knowledge to develop therapeutic strategies to prevent or treat neurologic diseases.