Research

Research

Cardiac Regeneration

Atmospheric oxygen induces cardiomyocyte cell cycle arrest in postnatal mouse heart.

We recently identified a brief window in early postnatal life during which the mammalian heart can undergo complete regeneration following various types of injury. This regenerative capacity is largely mediated through the proliferative competency of the pre-existing cardiomyocytes, and is lost by end of the first week of life.

This transient regenerative potential of the neonatal mouse heart provides a platform to study the molecular mechanisms that regulate mammalian heart regeneration. A major focus of our lab is to identify critical regulators of cardiomyocyte proliferation and cell cycle arrest in the neonatal heart, and discover new methods to reawaken cardiac regeneration in the adult mammalian heart.