Research

Natural Product Synthesis

To complement our discovery of new metal-catalyzed rearrangements, we are also developing selective methods for the assembly of biologically active polycyclic alkaloids. As part of our natural product synthesis program, we recently completed a total synthesis of trigonoliimine C via a selective oxidative rearrangement of a conjugated tryptamine heterodimer. We have also developed stereoselective routes to other natural product families, including the amathaspiramides.