Research

Immunobiology of Uveal Melanoma

Immunobiology of Uveal Melanoma

Significance

Uveal Melanoma is the most common and malignant ocular tumor in adults. The 5-year survival time for uveal melanoma patients has not improved in over 30 years.

Ongoing Studies

  • What is the basis for increased liver metastases of intraocular melanomas in aged versus young mice?
  • What are the mechanisms invoked by NKT cells that disable NK cell-mediated cytolytic function in the liver and exacerbate metastasis of intraocular melanomas?
  • What role do tumor-associated neutrophils (TAN) play in the development of liver metastases arising from intraocular melanomas?

Animal Models and Research Tools 

  • NOD/SCID model of human uveal melanoma
  • Panel of 10 human uveal melanoma cell lines and 3 liver metastases cell lines including OCM-3-GFP human uveal melanoma cell line that expresses green fluorescent protein
  • siRNA for inhibiting CXCR4 chemokine receptor expression is used for “proof of principle” studies on the role of chemokine receptors in the formation of liver metastases