Publications for Margaret Phillips, Ph.D.

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Featured Publications

GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.

Li Q, Leija C, Rijo-Ferreira F, Chen J, Cestari I, Stuart K, Tu BP, Phillips MA Mol. Microbiol. 2015 Jun

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors.

Deng X, Kokkonda S, El Mazouni F, White J, Burrows JN, Kaminsky W, Charman SA, Matthews D, Rathod PK, Phillips MA J. Med. Chem. 2014 May

Genetic validation of Aminoacyl tRNA synthetases as drug targets in Trypanosoma brucei.

Kalidas S, Cestari I, Monnerat S, Li Q, Regmi S, Hasle N, Labaied M, Parsons M, Stuart K, Phillips MA Eukaryotic Cell 2014 Feb

Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme.

Xiao Y, Nguyen S, Kim SH, Volkov OA, Tu BP, Phillips MA Mol. Microbiol. 2013 Jun 88 5 846-61

Trypanosoma brucei S-Adenosylmethionine Decarboxylase N Terminus Is Essential for Allosteric Activation by the Regulatory Subunit Prozyme.

Velez N, Brautigam CA, Phillips MA J. Biol. Chem. 2013 Feb 288 7 5232-40

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

Gujjar R, El Mazouni F, White KL, White J, Creason S, Shackleford DM, Deng X, Charman WN, Bathurst I, Burrows J, Floyd DM, Matthews D, Buckner FS, Charman SA, Phillips MA, Rathod PK J. Med. Chem. 2011 Jun 54 11 3935-49

Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes

Willert, E.K. and Phillips, M.A. PLoS pathogens October 2008 4 (10) e1000183

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