Publications for Dr. Xiankai Sun

Peer-Reviewed Publications (since 2005)

  1. Sun X, Fang H, Li X, Rossin R, Welch MJ, and Taylor J-S: MicroPET Imaging of MCF-7 Tumors in Mice via unr mRNA-targeted Peptide Nucleic Acids. Bioconjugate Chem., 2005, 16, 294-305.
  2. Rossin R., Pan D., Qi K., Turner JL, Sun X, Wooley KL, and Welch MJ: 64Cu-labeled folate-conjugated shell cross-linked nanoparticles for tumor imaging and radiotherapy: Synthesis, radiolabeling and biological evaluation. Nucl. Med. 2005, 46, 1210-1218.
  3. Sun X, Rossin R, Turner JL, Becker ML, Joralemon MJ, Welch MJ, and Wooley KL: An Assessment of the Effects of Shell Cross-Linked Nanoparticle Size, Core Composition, and Surface PEGylation on in Vivo Biodistribution. Biomacromolecules 2005, 6(5), 2541-2554.
  4. Ruangma A, Bai B, Lewis JS, Sun X, Welch MJ, Leahy R, Laforest R: Three-dimensional Maximum a Posteriori (MAP) Imaging with Radiopharmaceuticals Labeled with Three Cu Radionuclides. Med. Biol. 2006, 33, 217-226.
  5. Chong H-S, Mhaske S, Lin M, Bhuniya S, Song HA, and Sun X: Novel bimodal ligands of 64Cu for targeted PET imaging and radiotherapy. Med. Chem. Lett., 2007, 17(22), 6107-6110.
  6. Fan J, Stanfield J, Guo Y, Karam JA, Frenkel E, Sun X, and Hsieh J-T: Effect of trans-2, 3-dimethoxycinnamoyl azide (DMCA) on enhancing anti-tumor activity of Romidepsin on human bladder cancer. Clinical Cancer Research, 2008, 14(4), 1200-1207
  7. Vasalatiy O, Gerard R, Zhao P, Sun X, and Sherry AD: Labeling of Adenovirus Particles with PARACEST Agents. Bioconjugate Chem., 2008, 19(3), 598-606
  8. Kalman FK, Baranyai Z, Toth I, Banyai I, Kiraly R, Bruecher E, Aime S, Sun X, Sherry AD, and Kovacs Z: Synthesis, Potentiometric, Kinetic, and NMR Studies of 1,4,7,10-Tetraazacyclododecane-1,7-bis(acetic acid)-4,10-bis(methylenephosphonic acid) (DO2A2P) and its Complexes with Ca(II), Cu(II), Zn(II) and Lanthanide(III) Ions. Chem., 2008, 47(9), 3851-3862
  9. Lim J, Guo Y, Rostollan CL, Stanfield J, Hsieh J-T, Sun X*, and Simanek EE*: Biodistribution and Tumor Localization of Triazine Dendrimers. Pharm., 2008, 5(4), 540-547.
  10. Liu W, Hajibeigi A, Lin M, Rostollan CL, Kovacs Z, Öz OK, and Sun X: An osteoclast-targeting agent for imaging and therapy of bone metastasis. Med. Chem. Lett., 2008, 18, 4789-4793.
  11. Woods M, Caravan P, Geraldes CFGC, Greenfield MT, Kiefer GE, Lin M, McMillan K, Prata MIM, Santos AC, Sun X, Wang J, Zhang S, Zhao P, and A. Dean Sherry AD: The Effect of the Amide Substituent on the Biodistribution and Tolerance of Lanthanide(III) DOTA-Tetraamide Derivatives. Radiol. 2008, 43(12), 861-870
  12. Zhou Y, Gulaka P, Zhou J, Xiao M, Xu D, Hsieh J-T, Kodibagkar V, and Sun X: Preparation and Evaluation of a Radioisotope-incorporated Iron Oxide Core/Au Shell Nanoplatform for Dual Modality Imaging. Biomed. Nanotechnol. 2008, 4:474-481
  13. Pasha A, Lin M, Tircsó G, Woods M, Garry E. Kiefer GE, Sherry AD, and Sun X: Synthesis and biological evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups. Biol. Inorg. Chem. 2009, 14(3), 421-438
  14. Li S, McGuire MJ, Lin M, Liu Y-H, Oyama T, Sun X, and Brown KC: Synthesis and Characterization of a High Affinity αvβ6-Specific Ligand for In Vitro and In Vivo Applications. Mol Cancer Ther. 2009, 8(5), 1239-1249
  15. Liu J, Hajibeigi A, Ren G, Lin M, Siyambalapitiyage W, Liu Z, Simpson E, Parkey RW, Sun X, and Oz OK: Retention of the radiotracers 64Cu-ATSM and 64Cu-PTSM in human and murine tumors is influenced by MDR1 protein expression. Nucl. Med. 2009, 50(8), 1332-1339.
