Selected Publications

Mary-Sinclair MN, Wang X, Swanson DJ, Sung CY, Mendonca EA, Wroblewski K, Baumer SH, Goldowitz D, Jablonski MM, Skapek SX. 2014. Varied manifestations of persistent hyperplastic primary vitreous with graded somatic mosaic deletion of a single gene. Mol Vis, 20: 215-230

Iqbal N, Mei J, Liu J, Skapek SX. 2014. miR-34a is essential for p19Arf-driven cell cycle arrest. Cell Cycle, 13: 792-800

Zheng Y, Devitt C, Liu J, Iqbal N, Skapek SX. 2013. Arf induction by Tgfβ is influenced by Sp1 and C/ebpβ in opposing directions. PLoS One, 8: e70371

Wilson RA, Teng L, Bachmeyer KM, Bissonnette ML, Husain AN, Parham DM, Triche TJ, Wing MR, Gastier-Foster JM, Barr FG, Hawkins DS, Anderson JR, Skapek SX, Volchenboum SL. 2013. A novel algorithm for simplification of complex gene classifiers in cancer. Cancer Res73:5625-32

Zheng Y, Devitt C, Liu J, Mei J, Skapek SX. 2013. A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye. Dev Biol, 380: 49-57

Widau RC, Zheng Y, Sung CY, Zelivianskaia A, Roach LE, Bachmeyer KM, Abramova T, Desgardin A, Rosner A, Cunningham JM, Skapek SX. 2012. p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanisms. Mol Cell Biol, 32: 4270-82

Saab R, Spunt SL, Skapek SX. 2011. Myogenesis and rhabdomyosarcoma the Jekyll and Hyde of skeletal muscle. Curr Top Dev Biol, 94: 197-234

Zheng Y, Zhao YD, Gibbons M, Abramova T, Chu PY, Ash JD, Cunningham JM, Skapek SX. 2010. Tgfbeta signaling directly induces Arf promoter remodeling by a mechanism involving Smads 2/3 and p38 MAPK. J Biol Chem, 285: 35654-64

Anderson-Freeman NE, Zheng Y, McCalla-Martin AC, Zheng Y, Treanor LM, Zhao YD, Garfin PM, He TC, Mary MN, Thornton JD, Anderson C, Gibbons M, Saab R, Baumer SH, Cunningham J, and Skapek SX. 2009. Expression of the Arf tumor suppressor gene is controlled by Tgfb2 during development. Development,
136: 2081-9

Saab R, Rodriguez-Galindo C, Matmati K, Rehg J, Baumer SH, Khoury JD, Billups C, Neale G, Helton KJ, Skapek SX. 2009. p18Ink4cand p53 act as tumor suppressors in Cyclin D1-driven primitive neuroectodermal tumor. Cancer Res, 9: 440-8

Thornton JD, Swanson DJ, Mary MN, Pei D, Martin AC, Pounds S, Goldowitz D, Skapek SX. 2007. Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor. Invest Ophthalmol Vis Sci, 48: 491-9

Skapek SX, Pan YR, Lee EY. 2006. Regulation of cell lineage specification by the retinoblastoma tumor suppressor. Oncogene, 25: 5268-76

Saab R, Bills JL, Miceli AP, Anderson CM, Khoury JD, Fry DW, Navid F, Houghton PJ, Skapek SX. 2006. Pharmacologic inhibition of cyclin-dependent kinase 4/6 activity arrests proliferation in myoblasts and rhabdomyosarcoma-derived cells. Mol Cancer Ther, 5: 1299-308

Thornton JD, Silva RL, Martin AC, Skapek SX. 2005. The Arf tumor suppressor regulates platelet-derived growth factor receptor beta signaling: a new view through the eyes of Arf(-/-) mice. Cell Cycle, 4: 1316-9

Silva RL, Martin AC, Thornton JD, Rehg JE, Berwistle D, Zindy F, and Skapek SX. 2005. Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing eye. EMBO J, 24: 2803-2814

Martin AC, Thornton JD, Liu J, Wang X, Zuo J, Jablonski MM, Chaum E, Zindy F, Skapek SX. 2004. Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene. Invest Ophthalmol Vis Sci, 45: 3387-96

McKeller RN, Fowler JL, Cunningham JJ, Warner NW, Smeyne RJ, Zindy F, and Skapek SX. 2002. The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development.  Proc Natl Acad Sci USA, 99: 3848-3853

Skapek SX, Lin SC, Jablonski MM, McKeller RN, Tan M, Hu N, Lee EY. 2001. Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development. Oncogene, 20: 6742-51

Skapek SX, Jansen D, Wei TF, McDermott T, Huang W, Olson EN, Lee EY. 2000. Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB. J Biol Chem, 275: 7212-23

Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB. 1996. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol Cell Biol, 16: 7043-53

Skapek SX, Rhee J, Spicer DB, Lassar AB. 1995. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science, 267: 1022-1024

See more of Dr. Skapek's publications on PubMed.