Our primary interests are in the molecular biology of cell surface molecules governing adhesion to and transmigration through vascular endothelium.

We have been engaged in the characterization, cloning, and functional attributes of adhesion molecules, including the lymph node homing receptor (LHR, L-selectin) in mouse and man, as well as the cartilage link family member CD44. 

One of our main goals is to study the role of adhesion receptors and their regulation in autoimmune and chronic inflammatory conditions.

Our more recent studies in both animal models and human autoimmune conditions have led us to explore the role of this adhesion pathway particularly in regulatory T cells, which are pivotal in controlling responses to infectious agents, to protecting tissues from autoimmune attacks, in allowing tolerance to bone marrow and organ transplantation, and for moderating responses to tumor antigens.