Research

Regulating Flagellar Assembly and Disassembly

Graph of Calk phosphorylation wtih time
Phosphorylation of the activation loop of the aurora-like protein kinase CALK is a molecular marker of flagellar length.

In collaborative studies with Junmin Pan, Ph.D., of Tsinghua University in Beijing, China, we are studying the roles of an aurora-like protein kinase, intraflagellar transport, and a depolymerizing kinesin in flagellar assembly, disassembly, and length control. We find that the extent of phosphorylation on the activation loop of the aurora-like protein kinase CALK is a molecular marker of flagellar length.

(Cao, M, Meng, D, Wang, L, Bei, S, *Snell, WJ and *Pan, J (*Co-corresponding authors) PNAS 2013.)