  16. Liu W, Hao G, Long LA, Anthony T, Hsieh J-T, and Sun X: Imparting Multivalency to a Bifunctional Chelator: A Scaffold Design for Targeted PET Imaging Probes. Chem. Int. Ed., 2009, 48(40): 7346-7349
  17. Lim J, Abdellatif Chouai A, Su-Tang Lo S-T, Liu W, Sun X, and Simanek EE: Design, Synthesis, Characterization, and Biodistribution of Triazine Dendrimers Bearing Paclitaxel linked by Ester and Ester/Disulfide Linkages. Bioconjugate Chem., 2009, 20(11), 2154-2161
  18. Xiao M, Nyagilo J, Arora V, Kulkarni P, Xu D, Sun X, Davé DP: Gold Nanotags for Combined Multi-Colored Raman Spectroscopy and X-Ray Computed Tomography. Nanotechnology, 2010, 21(3): 1-8
  19. Xie D, Gore C, Liu J, Pong, RC, Mason, RP, Hao G, Long M, Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman DA, Min W, and Hsieh JT: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Natl. Acad. Sci. USA, 2010, 107(6): 2485-2490.
  20. Huang C, Hao Y, Nyagilo J, Dave, DP, Xu L, and Sun X: Porous hollow gold nanoparticles for cancer SERS imaging. Nano Res., 2010, 10: 137-148
  21. Hao G, Zhou J, Guo Y, Long MA, Anthony T, Stanfield J, Hsieh, J-T, and Sun X: A cell permeable peptide analog as a potential specific PET imaging probe for prostate cancer detection. Amino Acids. 2010, 41(5), 1093-1101
  22. Lo S-T, Stern S, Clogston JD, Zheng J, Adiseshaiah PP, Dobrovolskaia M, Lim J, Patri A*, Sun X*, and Eric E. Simanek EE*: Biological Assessment of Triazine Dendrimers as Candidate Platforms for Nanomedicine: Toxicological Profiles, Solution Behavior, Biodistribution, and Drug Release and Efficacy in a PEGylated, Paclitaxel Construct. Pharm. 2010, 7:993-1006.
  23. De Leon-Rodriguez LM, Lubag A, Udugamasooriya DG, Proneth B, Brekken RA, Sun X, Kodadek T, and Sherry AD: MRI Detection of VEGFR2 in Vivo Using a Low Molecular Weight Peptoid-(Gd)8-Dendron for Targeting. Am. Chem. Soc., 2010, 132(37):12829-12831
  24. Drerup JM, Hayashi K, Huxing Cui H, Mettlach GL, Long MA, Marvin M, Sun X, Goldberg MS, Lutter M, and Bibb JA: Attention-Deficit/Hyperactivity Phenotype in Mice Lacking the Cyclin-dependent Kinase 5 Cofactor p35. Biological Psychiatry, 2010, 68(12):1163-1171.
  25. Dence CS, Laforest R, Sun X, Sharp TL, Welch MJ, and Mach RH: Radiochemical synthesis, rodent biodistribution and tumor uptake, and dosimetry calculations of [11C]methylated LY2181308. Imaging Biol. 2010, 12:608-615.
  26. Suriamoorthy P, Zhang X, Hao G, Joly AG, Singh S, Hossu M, Sun X, and Chen W: Folic acid-CdTe quantum dot conjugates and their applications for cancer cell targeting. Cancer Nanotechnology, 2011, 1(1-6): 19-28.
  27. Zhou C, Long MA, Qin M, Sun X*, and Zheng J*: Luminescent Gold Nanoparticles with Efficient Renal Clearance. Chem. Int. Ed. 2011, 50(14), 3168-3172.
  28. Shen J, Tsai Y-T, DiMarco N, Sun X, and Tang L: Transplantation of mesenchymal stem cells from younger donors delayed osteoporosis in old mice. Scientific Reports, 2011, 1:67, doi:10.1038/srep00067
  29. Hao G, Hajibeigi A; León-Rodríguez, LMD, Öz OK*; and Sun X*: Peptoid-based PET Imaging of Vascular Endothelial Growth Factor Receptor (VEGFR) Am. J. Nucl. Med. Mol. Imaging, 2011, 1(1): 65-75 (Highlighted a dedicated Editor’s Perspective essay).
