Publications

Publications for Edward K. Wakeland, Ph.D.

Recent Publications (from more than 170 journals)

2014

1: Sinai P, Dozmorov IM, Song R, Schwartzberg PL, Wakeland EK, Wülfing C. "T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice." Eur J Immunol. 2014 Dec;44(12):3522-31. doi: 10.1002/eji.201444602. Epub 2014 Nov 12. PubMed PMID: 25209945.

2: Zhao H, Li Y, Wang S, Yang Y, Wang J, Ruan X, Yang Y, Cai K, Zhang B, Cui P, Yan J, Zhao Y,Wakeland EK, Li Q, Hu S, Fang X. "Whole transcriptome RNA-seq analysis: tumorigenesis and metastasis of melanoma." Gene. 2014 Sep 15;548(2):234-43. doi: 10.1016/j.gene.2014.07.038. Epub 2014 Jul 15. PubMed PMID: 25034661.

3: Wakeland EK. "Hunting autoimmune disease genes in NOD: early steps on a long road to somewhere important (hopefully)." J Immunol. 2014 Jul 1;193(1):3-6. doi: 10.4049/jimmunol.1401200. PubMed PMID: 24951821.

4: Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcón-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. "Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription." Am J Hum Genet. 2014 Apr 3;94(4):586-98. doi: 10.1016/j.ajhg.2014.03.008. PubMed PMID: 24702955.

5: Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sánchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M; GENLES, Looger LL, Nath SK. "Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations." Hum Mol Genet. 2014 Mar 15;23(6):1656-68. doi: 10.1093/hmg/ddt532. Epub 2013 Oct 26. PubMed PMID: 24163247.

2013

1: Yang Y, Wang H, Chang KH, Qu H, Zhang Z, Xiong Q, Qi H, Cui P, Lin Q, Ruan X, Yang Y, Li Y, Shu C, Li Q, Wakeland EK, Yan J, Hu S, Fang X. "Transcriptome dynamics during human erythroid differentiation and development." Genomics 2013 Oct 8. doi:pii: S0888-7543(13)00186-9. 10.1016/j.ygeno.2013.09.005. [Epub ahead of print] PubMed PMID: 24121002.

2: Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS. "SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature." PLoS One 2013 Jun 24;8(6):e67003. doi: 10.1371/journal.pone.0067003. Print 2013. PubMed PMID: 23826184; PubMed Central PMCID: PMC3691135.

3: Zhu L, Yan Z, Zhang Z, Zhou Q, Zhou J, Wakeland EK, Fang X, Xuan Z, Shen D, Li QZ. "Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements." PLoS One 2013 Jun 24;8(6):e66584. doi: 10.1371/journal.pone.0066584. Print 2013. PubMed PMID: 23826102; PubMed Central PMCID: PMC3691203.    

4: Wang H, Hu H, Zhang Q, Yang Y, Li Y, Hu Y, Ruan X, Yang Y, Zhang Z, Shu C, Yan J, Wakeland EK, Li Q, Hu S, Fang X. "Dynamic transcriptomes of human myeloid leukemia cells." Genomics 2013 Jun 24. doi:pii: S0888-7543(13)00125-0. 10.1016/j.ygeno.2013.06.004. [Epub ahead of print] PubMed PMID: 23806289.    

5: Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rosé CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P; Boston Children's JIA Registry; British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group; Childhood Arthritis Prospective Study (CAPS); Childhood Arthritis Response to Medication Study (CHARMS); German Society for Pediatric Rheumatology (GKJR); JIA Gene Expression Study; NIAMS JIA Genetic Registry; TREAT Study; United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC), Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD. "Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis." Nat Genet 2013 Jun;45(6):664-9. doi: 10.1038/ng.2614. Epub 2013 Apr 21. PubMed PMID: 23603761; PubMed Central PMCID: PMC3673707.    

