Research

Defining the roles of endocytic accessory proteins in CME

Using in vivo approaches, including siRNA knockdown, CRISPR knockout and rescue experiments coupled to quantitative total internal reflection fluorescence microscopy (TIR-FM) we are defining the function of EAPs and the hierarchy of molecular events that govern CCP maturation and CCV formation (Mettlen et al., MBoC, 2009; Antonescu et al., MBoC, 2011, Aguet et al., Dev. Cell, 2013). This work is funded by NIH grants MH61345 and GM73165.

EAP diagram