  30. Singh AN, Liu W, Hao G, Kumar A, Gupta A, Öz OK, Hsieh J-T, and Sun X: Multivalent Bifunctional Chelator Scaffolds for Gallium-68 Based Positron Emission Tomography Imaging Probe Design: Signal Amplification via Multivalency. Bioconjugate Chem. 2011, 22(8):1650-1662.
  31. Zhou J, Liu W, Pong RC , Hao G, Sun X, and Hsieh JT: Analysis of oligo‐arginine cell‐permeable peptides uptake by prostate cells. Amino Acids. 2012, 42(4):1253-1260. DOI:10.1007/s00726‐010‐0817‐7
  32. Peng F, Lutsenko S, Sun X, and Muzik O: Positron Emission Tomography of Copper Metabolism in the Atp7b−/− Knock-out Mouse Model of Wilson’s Disease. Imaging Biol. 2012, 14(1):70-8.
  33. Peng F, Lutsenko S, Sun X and Muzik O: Imaging Copper Metabolism Imbalance in Atp7b -/- Knock-out Mouse Model of Wilson’s Disease with PET-CT and Orally Administered 64CuCl2. Imaging Biol. 2012, 14(5):600-7.
  34. Marin-Valencia I, Cho SK, Mashimo T, Good LB, Jindal A, Hatanpaa KJ, Vemireddy V, Payal Kapur P, Rakheja D, Sun X, Mickey B, Pascual JM, Choi C, Takahashi M, Togao O, DeBerardinis RJ, Maher EA, Malloy CR and Bachoo RM: Glucose metabolism via the pentose phosphate pathway, glycolysis and citric acid cycle in an orthotopic mouse model of human brain tumors. NMR in Biomedicine, 2012, 25(10):1177-86
  35. Lim J, Lo ST, Hill S, Pavan GM, Sun X* and Simanek EE*: Antitumor Activity and Molecular Dynamics Simulations of Paclitaxel-Laden Triazine Dendrimers. Molecular Pharmaceutics. 2012, 9(3): 404-412
  36. Zhou C, Hao G, Thomas P, Liu J, Yu M, Sun S, Öz OK, Sun X*, and Zheng J*: Near Infrared Emitting Radioactive Gold Nanoparticles with Small-molecule-like Pharmacokinetics. Chem. Int. Ed., 2012, 51(40): 10118-10122
  37. Vasdev N, Cao P, van Oosten EM , Wilson AA, Houle S, Hao G, Sun X, Slavine N, Alhasan M, Antich PP, Bonte, FJ, and Kulkarni P: Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer’s disease. Chem. Commun., 2012, 3(10): 1228-1230. DOI:10.1039/C2MD20075A.
  38. Hao G, Sun X*, Do QN, Ocampo-Garcia B, Vilchis-Juarez A, Ferro-Flores G, De Leon-Rodriguez LM*: Cyclization of RGD peptide sequences via the macrocyclic chelator DOTA for integrin imaging. Dalton Transactions, 2012, 41(46):14051-14054.
  39. Hao G, Kumar A, Dobin T, Oz OK, Hsieh, J-T, and Sun X: A Multivalent Approach of Imaging Probe Design to Overcome an Endogenous Anion Binding Competition for Noninvasive Assessment of Prostate Specific Membrane Antigen. Molecular Pharmaceutics. 2013, 10(8): 2975-2985.
  40. Nair AM, Tsai Y-T, Shah KM, Shen J, Weng H, Zhou J, Sun X, Saxena R, Borrelli J Jr, and Tang L: The effect of erythropoietin on autologous stem cell-mediated bone regeneration. Biomaterials, 2013, 34:7364-7371.
  41. Lo S-T, Kumar A, Hsieh J-T, and Sun X: Dendrimer Nanoscaffolds for Potential Theranostics of Prostate Cancer with a Focus on Radiochemistry. Molecular Pharmaceutics 2013, 10(3):793-812. PMCID:PMC3599782
  42. Zhou J, Hao G, Weng H, Tsai Y-T, Baker DW, Sun X, and Tang L: In vivo evaluation of medical device-associated inflammation using a macrophage-specific positron emission tomography (PET) imaging probe. Med. Chem. Lett. 2013, 23(7): 2044-2047.