6: Su RJ, Yang Y, Neises A, Payne KJ, Wang J, Viswanathan K, Wakeland EK, Fang X, Zhang XB. "Few single nucleotide variations in exomes of human cord blood induced pluripotent stem cells." PLoS One 2013;8(4):e59908. doi: 10.1371/journal.pone.0059908. Epub 2013 Apr 1. PubMed PMID: 23573220; PubMed Central PMCID: PMC3613421.    

7: Arai S, Maehara N, Iwamura Y, Honda S, Nakashima K, Kai T, Ogishi M, Morita K, Kurokawa J, Mori M, Motoi Y, Miyake K, Matsuhashi N, Yamamura K, Ohara O, Shibuya A, Wakeland EK, Li QZ, Miyazaki T. "Obesity-associated autoantibody production requires AIM to retain the immunoglobulin M immune complex on follicular dendritic cells." Cell Rep 2013 Apr 25;3(4):1187-98. doi: 10.1016/j.celrep.2013.03.006. Epub 2013 Apr 4. PubMed PMID: 23562157.

8: Dutta M, Kraus ZJ, Gomez-Rodriguez J, Hwang SH, Cannons JL, Cheng J, Lee SY, Wiest DL, Wakeland EK, Schwartzberg PL. "A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes." J Immunol 2013 Mar 1;190(5):2121-8. doi: 10.4049/jimmunol.1202145. Epub 2013 Jan 25. PubMed PMID: 23355739; PubMed Central PMCID: PMC3578000.

9: Shao X, Yang R, Yan M, Li Y, Du Y, Raman I, Zhang B, Wakeland EK, Igarashi P, Mohan C, Li QZ. "Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis." Arthritis Rheum 2013 Mar;65(3):780-91. doi: 10.1002/art.37798. Erratum in: Arthritis Rheum. 2013 Apr; 65(4):1106. Wakeland, Ward [corrected to Wakeland, Edward K]. PubMed PMID: 23280471.

10: Yang Y, Wang H, Chang KH, Qu H, Zhang Z, Xiong Q, Qi H, Cui P, Lin Q, Ruan X, Yang Y, Li Y, Shu C, Li Q, Wakeland EK, Yan J, Hu S, Fang X. "Transcriptome dynamics during human erythroid differentiation and development." Genomics. 2013 Nov-Dec;102(5-6):431-41. doi: 10.1016/j.ygeno.2013.09.005. Epub 2013 Oct 8. PubMed PMID: 24121002.

11: Becker AM, Dao KH, Han BK, Kornu R, Lakhanpal S, Mobley AB, Li QZ, Lian Y, Wu T, Reimold AM, Olsen NJ, Karp DR, Chowdhury FZ, Farrar JD, Satterthwaite AB, Mohan C, Lipsky PE, Wakeland EK, Davis LS. "SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature." PLoS One. 2013 Jun 24;8(6):e67003. doi: 10.1371/journal.pone.0067003. Print 2013. PubMed PMID: 23826184.

12: Zhu L, Yan Z, Zhang Z, Zhou Q, Zhou J, Wakeland EK, Fang X, Xuan Z, Shen D, Li QZ. "Complete genome analysis of three Acinetobacter baumannii clinical isolates in China for insight into the diversification of drug resistance elements." PLoS One. 2013 Jun 24;8(6):e66584. doi: 10.1371/journal.pone.0066584. Print 2013. 475. Epub 2012 Nov 18. PubMed PMID: 23826102.

2012

10: Ozaltin F, Li B, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang C, Chen P, Lu D, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M. "DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN." J Am Soc Nephrol. 2013 Feb;24(3):377-84. doi: 10.1681/ASN.2012090903. Epub 2012 Dec 28. PubMed PMID: 23274426; PubMed Central PMCID: PMC3582208.    

11: Li Y, Wang H, Yang B, Yang J, Ruan X, Yang Y, Wakeland EK, Li Q, Fang X. "Influence of carbon monoxide on growth and apoptosis of human umbilical artery smooth muscle cells and vein endothelial cells." Int J Biol Sci. 2012;8(10):1431-46. doi: 10.7150/ijbs.4664. Epub 2012 Nov 17. PubMed PMID: 23197940; PubMed Central PMCID: PMC3509336.    

