Research

Benign Prostatic Hyperplasia

Cross-section of prostate
Cross-section of a prostate gland, showing the transition zone (TZ) and the peripheral zone (PZ)

The goal of the Strand laboratory is to understand the cellular and molecular biology of benign prostatic hyperplasia (BPH). BPH is present in the vast majority of men over 70 years old, caused by the expansion of the zone of the prostate that surrounds the urethra.

We focus on translational questions related to progression of BPH in order to develop new targets for therapeutic intervention. In particular, we are interested in the nexus of metabolism, hormones, inflammation and stem cells as potential underlying causes of prostatic enlargement and fibrosis.

Because of the complex interplay of factors, the pathology of BPH is highly heterogeneous, suggesting that personalized therapies will be needed. Therefore, our goal is to characterize the molecular basis of varying phenotypes using a broad array of techniques on human and mouse tissues.