  43. Stafford JH, Hao G, Best AM, Sun X, and Philip Thorp: Specific PET Imaging of Prostate Tumors in Mice with an Iodine-124-Labeled Antibody Fragment that Targets Exposed Phosphatidylserine. PLoS One. 2013 Dec 19;8(12):e84864. doi: 10.1371/journal.pone.0084864.
  44. Lee C, Lo S-T, Lim J, Viviana CP, Ramezani S, Oz OK, Pavan GM, Annunziata O, Sun X, and Simanek EE: Design, Synthesis and Biological Assessment of a Triazine Dendrimer with Approximately 16 Paclitaxel Groups and 8 PEG Groups. Molecular Pharmaceutics, 2013, 10(12):4452-4461.
  45. Pozo K, Castro-Rivera E, Tan C, Plattner F, Schwach G, Siegl V, Meyer D, Guo A, Gundara J, Mettlach G, Richer E, Guevara JA, Ning L, Gupta A, Hao G, Tsai, L-H, Sun X, Antich P, Sidhu S, Robinson BG, Chen H, Nwariaku FE, Pfragner R, Richardson JA, and Bibb JA: The Role of Cdk5 in Neuroendocrine Thyroid Cancer. Cancer Cell. 2013, 24(4), 499-511.
  46. Patra S, Kozura B, Huang A Y-H, Enciso AE, Sun X, Hsieh JT, Kao C-L, Chen H-T, and Simanek EE: Dendrimers Terminated with Dichlorotriazine Groups Provide a Route to Compositional Diversity. Organic Letters, 2013, 15(15): 3808-3811.
  47. Wu K, Liu J, Tseng S-F, Gore C, Ning Z, Sharifi N, Fazli L, Gleave M, Kapur P, Xiao G, Sun X, Oz OK, Min W, Alexandrakis G, Yang C-R, Hsieh C-L, Wu H-C, He D, Xie D, and Hsieh J-T: The role of DAB2IP in androgen receptor activation during prostate cancer progression. Oncogene, 2014, 33, 1954-1963.
  48. Singh AN, Dakanali M, Hao G, Ramezani S, Kumar A,Sun X: Enantiopure bifunctional chelators for copper radiopharmaceuticals - Does chirality matter in radiotracer design? J. Med. Chem. 2014, 80, 308-315. 
  49. Swiercz R, Chiguru S, Tahmasbi A, Ramezani SM, Hao G, Challa1 DK, Lewis MA, Kulkarni PV, Sun X, Ober RJ, Mason RP and Ward ES: Use of Fc-Engineered Antibodies as Clearing Agents to Increase Contrast During PET. J Nucl Med.2014, 55:1204-
  50. Singh AN, McGuire MJ, Li S, Hao G, Kumar A, Sun X and Brown KC: Dimerization of a Phage-Display Selected Peptide for Imaging of αvβ6-Integrin: Two Approaches to the Multivalent Effect. Theranostics, 2014; 4(7): 745-760. doi: 10.7150/thno.7811
  51. Vinluan RD, Liu J, Zhou C, Yu M, Yang S, Kumar A, Sun S, Dean A, Sun X and Zheng J: Glutathione-​Coated Luminescent Gold Nanoparticles: A Surface Ligand for Minimizing Serum Protein Adsorption. ACS Applied Materials & Interfaces, 2014, 6(15), 11829-11833. 
  52. Nguyen LH, Robinson DA, Seligson, M, Wu L, Li L, Rakheja D, Comerford S, Ramezani S, Sun X, Parikh M, Yang E, Powers JT, Shinoda G, Shah S, Daley GQ, and Zhu H: Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell, 2014, 26(2), 248-261.
  53. Kumar A, Lo S-T, Oz OK, and Sun X: Derivatization of (±) dihydrotetrabenazine for copper-​64 labeling towards long-​lived radiotracers for PET imaging of the vesicular monoamine transporter 2, Med. Chem. Lett., 2014, 24(24):5663-5665.
  54. Cai H, Singh AN, Sun X, and Peng F: Synthesis and Characterization of Her2-​NLP Peptide Conjugates Targeting Circulating Breast Cancer Cells: Cellular Uptake and Localization by Fluorescent Microscopic Imaging. Fluores. 2015, 25(1), 113-117.  
  55. Hao G, Liu W, Hassan G, Oz OK, Kovacs Z, and Sun X: A comparative study of trans- and cis-​isomers of a bone-​seeking agent, DO2A2P. Med. Chem. Lett., 201525(3), 571-574. 
