The Radiochemistry Laboratory is located on the 3rd floor of the Bill and Rita Clements Advanced Medical Imaging Building (NE building). The radiochemistry laboratory is equipped with cutting-edge equipment to provide capabilities for radiolabeling of a variety of molecules, ranging from small molecules to peptides, proteins and nanoparticles. The laboratory holds a GE TracerLab FXFN synthesis module for the automated radiolabeling of compounds, and two lead shielded hoods, for manual radiochemistry processing. A 68Ge/68Ga benchtop generator provides capabilities for the production of radiotracers labeled with 68Ga. The lab also contains a Waters HPLC and a GE FPLC for product purification and quality control. Other equipment includes: Raytest Radio-TLC, PerkinElmer phosphor imager, and an Agilent 7700X ICP-MS. A Brookhaven NanoBrook Omni particle analyzer and a DynaPro Titan microsampler from Wyatt Technology facilitate nanoparticle-based research.
Housed partly within both the Radiochemistry Research Laboratory and shared rooms in adjacent areas, our the cell-culture rooms are equipped with Nuaire Labgard biological safety hoods for working with both unlabeled and radiolabeled cells. The cell-culture facility has two nitrogen storage dewars with storage capability for 5,500 vials. The lab is equipped with a number of Thermo Scientific Forma Series II incubators, water baths, refrigerated and non-refrigerated centrifuges, microfuges and a Leica DMi1 microscope with an MC120 Camera. A number of upright and chest -80°C freezers, -20° C freezer, and conventional frost-free refrigerators are housed in the laboratory. The lab is also equipped with thermal cyclers for both conventional and real-time PCR, ovens and shakers for bacteria growth and culture, and gel apparatus for protein and nucleic acid gels.
The Preclinical Nuclear Research Laboratory is an UT Southwestern IACUC-approved satellite housing research laboratory capable of housing 14 cages of animals (≤ 56 Mice) for up to 72 hours at a time for imaging experiments. For animal surgery and biodistribution/pharmacological studies there is dedicated isolated space in the Radiochemistry Research Laboratory. The equipment available to researchers includes: Beckman Coulter LS 6500 Multi-Purpose Scintillation Counter, PerkinElmer 2480 Wizard 3” Automatic Gamma Counter and a Leica CM 1950 Cryostat.
Located on the 3rd floor of the Bill and Rita Clements Advanced Medical Imaging Building (NE building), the preclinical nuclear imaging laboratory is equipped with a state-of-the-art Siemens Inveon PET/CT Multimodality System for laboratory animal PET and CT studies on a single integrated gantry. The imaging lab is also equipped with a BioScan NanoSPECT/CT Plus. It is a dual-modality system for imaging mice and rats but can also image small rabbits. The system is capable of imaging a range of isotopes from the low-energy 125I to111In, alone or in triple isotope acquisition mode. It is capable of high-sensitivity submillimeter imaging, dynamic SPECT and gated cardiac SPECT imaging. An optional integrated animal-handling system is available that provides a pathogen-free imaging environment. The CT components of both systems can be used to produce high-quality, high resolution images of rodent organs including trabecular bone.