12: Hasan M, Koch J, Rakheja D, Pattnaik AK, Brugarolas J, Dozmorov I, Levine B, Wakeland EK, Lee-Kirsch MA, Yan N. "Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes." Nat Immunol. 2013 Jan;14(1):61-71. doi: 10.1038/ni.2475. Epub 2012 Nov 18. PubMed PMID: 23160154; PubMed Central PMCID: PMC3522772.    

13: Hwang SH, Lee H, Yamamoto M, Jones LA, Dayalan J, Hopkins R, Zhou XJ, Yarovinsky F, Connolly JE, Curotto de Lafaille MA, Wakeland EK, Fairhurst AM. "B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice." J Immunol. 2012 Dec 15;189(12):5786-96. doi: 10.4049/jimmunol.1202195. Epub 2012 Nov 12. PubMed PMID: 23150717; PubMed Central PMCID: PMC3544945.    

14: Kaiser R, Taylor KE, Deng Y, Zhao J, Li Y, Nititham J, Chang M, Catanese J, Begovich AB, Brown EE, Edberg JC, McGwin G, Alarcón GS, Ramsey-Goldman R, Reveille JD, Vila LM, Petri M, Kimberly RP, Feng X, Sun L, Shen N, Li W, Lu JX, Wakeland EK, Li QZ, Yang W, Lau YL, Liu FL, Chang DM, Yu CY, Song YW, Tsao BP, Criswell LA; Hwee Siew Howe and the Tan Tock Seng Hospital Systemic Lupus Erythematosus Study Group. "Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians." Arthritis Rheum. 2013 Jan;65(1):211-5. doi: 10.1002/art.37751. PubMed PMID: 23124848; PubMed Central PMCID: PMC3670944.    

15: Crow YJ, Wakeland EK. "Autoimmunity." Curr Opin Immunol. 2012 Dec; 24(6):649-50. doi: 10.1016/j.coi.2012.10.007. Epub 2012 Nov 2. PubMed PMID: 23123279.

16: Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martín J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. "Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus." Arthritis Rheum. 2012 Nov;64(11):3695-705. doi: 10.1002/art.34642. PubMed PMID: 22833143; PubMed Central PMCID: PMC3485412.

17: Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. "A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus." Genes Immun. 2012 Jul;13(5):380-7. doi: 10.1038/gene.2012.6. Epub 2012 Apr 5. PubMed PMID: 22476155; PubMed Central PMCID: PMC3411915.    

18: Namjou B, Keddache M, Fletcher D, Dillon S, Kottyan L, Wiley G, Gaffney PM, Wakeland BE, Liang C, Wakeland EK, Scofield RH, Kaufman K, Harley JB. "Identification of novel coding mutation in C1qA gene in an African-American pedigree with lupus and C1q deficiency." Lupus. 2012 Sep;21(10):1113-8. doi: 10.1177/0961203312443993. Epub 2012 Apr 3. PubMed PMID: 22472776; PubMed Central PMCID: PMC3508769.    

19: Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, Alarcón-Riquelme ME, Alarcón GS, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Cho SK, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Kim JH, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Scofield RH, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Kaufman KM, Harley JB, Wakeland EK, Langefeld CD, Gaffney PM, Montgomery CG, Moser KL; BIOLUPUS Network; GENLES Network. "Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study." Am J Hum Genet. 2012 Apr 6;90(4):648-60. doi: 10.1016/j.ajhg.2012.02.023. Epub 2012 Mar 29. PubMed PMID: 22464253; PubMed Central PMCID: PMC3322228.    

2011

20: Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV. "The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine." Science 2011 Oct 14;334(6053):255-8. doi: 10.1126/science.1209791. PubMed PMID: 21998396; PubMed Central PMCID: PMC3321924.

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