  56. Yang S, Sun S, Zhou C, Hao G, Liu J, Ramezani S, Yu M, Sun X, and Zheng J: Renal Clearance and Degradation of Glutathione-​coated Copper Nanoparticles. Bioconjugate Chemistry, 2015, 26(3):511-519
  57. Kumar A, Zhang S, Hao G, Hassan G, Ramezani S, Lo S-T, Sagiyama K, Takahashi M, Sherry AD, Oz OK, Kovacs Z, and Sun X: Molecular Platform for Design and Synthesis of Targeted Dual-​modality Imaging Probes. Bioconjugate Chemistry, 2015, 26(3):549-558. ACS Editor’s Choice
  58. Kumar A, Hao G, Liu L, Ramezani S, Hsieh JT, Oz OK, and Sun X: Click-​Chemistry Strategy for Labeling Antibodies with Copper-​64 via a Cross-​Bridged Tetraazamacrocyclic Chelator Scaffold. Bioconjugate Chemistry, 2015, 26(4), 782-789.
  59. Huang C, Kearney V, Moeendarbari S, Jiang R, Christensen P, Tekade R, Sun X, Mao W, and Hao Y: Hollow gold nanoparticles as biocompatible radiosensitizer: an in vitro proof of concept study. Journal of Nano Research, 2015, 32, 106-112.
  60. Wu Y, Hao G, Ramezani S, Saha D, Zhao D, Sun X, and Sherry AD: [68Ga]-HP-DO3A-nitroimidazole: A Promising Agent for PET Detection of Tumor Hypoxia. Contrast Media and Molecular Imaging, 2015, in press.
  61. Pozo K, Hillmann A, Augustyn A, Plattner F, Hai T, Singh T, Ramezani S, Sun X, Pfragner R, Minna JD, Cote GJ, Chen H, Bibb JA, and Nwariaku FE: Differential expression of cell cycle regulators in CDK5- dependent medullary thyroid carcinoma tumorigenesis. Oncotarget, 2015, 6(14), 12080-12093
  62. Gerber DE, Hao G, Watkins L, Stafford JH, Anderson J, Holbein B, Öz OK, Mathews D, Thorpe PE, Hassan G, Kumar A, Brekken RA, and Sun X: Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts. J. Nucl. Med. Mol. Imaging, 2015, in press
  63. Pillai AK, Silvers W, Christensen P, Riegel M, Adams-Huet B, Lingvay I, Sun X, Oz OK: Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge. Diabetes Res., 2015 in press
  64. C-terminal variable AGES domain of Thymosin 4: the molecule's primary contribution in support of post-ischemic cardiac function and repair

Book Chapters and Invited Review Articles (since 2005)

  1. Lin X, Lubag A, McGuire MJ, Seliounine SY, Tsyganov EN, Antich PP, Sherry AD, Brown KC, and Sun X: Advances in molecular imaging of pancreatic beta cells. Frontiers in Bioscience, 2008, 13, 4558-4575.
  2. Chen W, and Sun X: Luminescent Nanoparticles for Biological Applications: Imaging, Therapy, and Targeting Strategies. Recent Advances of Bioconjugate Chemistry in Molecular Imaging. Chapter 20, p1-59; Publisher: Research Signpost; ISBN: 978-81-308-0210-7,
  3. Hao G, Singh A, Liu W, and Sun X: PET with Non-Standard Nuclides. Curr Top Med Chem. 2010, 10(11): 1096-1112. PMID: 20388114.
  4. Hao G, Singh A, Oz OK, and Sun X: Recent Advances in Copper Radiopharmaceuticals. Curr Radiopharm. 2011, 4, 109-121.
  5. Jin W, Hao G, Sun X and Chen W: Nanoparticle-based Nuclear Imaging of Cancer. Reviews in Nanosciences and Nanotechnology, 2012, 1, 3-21.
  6. Wu Y, Sun X, and Sherry AD: Molecular Imaging and Cancer Management: PET and MR Agents for Molecular Imaging of Cancer Metabolism. Chapter 20 of “Principles of Molecular Diagnostics and Personalized Cancer Medicine”. Edited by Dr. Tan and Dr. Lynch. Published by Wolters Kluwer Health--Lippincott Williams & Wilkins,
  7. Lo S-T, Kumar A, and Sun X: Delivery and Controlled Release of Therapeutics via Dendrimer Scaffolds. A book chapter of “Nanoparticle Delivery of Biotherapeutics” edited by Vooght-Johnson. Published by Future Science Group, 2014.